Zvinyorwa zvine hukama kumba nekune dzimwe nyika mukugadzirira kwemishonga excipients hydroxypropyl methylcellulose (HPMC) mumakore achangopfuura akaongororwa, akaongororwa uye akapfupikiswa, uye kushandiswa kwayo mukugadzirira kwakasimba, kugadzirira kwemvura, kutsigirwa uye kudzora kusunungurwa gadziriro, capsule kugadzirira, gelatin mashandisirwo mumunda wekuumbwa kutsva senge adhesive formulations uye bioadhesives. Nekuda kwekusiyana kwehuremu hwemamorekuru uye viscosity yeHPMC, ine maitiro uye mashandisiro emulsification, adhesion, thickening, viscosity kuwedzera, kumisa, gelling uye firimu-kugadzira. Inoshandiswa zvakanyanya mukugadzirira kwemishonga uye ichaita basa guru mumunda wekugadzirira. Nekunzvera kwakadzama kwezvivakwa zvayo uye kuvandudzwa kwehunyanzvi hwekugadzira, HPMC ichashandiswa zvakanyanya mukutsvagisa mafomu matsva emushonga uye masisitimu matsva ekupa zvinodhaka, nekudaro ichikurudzira kuenderera mberi kwekugadzirwa.
hydroxypropyl methylcellulose; kugadzirira kwemishonga; mishonga excipients.
Pharmaceutical excipients haisi iyo chete hwaro hwezvinhu zvekugadzira zvinodhaka zvinodhaka, asi zvakare zvine chekuita nekuoma kwegadziriro yekugadzirira, mhando yezvinodhaka, kugadzikana, kuchengetedzwa, chiyero chekuburitswa kwezvinodhaka, maitiro ekuita, kushanda kwekiriniki, uye kuvandudzwa kwezvitsva. mafomu emushonga uye nzira itsva dzekutonga. zvakabatana. Kubuda kwemishonga mitsva yemishonga inowanzokurudzira kuvandudzwa kwehutano hwekugadzirira uye kugadzirwa kwemafomu matsva emushonga. Hydroxypropyl methylcellulose (HPMC) ndechimwe chezvinhu zvinonyanya kufarirwa zvemishonga pamusha nekune dzimwe nyika. Nekuda kwehuremu hwayo hwakasiyana huremu uye viscosity, ine mabasa emulsifying, kusunga, kukora, kukora, kumisa, uye kunama. Zvimiro uye mashandisiro akaita senge coagulation uye kuumbwa kwemafirimu anoshandiswa zvakanyanya muhunyanzvi hwemishonga. Ichi chinyorwa chinonyanya kuongorora mashandisirwo ehydroxypropyl methylcellulose (HPMC) mukuumbwa mumakore achangopfuura.
1.Basic zvimiro zveHPMC
Hydroxypropyl methyl cellulose (HPMC), iyo molecular formula ndeye C8H15O8- (C10 H18O6) n- C8H15O8, uye hukama hwema molecular mass inenge 86 000. Ichi chigadzirwa i semi-synthetic material, iyo chikamu chemethyl uye chikamu che polyhydroxypropyl ether ye cellulose. Inogona kugadzirwa nenzira mbiri: Imwe ndeyekuti methyl cellulose yegiredhi yakakodzera inobatwa neNaOH uye yobva yaitwa nepropylene oxide pasi pekupisa kwakanyanya uye kudzvanywa kwakanyanya. Nguva yekuita inofanira kugara kwenguva yakareba zvakakwana kubvumira methyl uye hydroxypropyl kuti iite ether zvisungo Inobatanidzwa kune anhydroglucose ring ye cellulose nenzira ye cellulose, uye inogona kusvika kune dhigirii yaidiwa; imwe yacho ndeye kurapa donje linter kana huni pulp fiber ne caustic soda, uyezve kuita ne chlorinated methane uye propylene oxide zvakatevedzana, uye wozowedzera kunatsa. , yakapwanyika kuita upfu hwakatsetseka uye hwakafanana kana magranules.
Rudzi rwechigadzirwa ichi rwakachena kune mukaka chena, husina hwema uye husina kunaka, uye fomu iri granular kana fibrous nyore-kuyerera poda. Ichi chigadzirwa chinogona kunyungudutswa mumvura kuti iite yakajeka kune mukaka chena colloidal mhinduro ine imwe viscosity. Iyo sol-gel interconversion phenomenon inogona kuitika nekuda kwekushanduka kwekushisa kwemhinduro ine kumwe kusungwa.
