Hydroxypropyl methylcellulose (HPMC) is a synthetic semi-synthetic polymer inoshandiswa zvakanyanya mumaindasitiri mazhinji, kunyanya mumunda wemishonga. HPMC yave chinhu chinodiwa mukugadzirira kwemishonga nekuda kweiyo biocompatibility, isiri-chepfu uye yakanakisa yemuviri nemakemikari zvimiro.
(1) Hunhu hwakakosha hwegiredhi remishonga HPMC
HPMC isiri-ionic cellulose ether yakagadzirirwa nekuita kweselulosi nepropylene oxide uye methyl chloride pasi pemamiriro ealkaline. Yayo yakasarudzika kemikari chimiro inopa HPMC yakanakisa solubility, thickening, film-forming uye emulsifying zvivakwa. Aya anotevera mamwe akakosha maitiro eHPMC:
Kunyungudika kwemvura uye kutsamira kwepH: HPMC inonyungudika mumvura inotonhora uye inoumba yakajeka viscous mhinduro. Iyo viscosity yemhinduro yayo ine hukama nekutarisa uye kurema kwemamorekuru, uye ine kugadzikana kwakasimba kune pH uye inogona kuramba yakagadzikana mune ese aridhi uye alkaline nharaunda.
Thermogel zvivakwa: HPMC inoratidza yakasarudzika thermogel zvivakwa kana yapiswa. Inogona kugadzira gel kana ichipisa kune imwe tembiricha uye inodzokera kune yemvura mamiriro mushure mekutonhora. Iyi pfuma inonyanya kukosha mukugadzirira kusunungurwa kwezvinodhaka.
Biocompatibility uye isiri-chepfu: Sezvo HPMC iri kubva kune cellulose uye isina mubhadharo uye isingaite nezvimwe zvinongedzo, ine yakanakisa biocompatibility uye haizonyurirwe mumuviri. Iyo isiri-chepfu excipient.
(2) Kushandiswa kweHPMC mumishonga
HPMC inoshandiswa zvakanyanya muindasitiri yemishonga, ichivhara nzvimbo dzakawanda dzakadai semumuromo, wepamusoro uye mishonga inobaiwa. Maitiro ayo makuru ekushandisa ndeaya anotevera:
1. Mafirimu-kugadzira zvinhu mumapiritsi
HPMC inoshandiswa zvakanyanya mukuputira mahwendefa sechinhu chekugadzira firimu. Kuvhara kwepiritsi hakugoni kudzivirira mishonga chete kubva kune simba rekunze kwekunze, sekunyorova uye chiedza, asiwo kuvhara kunhuhwirira kwakashata uye kuravira kwemishonga, nokudaro kuvandudza kutevedza kwevarwere. Iyo firimu yakaumbwa neHPMC ine mvura yakanaka yekudzivisa uye simba, iyo inogona kubudirira kuwedzera hupenyu hwesherufu yemishonga.
Panguva imwecheteyo, HPMC inogona zvakare kushandiswa sechinhu chikuru chekudzora-kuburitsa membranes yekugadzirwa kweyakasimba-kuburitswa uye kudzorwa-kuburitswa mahwendefa. Iyo inopisa gel maitiro inobvumira zvinodhaka kuburitswa mumuviri panguva yakafanotemerwa yekuburitsa, nekudaro kuwana mhedzisiro yekureba-kuita zvinodhaka kurapwa. Izvi zvinonyanya kukosha mukurapa zvirwere zvisingaperi, zvakadai sezvinodiwa kwenguva refu yemishonga yevarwere vane chirwere cheshuga uye hypertension.
2. Semumiriri-yakasunungurwa-yakagadziriswa
HPMC inoshandiswa zvakanyanya seyakasimba-yakaburitswa mumiriri mukugadzirira zvinodhaka zvemuromo. Nekuti inogona kuumba gel mumvura uye gel layer inonyungudika zvishoma nezvishoma sezvo mushonga unoburitswa, inogona kunyatso kudzora kuburitswa kwemushonga. Ichi chishandiso chinonyanya kukosha mumishonga inoda kuburitswa kwenguva refu kwezvinodhaka, senge insulin, antidepressants, nezvimwe.
