Hydroxypropyl Methylcellulose (HPMC) inowanzoshandiswa cellulose kubva kune zvakasiyana-siyana zvekushandisa, zvakadai semushonga, chikafu, zvekuvaka uye zvekuzora. HPMC isiri-ionic, semi-synthetic, inert polymer ine yakanakisa kunyungudika kwemvura, kukora, kunamira uye firimu-kugadzira zvinhu.
Chimiro uye zvivakwa zveHPMC
HPMC is a modified cellulose inogadzirwa nereacting cellulose ine methyl chloride uye propylene oxide. Chimiro chayo chemorekuru chine zvese methyl uye hydroxypropyl zvinotsiva, izvo zvinopa HPMC yakasarudzika yemuviri uye kemikari zvimiro, senge yakanakisa solubility, colloid kudzivirira uye firimu-kugadzira zvimiro. HPMC inogona kupatsanurwa kuita akawanda mataurirwo zvichienderana neakasiyana anotsiva, uye imwe neimwe yakatarwa ine yakasiyana solubility uye inoshandisa mumvura.
Solubility yeHPMC mumvura
Dissolution mechanism
HPMC inodyidzana nemamorekuru emvura kuburikidza nehydrogen zvisungo kugadzira mhinduro. Kunyungudika kwayo kunosanganisira mamorekuru emvura zvishoma nezvishoma achipinda pakati pemaketani emamorekuru eHPMC, achiparadza kubatana kwayo, kuitira kuti cheni dzepolymer dzipararire mumvura kuti dzigadzire yunifomu mhinduro. Kunyungudika kweHPMC kwakabatana zvakanyanya nehuremu hwayo hwemamorekuru, substituent mhando uye dhigirii rekutsiva (DS). Kazhinji, iyo yakakwirira dhigirii yekutsiva iyo inotsiva, iyo inokwirisa kunyungudika kweHPMC mumvura.
Mhedzisiro yetembiricha pane solubility
Tembiricha ndechimwe chezvinhu zvakakosha zvinokanganisa kunyungudika kweHPMC. Kunyungudika kweHPMC mumvura kunoratidza hunhu hwakasiyana sezvo tembiricha inochinja:
Dissolution tembiricha range: HPMC inonetsa kunyungudika mumvura inotonhora (kazhinji pasi pe40°C), asi inogona kunyungudika nekukurumidza kana ichipisa kusvika 60°C kana kupfuura. Kune yakaderera-viscosity HPMC, tembiricha yemvura inosvika 60°C kazhinji ndiyo yakanakira kunyungudika tembiricha. Kune yakakwirira-viscosity HPMC, iyo yakakwana yekunyungudika tembiricha inogona kunge yakakwira kusvika 80°C.
Gelation panguva yekutonhodza: Kana iyo HPMC mhinduro ichipisa kune imwe tembiricha (kazhinji 60-80 ° C) panguva yekunyungudika uye yozotonhora zvishoma nezvishoma, gel rinopisa rinogadzirwa. Iyi gel inodziya inova yakagadzikana mushure mekutonhodzwa kusvika kukamuri tembiricha uye inogona kuparadzirwa zvakare mumvura inotonhora. Chiitiko ichi chakakosha zvikuru pakugadzirira kweHPMC mhinduro kune zvimwe zvinangwa (zvakadai semishonga inosimudzira-inoburitsa capsules).
Dissolution kunyatsoita: Kazhinji, tembiricha yepamusoro inogona kukurumidzira kuparara kweHPMC. Nekudaro, tembiricha yakakwira zvakare inogona kutungamira mukuderedzwa kwepolymer kana kudzikira kwekunyungudika viscosity. Naizvozvo, mukushanda chaiko, tembiricha yakakodzera yekunyungudika inofanirwa kusarudzwa sezvinodiwa kudzivirira kushatisa kusingakoshi uye shanduko yepfuma.