Nekuda kwekusiyana kwezviri mukati mezviviri izvi zvinotsiva muchimiro chemethoxy uye hydroxypropyl, mhando dzakasiyana dzezvigadzirwa dzakaonekwa. Mukutarisisa chaiko, marudzi akasiyana ezvigadzirwa ane chaiwo maitiro. Viscosity uye thermal gelation tembiricha, saka zvine zvinhu zvakasiyana uye zvinogona kushandiswa kune zvakasiyana zvinangwa. Pharmacopoeia yenyika dzakasiyana-siyana ine mirau yakasiyana uye inomiririra pamuenzaniso: Iyo European Pharmacopoeia yakavakirwa pamagiredhi akasiyana eeviscosities akasiyana uye madhigirii akasiyana ekutsiviwa kwezvigadzirwa zvinotengeswa mumusika, zvinoratidzwa nemagiredhi pamwe nenhamba, uye chikamu chiri "mPa s. ”. MuUS Pharmacopoeia, manhamba e4 anowedzerwa mushure mezita rezita kuti aratidze zviri mukati uye rudzi rwechimwe nechimwe chinotsiva hydroxypropyl methylcellulose, senge hydroxypropyl methylcellulose 2208. Nhamba mbiri dzekutanga dzinomiririra kukosha kweiyo methoxy boka. Percentage, manhamba maviri ekupedzisira anomiririra inenge muzana yehydroxypropyl.
Calocan's hydroxypropyl methylcellulose ine 3 akatevedzana, anoti E akatevedzana, F akatevedzana uye K akateedzana, imwe neimwe nhevedzano ine akasiyana emhando yekusarudza kubva. E yakatevedzana inonyanya kushandiswa semafirimu ekuputira, anoshandiswa pakuputira piritsi, akavharwa piritsi cores; E, F akatevedzana anoshandiswa seviscosifiers uye kusunungura kudzoreredza maajenti ezve ophthalmic kugadzirira, kumisa maajenti, makobvu ekugadzirira mvura, mahwendefa uye Binders emagranules; K akateedzana anonyanya kushandiswa sekuburitsa inhibitors uye hydrophilic gel matrix zvinhu zvekunonoka uye zvinodzorwa kuburitsa gadziriro.
Vagadziri vemumba vanonyanya kusanganisira Fuzhou No. 2 Chemical Factory, Huzhou Food and Chemical Co., Ltd., Sichuan Luzhou Pharmaceutical Accessories Factory, Hubei Jinxian Chemical Factory No. ., Ltd., Xi'an Huian makemikari zvidyarwa, nezvimwe.
2.Zvakanakira zveHPMC
HPMC yave imwe yezvinonyanya kushandiswa mishonga excipients kumba uye kunze, nokuti HPMC ine zvakanakira izvo vamwe excipients havana.
2.1 Kunyungudika kwemvura inotonhora
Soluble mumvura inotonhora iri pasi pe40 ℃ kana 70% ethanol, isinganyungudike mumvura inopisa inopfuura 60 ℃, asi inogona gel.
2.2 Kemikari inert
HPMC imhando ye-non-ionic cellulose ether, mhinduro yayo haina ionic charge uye haibatanidzi nesimbi yemunyu kana ionic organic compounds, saka zvimwe zvinobatsira hazviiti nazvo panguva yekugadzirwa kwegadziriro.
2.3 Kugadzikana
Yakagadzikana kune ese aridhi uye alkali, uye inogona kuchengetwa kwenguva yakareba pakati pepH 3 ne11 pasina shanduko yakakosha muviscosity. Iyo aqueous solution yeHPMC ine anti-mildew effect uye inochengetedza yakanaka viscosity kugadzikana panguva yekuchengetedza kwenguva refu. Mishonga yemishonga inoshandisa HPMC ine kugadzikana kwemhando iri nani pane iyo inoshandisa zvechinyakare excipients (senge dextrin, starch, nezvimwewo).
2.4 Viscosity Adjustability
Different viscosity derivatives yeHPMC inogona kusanganiswa muzvikamu zvakasiyana, uye viscosity yayo inogona kuchinjwa maererano nemumwe mutemo, uye ine hukama hwakanaka hwemutsara, saka chikamu chinogona kusarudzwa maererano nezvinodiwa.
2.5 Metabolic inertness
HPMC haina kunyudzwa kana kugadzirwa mumuviri, uye haipi kupisa, saka yakachengeteka mishonga yekugadzirira excipient. 2.6 Kuchengetedzwa Kunowanzoonekwa kuti HPMC chinhu chisina chepfu uye chisingaiti, chiyero chepakati chinouraya chembeva ndeye 5 g · kg - 1, uye chirwere chepakati chinouraya makonzo ndeye 5. 2 g · kg - 1. Chiyero chezuva nezuva hachina ngozi kumuviri wemunhu.
3.Kushandiswa kweHPMC mukuumbwa
3.1 Sezvinhu zvekuputira firimu uye firimu-kugadzira zvinhu
Uchishandisa HPMC senge firimu-yakavharwa piritsi rezvinhu, piritsi rakaputirwa harina zvakanakira kuvharidzira kuravira uye chitarisiko kana zvichienzaniswa neyakajairwa mahwendefa akadai semapiritsi akaputirwa neshuga, asi kuoma kwayo, kunyungudika, kunyura, dhigirii rekuparara. , kuvhara kuwedzera kuwedzera uye zvimwe zviratidzo zvehutano zviri nani. Iyo yakaderera-viscosity giredhi yechigadzirwa ichi inoshandiswa semvura-inonyungudika firimu yekuputira zvinhu zvemapiritsi nemapiritsi, uye iyo yepamusoro-viscosity giredhi inoshandiswa seyefirimu yekuputira zvinhu zveorganic solvent masisitimu, kazhinji pachikamu che2% kusvika makumi maviri. %.