Munzvimbo yegumbo, gel layer yeHPMC inogona kudzora kuburitswa kwemushonga, kudzivirira kukurumidza kuburitswa kwemushonga munguva pfupi, nekudaro kuderedza mhedzisiro uye kurebesa kushanda. Ichi chivakwa-chakaburitswa chakanyanya kukodzera kurapwa kwemishonga inoda kugadzikana kweropa zvinodhaka, senge maantibioti, anti-epileptic zvinodhaka, nezvimwe.
3. Somubhainda
HPMC inowanzoshandiswa sebhainda mukugadzira piritsi rekugadzira. Nekuwedzera HPMC kune zvinodhaka zvidimbu kana hupfu, fluidity yayo uye adhesion inogona kuvandudzwa, nokudaro kuvandudza compression maitiro uye simba repiritsi. Iyo isiri-chepfu uye kugadzikana kweHPMC inoita kuti ive yakakodzera binder mumapiritsi, granules uye capsules.
4. Sezvinoita thickener uye stabilizer
Mukugadzirira kwemvura, HPMC inoshandiswa zvakanyanya seyakakora uye inodzikamisa mune dzakasiyana siyana zvinwiwa zvemuromo, madonhwe emeso uye topical creams. Nzvimbo yayo yekukora inogona kuwedzera viscosity yezvinodhaka zvinodhaka, kudzivirira stratification yezvinodhaka kana kunaya kwemvura, uye nekuona kugoverwa kwakafanana kwezvinhu zvinosanganisa zvinodhaka. Panguva imwecheteyo, lubricity uye moisturizing zvimiro zveHPMC zvinogonesa kuti inyatso kudzikisa kusagadzikana kwemaziso mumadonhwe eziso uye kudzivirira maziso kubva pakutsamwa kwekunze.
5. Inoshandiswa mu capsules
Sechirimwa-chinotorwa cellulose, HPMC ine yakanaka biocompatibility, zvichiita kuti ive chinhu chakakosha kugadzira chirimwa capsules. Kuenzaniswa neyakajairwa mhuka gelatin capsules, HPMC capsules ine kugadzikana kuri nani, kunyanya mukupisa kwepamusoro uye kunyorova kwenzvimbo, uye hazvisi nyore kukanganisa kana kunyungudika. Pamusoro pezvo, HPMC macapsules akakodzera kune varimi uye varwere vane allergic kune gelatin, kuwedzera chiyero chekushandiswa kwe capsule zvinodhaka.
(3) Zvimwe zvekushandisa zvinodhaka zveHPMC
Pamusoro pezvakajairwa pamusoro pekushandisa zvinodhaka, HPMC inogona zvakare kushandiswa mune mamwe chaiwo madhiragi. Semuenzaniso, mushure mekuvhiyiwa kwemaziso, HPMC inoshandiswa mumadonhwe emeso semafuta ekudzikisa kukweshera pamusoro peziso uye kukurudzira kupora. Pamusoro pezvo, HPMC inogona zvakare kushandiswa muzvizoro uye gels kukurudzira kutora zvinodhaka uye kuvandudza kushanda kwemishonga yemuno.
Pharmaceutical giredhi HPMC inoita basa rakakosha mukugadzirira kwezvinodhaka nekuda kwehunhu hwayo hwakanaka hwemuviri nemakemikari. Sezvo multifunctional Pharmaceutical excipient, HPMC haigoni chete kunatsiridza kugadzikana kwemishonga uye kudzora kusunungurwa kwemishonga, asiwo kuvandudza zvinodhaka kutora ruzivo uye kuwedzera murwere kutevedzera. Nekuenderera mberi kwekufambira mberi kwehunyanzvi hwekugadzira mishonga, nzvimbo yekushandisa yeHPMC ichave yakakura uye ichaita basa rakakosha mukuvandudza zvinodhaka mune ramangwana.
Nguva yekutumira: Sep-19-2024