Mhedzisiro yepH pane solubility
Senge isiri-ionic polymer, iyo solubility yeHPMC mumvura haina kukanganiswa zvakananga ne pH kukosha kwemhinduro. Nekudaro, yakanyanyisa pH mamiriro (seakasimba acidic kana alkaline nharaunda) anogona kukanganisa kunyungudika maitiro eHPMC:
Mamiriro eAcidic: Pasi pemamiriro akasimba ane acidic (pH <3), mamwe mabhondi emakemikari eHPMC (akadai se ether bonds) anogona kuparadzwa ne-acidic medium, zvichiita kuti iite solubility uye dispersibility. Nekudaro, mune yakajairika isina kusimba acid renji (pH 3-6), HPMC inogona kuramba yakanyungudika zvakanaka. Alkaline mamiriro: Pasi pemamiriro akasimba ealkaline (pH> 11), HPMC inogona kuderedza, iyo inowanzokonzerwa nehydrolysis reaction ye hydroxypropyl chain. Pasi pemamiriro asina simba ealkaline (pH 7-9), kunyungudika kweHPMC hakuwanzo kukanganiswa.
Dissolution nzira yeHPMC
Kuti unyatso kunyungudutsa HPMC, nzira dzinotevera dzinowanzo shandiswa:
Mvura inotonhora yekuparadzira nzira: Zvishoma nezvishoma wedzera HPMC hupfu mumvura inotonhora uchikurudzira kuti iparadzire zvakaenzana. Iyi nzira inogona kudzivirira HPMC kubva yakananga agglomerating mumvura, uye mhinduro inoumba colloidal inodzivirira layer. Zvadaro, zvishoma nezvishoma kupisa kusvika 60-80 ° C kuti iparadze zvizere. Iyi nzira yakakodzera kuparara kwevakawanda HPMC.
Nzira yekuparadzira mvura inopisa: Wedzera HPMC kumvura inopisa uye kurumidzisa nekukasira kuinyungudusa nekukasira pakupisa. Iyi nzira yakakodzera kune yakakwira-viscosity HPMC, asi kutarisisa kunofanirwa kubhadharwa kudzora tembiricha kudzivirira kushatisa.
Solution pre-preparation method: Chekutanga, HPMC inonyungudutswa mune organic solvent (yakadai se ethanol), uyezve mvura inowedzerwa zvishoma nezvishoma kuishandura kuita aqueous solution. Iyi nzira yakakodzera kune yakakosha mamiriro ekushandisa ane yakakwirira solubility zvinodiwa.
Dissolution tsika mumashandisirwo anoshanda
Mumashandisirwo anoshanda, iyo disolution process yeHPMC inoda kugadziridzwa zvinoenderana nemashandisirwo chaiwo. Semuenzaniso, mumunda wemishonga, zvinowanzodikanwa kuumba yakanyanya yunifomu uye yakagadzikana colloidal mhinduro, uye kwakasimba kudzora tembiricha uye pH inodiwa kuti ive nechokwadi che viscosity uye biological chiitiko chemhinduro. Muzvivakwa zvekuvaka, kunyungudika kweHPMC kunobata zvimiro zvekugadzira firimu uye kusimba kwesimba, saka nzira yakanakisa yekunyungudika inoda kusarudzwa pamwe chete nemamiriro ekunze.
Kunyungudika kweHPMC mumvura kunokanganiswa nezvinhu zvakawanda, kunyanya tembiricha uye pH. Kazhinji kutaura, HPMC inonyungudika nekukurumidza pane tembiricha yepamusoro (60-80°C), asi inogona kudzikisira kana kunyungudika pasi pemamiriro epH akanyanya. Naizvozvo, mumashandisirwo anoshanda, zvinodikanwa kuti usarudze tembiricha yakakodzera yekunyungudika uye pH renji zvinoenderana nekushandiswa chaiko uye mamiriro ezvakatipoteredza eHPMC kuti ive nechokwadi chekunyungudika kwayo uye kuita kwayo.
Nguva yekutumira: Jun-25-2024