Zhang Jixing et al. yakashandisa maitiro epamusoro nzira kukwidziridza iyo premix kuumbwa neHPMC seyekuputira firimu. Kutora iyo firimu-inogadzira zvinhu HPMC, huwandu hwepolyvinyl doro uye plasticizer polyethylene glycol sezvinhu zvekuferefeta, kusimba kwesimba uye kupera kwefirimu uye The viscosity yefirimu yekuputira mhinduro indekisi yekuongorora, uye hukama pakati pekuongorora. indekisi uye zvinhu zvekuongorora zvinotsanangurwa nemuenzaniso wemasvomhu, uye iyo yakakwana yekugadzira nzira inozowanikwa. Kushandiswa kwayo kwakateerana firimu-inogadzira agent hydroxypropyl methylcellulose (HPMCE5) 11.88 g, polyvinyl doro 24.12 g, plasticizer polyethylene glycol 13.00 g, uye coating suspension viscosity ndeye 20 mPa·s, iyo permeability uye kusimba kwakasimba kwemufirimu kwakasvika pakusimba kwesimba. . Zhang Yuan akavandudza maitiro ekugadzirira, akashandisa HPMC sebhainda kutsiva starch slurry, uye akachinja mahwendefa eJiahua kuva mahwendefa akavharidzirwa nefirimu kuti avandudze kunaka kwekugadzirira kwayo, kuvandudza hygroscopicity yayo, nyore kupera, mahwendefa asina kusimba, akatsemuka uye mamwe matambudziko, kuwedzera kugadzikana kwehwendefa. Iyo yakakwana yekugadzira maitiro yakatemerwa ne orthogonal kuyedza, iyo, iyo slurry concentration yaive 2% HPMC mu 70% ethanol mhinduro panguva yekupfeka, uye nguva yekukurudzira panguva yegranulation yaive 15 min. Mhedzisiro Mahwendefa eJiahua akavharidzirwa nefirimu akagadzirwa nemaitiro matsva uye kunyorerwa akavandudzwa zvakanyanya pakuonekwa, nguva yekuparara uye kuomarara kwepakati pane izvo zvakaburitswa nemaitiro ekutanga emishonga, uye mwero wakakodzera wemapiritsi akavharwa nefirimu akavandudzwa zvakanyanya. yakasvika kupfuura 95%. Liang Meiyi, Lu Xiaohui, nezvimwewo vakashandisawo hydroxypropyl methylcellulose sechinhu chekugadzira firimu kugadzirira patinae colon positioning tablet uye matrine colon positioning tablet, zvichiteerana. kukanganisa kusunungurwa kwezvinodhaka. Huang Yunran akagadzirira Dragon's Ropa Colon Positioning Mahwendefa, uye akaisa HPMC kune yekubikira mhinduro yekuzvimba layer, uye chikamu chayo chikuru chaive 5%. Zvinogona kuonekwa kuti HPMC inogona kushandiswa zvakanyanya mucolon-yakanangana nemishonga yekuendesa zvinodhaka.
Hydroxypropyl methylcellulose haingori yakanakisa yekuputira firimu zvinhu, asi zvakare inogona kushandiswa senge firimu-inogadzira zvinhu mukugadzira firimu. Wang Tongshun nezvimwe zvakagadziridzwa kusvika pakunyorerwa kwecompound zinc licorice uye aminolexanol oral composite firimu, nekuchinjika, kufanana, kutsvedzereka, kubuda pachena kwemumiriri wemufirimu seindex index, kuwana dhizaini yakakwana iPVA 6.5 g, HPMC 0.1 g uye 6.0 g ye propylene glycol inosangana nezvinodiwa zvekunonoka-kusunungurwa uye kuchengeteka, uye inogona kushandiswa sekugadzirira kunyorerwa kweiyo composite firimu.
3.2 sebhainda uye disintegrant
Iyo yakaderera viscosity giredhi yechigadzirwa ichi inogona kushandiswa sebhainda uye disintegrant yemapiritsi, mapiritsi uye granules, uye yakakwirira viscosity giredhi inogona kungoshandiswa sebhainda. Chiyero chinosiyana nemhando dzakasiyana uye zvinodiwa. Kazhinji, dosage yebinder yemapiritsi egranulation yakaoma i5%, uye dosage yebinder yemapiritsi ekunyorova i2%.
Li Houtao et al vakaongorora binder yemapiritsi etinidazole. 8% polyvinylpyrrolidone (PVP-K30), 40% sirasi, 10% starch slurry, 2.0% hydroxypropyl methylcellulose K4 (HPMCK4M), 50% ethanol yakaongororwa sekubatanidzwa kwepiritsi tinidazole zvakare. kugadzirira mapiritsi tinidazole. Chitarisiko chinoshanduka chemapiritsi akajeka uye mushure mekuputira zvakaenzaniswa, uye friability, kuomarara, kupatsanurwa nguva yakatarwa uye kuparara mwero weakasiyana mahwendefa emishonga akayerwa. Mhedzisiro Mahwendefa akagadzirwa ne2.0% hydroxypropyl methylcellulose aive akapenya, uye kuyerwa kwefriability hakuna kuwana edge chipping uye cornering phenomenon, uye mushure mekuputira, chimiro chepiritsi chaive chakazara uye kutaridzika kwaive kwakanaka. Naizvozvo, mahwendefa etinidazole akagadzirwa ne2.0% HPMC-K4 uye 50% ethanol semabinder akashandiswa. Guan Shihai akadzidza magadzirirwo eFuganning Tablets, akaongorora zvinonamirwa, uye akaongorora 50% ethanol, 15% starch paste, 10% PVP uye 50% ethanol mhinduro ine compressibility, kutsetseka, uye friability sezviratidzo zvekuongorora. , 5% CMC-Na uye 15% HPMC mhinduro (5 mPa s). Mhedzisiro Mashizha akagadzirwa ne50% ethanol, 15% starch paste, 10% PVP 50% ethanol solution uye 5% CMC-Na yakanga ine nzvimbo yakatsetseka, asi isina kusimba uye yakaderera kuoma, iyo yaisakwanisa kuzadzisa zvinodiwa zvekupfeka; 15% HPMC mhinduro ( 5 mPa · s), pamusoro pepiritsi yakanyorova, iyo friability inokodzera, uye iyo compressibility yakanaka, inogona kusangana nezvinodiwa zvekupfeka. Naizvozvo, HPMC (5 mPa s) yakasarudzwa seyakanamatira.
3.3 semumiriri wekumisa basa
Iyo yakakwira-viscosity giredhi yechigadzirwa ichi inoshandiswa seanomisa mumiriri kugadzirira kumira-mhando yegadziriro yemvura. Iyo ine yakanaka kumisa mhedzisiro, iri nyore kuparadzirazve, haina kunamatira kumadziro, uye ine yakanaka flocculation particles. Iyo yakajairika dosage ndeye 0.5% kusvika 1.5%. Song Tian et al. inoshandiswa zvinowanzoshandiswa zvepolymer zvinhu (hydroxypropyl methylcellulose, sodium carboxymethylcellulose, povidone, xanthan gum, methylcellulose, nezvimwewo) semiti inomisa kugadzirira racecadotril. kumiswa kwakaoma. Kuburikidza neiyo sedimentation vhoriyamu reshiyo yekumisikidzwa kwakasiyana, iyo redispersibility index, uye rheology, suspension viscosity uye microscopic morphology zvakaonekwa, uye kugadzikana kwezvikamu zvezvinodhaka pasi pekuyedza kwakakurumidza kwakaongororwawo. Mhedzisiro Kumiswa kwakaoma kwakagadzirwa ne2% HPMC sezvo mumiriri wekumisa aive nemaitiro akareruka uye kugadzikana kwakanaka.
Kana ichienzaniswa nemethyl cellulose, hydroxypropyl methyl cellulose ine hunhu hwekugadzira mhinduro yakajeka, uye ishoma shoma yezvinhu zvisina kuparadzirwa fibrous zvinhu zviripo, saka HPMC inowanzoshandiswa seanomisa mumiriri mukugadzirira kwemaziso. Liu Jie et al. yakashandisa HPMC, hydroxypropyl cellulose (HPC), carbomer 940, polyethylene glycol (PEG), sodium hyaluronate (HA) uye musanganiswa weHA/HPMC seanomisa maajenti kugadzirira akasiyana zvirevo ZveCiclovir ophthalmic suspension, sedimentation volume ratio, particle size uye redispersibility. vanosarudzwa sezviratidzo zvekuongorora kuti vaone yakanakisa yekumisa mumiriri. Zvigumisiro zvinoratidza kuti acyclovir ophthalmic suspension yakagadzirwa ne 0.05% HA uye 0.05% HPMC seyo suspending agent, sedimentation volume ratio ndeye 0.998, chiyero chechikamu chakafanana, redispersibility yakanaka, uye kugadzirira kwakagadzikana Bonde rinowedzera.
3.4 Sevhavha, inononoka uye inodzorwa kuburitsa mumiririri uye pore-inogadzira agent
I-high-viscosity giredhi yechigadzirwa ichi inoshandiswa pakugadzirisa hydrophilic gel matrix yakasimbiswa-kusunungurwa mapiritsi, blockers uye inodzorwa-kusunungurwa maajenti e-mixed-material matrix akatsigira-kusunungurwa mapiritsi, uye ane mhedzisiro yekunonoka kusunungurwa kwezvinodhaka. Kuiswa kwayo kuri 10% kusvika 80%. Low-viscosity mamakisi anoshandiswa seporogens ekuchengetedza-kuburitswa kana kudzorwa-kuburitswa gadziriro. Chiyero chekutanga chinodiwa pakurapa kwemapiritsi akadaro anogona kukurumidza kusvika, uye ipapo iyo inoenderera-kuburitswa kana kudzorwa-kuburitswa mhedzisiro inoitwa, uye inoshanda yeropa zvinodhaka zvinodhaka zvinochengetwa mumuviri. . Hydroxypropyl methylcellulose inonatswa kuumba gel layer kana yasangana nemvura. Iyo nzira yekusunungurwa kwezvinodhaka kubva pahwendefa rematrix inonyanya kusanganisira kupararira kwejel layer uye kuputika kwejeri. Jung Bo Shim et al vakagadzirira mahwendefa e-carvedilol akasimudzira-kuburitswa neHPMC sechinhu chakasimba-chiburitswa.
Hydroxypropyl methylcellulose inoshandiswawo zvakanyanya mumapiritsi anoramba achiburitswa emushonga wechiChinese, uye mazhinji ezvigadzirwa zvinoshanda, zvikamu zvinoshanda uye gadziriro imwechete yemishonga yechinyakare yeChinese inoshandiswa. Liu Wen et al. yakashandisa 15% hydroxypropyl methylcellulose sematrix zvinhu, 1% lactose uye 5% microcrystalline cellulose semafirita, uye yakagadzirira Jingfang Taohe Chengqi Decoction mumuromo matrix mahwendefa anoburitswa. Muenzaniso ndiyo Higuchi equation. Iyo formula yekugadzira sisitimu iri nyore, kugadzirira kuri nyore, uye iyo yekuburitsa data yakagadzikana, iyo inosangana nezvinodiwa zveChinese Pharmacopoeia. Tang Guanguang et al. akashandisa saponins yakazara yeAstragalus semushonga wemuenzaniso, akagadzira mahwendefa eHPMC matrix, uye akaongorora zvinhu zvinokanganisa kuburitswa kwemushonga kubva munzvimbo dzinoshanda dzemushonga wechiChinese muHPMC matrix mapiritsi. Mhedzisiro Sezvo dosi yeHPMC yakawedzera, kuburitswa kweastragaloside kwakadzikira, uye chikamu chekuburitswa chemushonga chaive nehukama hunenge hwemutsara nehuwandu hwekuparara kwematrix. Mune hypromellose HPMC matrix piritsi, pane humwe hukama pakati pekuburitswa kwechikamu chinoshanda chemushonga wechinyakare weChinese uye dosi uye rudzi rweHPMC, uye kuburitswa kweiyo hydrophilic chemical monomer yakafanana nayo. Hydroxypropyl methylcellulose haisi yakakodzera chete kune hydrophilic compounds, asiwo kune isiri-hydrophilic zvinhu. Liu Guihua akashandisa 17% hydroxypropyl methylcellulose (HPMCK15M) seyakagadziriswa-yakaburitswa matrix zvinhu, uye akagadzirira Tianshan Xuelian akasimudzira-kuburitsa matrix mapiritsi nekunyorova granulation uye tableting nzira. Mhedzisiro yekusunungurwa-yakaramba iri pachena, uye nzira yekugadzirira yakanga yakagadzikana uye ichigoneka.
Hydroxypropyl methylcellulose haingoshandiswi chete kune akaenderera-kuburitswa matrix mahwendefa ezvishandiso zvinoshanda uye zvikamu zvinoshanda zvechinyakare Chinese mushonga, asiwo zvakanyanya uye zvakanyanya kushandiswa mumagariro echiChinese mushonga kugadzirira musanganiswa. Wu Huichao et al. yakashandisa 20% hydroxypropyl methyl cellulose (HPMCK4M) sematrix zvinhu, uye yakashandisa poda yakananga compression nzira yekugadzirira Yizhi hydrophilic gel matrix tablet iyo inogona kusunungura mushonga wacho nguva dzose uye yakasimba kwemaawa gumi nemaviri. Saponin Rg1, ginsenoside Rb1 uye Panax notoginseng saponin R1 dzakashandiswa sezviratidzo zvekuongorora kuongorora kuburitswa mu vitro, uye equation yekuburitsa zvinodhaka yakaiswa kuti idzidze nzira yekuburitsa zvinodhaka. Mhedzisiro Iyo nzira yekuburitsa mushonga inowirirana ne zero-order kinetic equation uye Ritger-Peppas equation, umo geniposide yakaburitswa neasiri-Fick diffusion, uye zvikamu zvitatu muPanax notoginseng zvakaburitswa nekukukurwa kweskeletal.
3.5 Inodzivirira guruu seyakakora uye colloid
Kana chigadzirwa ichi chikashandiswa seyakakora, iyo yakajairwa muzana yehuwandu ndeye 0.45% kusvika 1.0%. Iyo inogona zvakare kuwedzera kugadzikana kweiyo hydrophobic glue, kuumba inodzivirira colloid, kudzivirira zvimedu kubva pakubatana uye agglomerating, nokudaro zvichitadzisa kuumbwa kwesediments. Yayo yakajairika muzana yepakati ndeye 0.5% kusvika 1.5%.
Wang Zhen et al. yakashandisa iyo L9 orthogonal yekuedza dhizaini nzira yekuongorora maitiro ekugadzirira emushonga activated kabhoni enema. Mamiriro ezvinhu akanakisa ekugadzirisa kwekupedzisira kwemushonga activated kabhoni enema ndeye kushandisa 0.5% sodium carboxymethyl cellulose uye 2.0% hydroxypropyl methylcellulose (HPMC ine 23.0% methoxyl boka, hydroxypropoxyl Base 11.6%) seyakakora, maitiro anobatsira kuwedzera. kugadzikana kwemishonga activated carbon. Zhang Zhiqiang et al. yakagadzira pH-sensitive levofloxacin hydrochloride ophthalmic yakagadzirira-kushandisa gel ine inoenderera-kuburitsa mhedzisiro, ichishandisa carbopol seiyo gel matrix uye hydroxypropyl methylcellulose seyakakora mumiriri. Mushonga wakakwana nekuedza, pakupedzisira wawana optimal prescription is levofloxacin hydrochloride 0.1 g, carbopol (9400) 3 g, hydroxypropyl methylcellulose (E50 LV) 20 g, disodium hydrogen 0.35 g, phosphoric acid 0.45 g0 yesodium chlori 0,5 g ye sodium diphosphate. , 0.03 g ye ethyl paraben, uye mvura yakawedzerwa kuita 100 mL. Muyedzo, munyori akaongorora iyo hydroxypropyl methylcellulose METHOCEL yakatevedzana yeColorcon Kambani ine akasiyana zvirevo (K4M, E4M, E15 LV, E50LV) kugadzirira thickeners ane akasiyana mazinga, uye mhedzisiro yakasarudza HPMC E50 LV seyakakora. Thickener ye pH-sensitive levofloxacin hydrochloride instant gels.
3.6 se capsule zvinhu
Kazhinji, iyo capsule shell zvinhu zve capsules inonyanya gelatin. Iyo nzira yekugadzira iyo capsule shell iri nyore, asi kune mamwe matambudziko uye zviitiko zvakadai sekudzivirira kwakashata kubva kune hunyoro uye oxygen-sensitive zvinodhaka, kuderedzwa kuparara kwezvinodhaka, uye kunonoka kuparara kwekapule shell panguva yekuchengetedza. Naizvozvo, hydroxypropyl methylcellulose inoshandiswa sechinotsiva gelatin capsules yekugadzirira macapsules, iyo inovandudza iyo capsule yekugadzira formability uye mashandisiro ekushandisa, uye yakasimudzirwa zvakanyanya kumba nekune dzimwe nyika.
Kushandisa theophylline semushonga unodzora, Podczeck et al. akawana kuti chiyero chekuparara kwemishonga ye capsules ne hydroxypropyl methylcellulose shells yakanga yakakura kudarika iyo yegelatin capsules. Chikonzero chekuongorora ndechekuti kupatsanurwa kweHPMC ndiko kuparara kweiyo capsule yese panguva imwe chete, nepo kuparara kwegelatin capsule ndiko kuparara kweiyo network maitiro kutanga, uyezve kuparara kweiyo capsule yese, saka iyo HPMC capsule inonyanya kuenderana neCapsule shells yekukurumidza kuburitswa maumbirwo. Chiwele et al. akawanawo mhedziso dzakafanana uye akaenzanisa kupera kwegelatin, gelatin / polyethylene glycol uye HPMC shells. Zvigumisiro zvakaratidza kuti HPMC shells yakakurumidza kunyungudutswa pasi pemamiriro akasiyana epH, nepo gelatin capsules Inobatwa zvakanyanya nemamiriro akasiyana epH. Tang Yue et al. akaongorora rudzi rutsva rwecapsule shell yepasi-dose mushonga usina blank poda inhaler carrier system. Kuenzaniswa ne capsule shell ye hydroxypropyl methylcellulose uye capsule shell yegelatin, kugadzikana kwekapule shell uye zvinhu zvehupfu muhombodo pasi pemamiriro akasiyana-siyana zvakaongororwa, uye muedzo wefriability wakaitwa. Zvigumisiro zvinoratidza kuti kana zvichienzaniswa negelatin capsules, HPMC capsule shells zviri nani mukugadzikana uye kuchengetedzwa kwehupfu, ane simba rekudzivirira mwando, uye ane friability yakaderera kupfuura gelatin capsule shells, saka HPMC capsule shells inonyanya kukodzera ma Capsules for dry powder inhalation.
3.7 se bioadhesive
Bioadhesion tekinoroji inoshandisa excipients ine bioadhesive polymers. Nekunamatira kune biological mucosa, inowedzera kuenderera uye kusimba kwekubatana pakati pekugadzirira uye mucosa, kuitira kuti mushonga wacho usunungurwe zvishoma nezvishoma uye unobatwa nemucosa kuti uwane chinangwa chekurapa. Inoshandiswa zvakanyanya pari zvino. Kurapa kwezvirwere zvegastrointestinal turakiti, vagina, oral mucosa uye zvimwe zvikamu.
Gastrointestinal bioadhesion tekinoroji inzira nyowani yekuunza zvinodhaka yakagadziriswa mumakore achangopfuura. Izvo hazvisi kungowedzera nguva yekugara yekugadzirira zvinodhaka mudumbu remukati, asi zvakare inovandudza kusangana kwekuita pakati pemushonga uye sero membrane panzvimbo yekunyura, inoshandura kuyerera kwesero membrane, uye inoita Kupinda kwemushonga kupinda. masero maduku epithelial epithelial anowedzerwa, nokudaro achivandudza bioavailability yemushonga. Wei Keda et al. akaongorora mushonga wepiritsi core nedosage yeHPMCK4M neCarbomer 940 sezvikonzero zvekuferefeta, uye akashandisa mudziyo wakazvigadzira wega bioadhesion kuyera simba rekusvuura pakati pepiritsi uye yakatevedzerwa biofilm nemhando yemvura iri mubhegi repurasitiki. , uye pakupedzisira akasarudza zvinyorwa zveHPMCK40 uye carbomer 940 kuti ive 15 uye 27.5 mg munzvimbo yakanyatsogadziriswa yeNCaEBT tablet cores, maererano, kugadzirira NCaEBT tablet cores, zvichiratidza kuti bioadhesive zvinhu (zvakadai sehydroxypropyl methylcellulose) inogona kuderedza zvakanyanya Kuvandudza kunamatira kwekugadzirira kune tishu.
Oral bioadhesive kugadzirira zvakare rudzi rutsva rwekuunza zvinodhaka sisitimu yakadzidzwa zvakanyanya mumakore achangopfuura. Oral bioadhesive gadziriro inogona kunamatira mushonga kune yakakanganiswa chikamu chemumuromo mhango, iyo isingarebe chete nguva yekugara yemushonga mumuromo mucosa, asiwo inodzivirira mucosa yemuromo. Zvirinani kurapa maitiro uye kuvandudzwa kwezvinodhaka bioavailability. Xue Xiaoyan et al. yakagadziridza kugadzirwa kwe insulin oral adhesive tablets, uchishandisa apple pectin, chitosan, carbomer 934P, hydroxypropyl methylcellulose (HPMC K392) uye sodium alginate sezvinhu zvinonamatira bioadhesive, uye kuomesa-kuomesa kugadzirira oral insulin. Adhesive double layer sheet. Iyo yakagadzirirwa insulin oral adhesive piritsi ine porous sponge-yakafanana chimiro, iyo yakanakira insulin kuburitswa, uye ine hydrophobic inodzivirira layer, iyo inogona kuve nechokwadi chekuburitswa kwemushonga uye kudzivirira kurasikirwa kwemushonga. Hao Jifu et al. akagadzirawo mabheji eblue-yero oral bioadhesive patches achishandisa Baiji glue, HPMC uye carbomer sezvinhu zvinonamatira bioadhesive.
Mumasystem ekuburitsa zvinodhaka, bioadhesion tekinoroji yakashandiswawo zvakanyanya. Zhu Yuting et al. yakashandisa carbomer (CP) uye HPMC sezvinhu zvinonamira uye inosimudzira-kuburitswa matrix kugadzirira clotrimazole bioadhesive vaginal mahwendefa ane akasiyana magadzirirwo uye reshiyo, uye akayera kunamatira kwavo, nguva yekunamatira uye kuzvimba muzana munzvimbo yeartificial vaginal fluid. , mushonga wakakodzera wakaongororwa seCP-HPMC1: 1, pepa rekunamatira rakagadzirirwa raive nekuita kwakanaka kwekunamatira, uye maitiro acho aive nyore uye aikwanisika.
3.8 setopical gel
Segadziriro yekunamatira, gel ine nhevedzano yezvakanakira sekuchengetedza, runako, nyore kuchenesa, mutengo wakaderera, nyore kugadzirira maitiro, uye kuenderana kwakanaka nemishonga. Nhungamiro yebudiriro. Semuyenzaniso, transdermal gel ndiyo itsva dosage fomu yakadzidzwa zvakanyanya mumakore achangopfuura. Haikwanise chete kudzivirira kuparadzwa kwezvinodhaka mudumbu uye kuderedza peak-to-trough kusiyana kweropa remushonga wezvinodhaka, asi zvakare yave imwe yeanobudirira dhizaini yekuburitsa masisitimu ekukunda zvinodhaka mhedzisiro. .
Zhu Jingjie et al. akadzidza mhedzisiro yematrices akasiyana pakuburitswa kwe scutellarin alcohol plastid gel in vitro, uye akaongororwa necarbomer (980NF) uye hydroxypropyl methylcellulose (HPMCK15M) segel matrices, uye akawana scutellarin yakakodzera scutellarin. Gel matrix yedoro plastids. Migumisiro yekuedza inoratidza kuti 1. 0% carbomer, 1. 5% carbomer, 1. 0% carbomer + 1. 0% HPMC, 1. 5% carbomer + 1. 0% HPMC se gel matrix Zvose zvakakodzera scutellarin alcohol plastids . Munguva yekuyedza, zvakaonekwa kuti HPMC yaigona kushandura nzira yekuburitsa zvinodhaka yecarbomer gel matrix nekukodzera kinetic equation yekuburitswa kwezvinodhaka, uye 1.0% HPMC inogona kuvandudza 1.0% carbomer matrix uye 1.5% carbomer matrix. Chikonzero chinogona kunge chiri chekuti HPMC inokura nekukurumidza, uye kukurumidza kuwedzera muchikamu chekutanga chekuyedza kunoita kuti gap rema molecular yecarbomer gel zvinhu zvikure, nekudaro ichimhanyisa mwero wayo wekuburitsa zvinodhaka. Zhao Wencui et al. yakashandisa carbomer-934 uye hydroxypropyl methylcellulose sevatakuri kugadzirira norfloxacin ophthalmic gel. Nzira yekugadzirira iri nyore uye inogoneka, uye hutano hunopindirana neophthalmic gel ye "Chinese Pharmacopoeia" (2010 edition) Zvinodiwa zvehutano.
3.9 Precipitation inhibitor ye self-microemulsifying system
Self-microemulsifying drug delivery system (SMEDDS) rudzi rutsva rweoral drug delivery system, iri homogeneous, yakagadzikana uye yakajeka musanganiswa inoumbwa nemishonga, chikamu chemafuta, emulsifier uye co-emulsifier. Kuumbwa kwechinyorwa chiri nyore, uye kuchengeteka uye kugadzikana kwakanaka. Kune zvinodhaka zvisinganyanyi kunyungudika, mvura-soluble fiber polymer zvinhu, senge HPMC, polyvinylpyrrolidone (PVP), zvichingodaro, zvinowanzowedzerwa kuti mishonga yemahara uye mishonga yakavharirwa mu microemulsion iwane kuparara kwakanyanya mudumbu remukati, kuitira kuti kuwedzera kunyungudika kwezvinodhaka uye kuvandudza bioavailability.
Peng Xuan et al. vakagadzira silibinin supersaturated self-emulsifying drug delivery system (S-SEDDS). Oxyethylene hydrogenated castor oil (Cremophor RH40), 12% caprylic capric acid polyethylene glycol glyceride (Labrasol) se-co-emulsifier, uye 50 mg·g-1 HPMC. Kuwedzera HPMC kuSSEDDS kunogona supersaturate yemahara silibinin kunyungudika muS-SEDDS uye kudzivirira silibinin kubva kunaya kunze. Kuenzaniswa neyakajairwa self-microemulsion formulations, yakakura yakawanda yesurfactant inowanzowedzerwa kudzivirira isina kukwana zvinodhaka encapsulation. Kuwedzerwa kweHPMC kunogona kuchengetedza kunyungudika kwesilibinin mumhepo yekunyunguduka kusingachinji, kuderedza emulsification mune self-microemulsion formulations. chipimo chemumiririri.
4. Mhedziso
Zvinogona kuonekwa kuti HPMC yakashandiswa zvakanyanya mukugadzirira nekuda kwemuviri wayo, makemikari uye zvipenyu, asi HPMC inewo zvikanganiso zvakawanda mukugadzirira, zvakadai sechiitiko chekusunungurwa kwekare uye mushure mekuputika. methyl methacrylate) kuvandudza. Panguva imwecheteyo, vamwe vaongorori vakaongorora mashandisirwo eiyo osmotic theory muHPMC nekugadzirira mahwendefa e-carbamazepine anoramba achiburitswa uye mahwendefa everapamil hydrochloride anoramba achiburitswa kuti aenderere mberi nekudzidza nzira yekuburitsa. Mushoko, vaongorori vakawanda vari kuita basa rakawanda rekushandiswa kuri nani kweHPMC mukugadzirira, uye nekudzidza kwakadzama kwezvivakwa zvayo uye kuvandudzwa kwehunyanzvi hwekugadzirira, HPMC ichashandiswa zvakanyanya mumhando nyowani dzedosi. uye mafomu matsva ekuyedza. Mukutsvaga kwemishonga system, uyezve kukurudzira kuenderera mberi kwekusimudzira kwemishonga.
Nguva yekutumira: Oct-08-2022