HPMC (hydroxypropyl methylcellulose)capsules ndeimwe yezvinowanzoshandiswa capsule zvinhu mumishonga yemazuva ano uye zvekudya zvinowedzera. Inoshandiswa zvakanyanya muindasitiri yemishonga uye indasitiri yezvigadzirwa zvehutano, uye inofarirwa nevanodya miriwo nevarwere vane allergies nekuda kwezvimiro zvayo zvakabva kumiti. HPMC capsules inonyungudika zvishoma nezvishoma mudumbu remudumbu mushure mekudya, nekudaro ichiburitsa zvinhu zvinoshanda mazviri.
1. Overview yeHPMC capsule dissolution nguva
Nguva yekuparara kweHPMC capsules inowanzova pakati pegumi nemaminitsi makumi matatu, izvo zvinonyanya kuenderana nekukora kwemadziro evhavha, maitiro ekugadzirira, chimiro chemukati wecapsule, uye zvakatipoteredza. Kuenzaniswa neyakajairwa gelatin capsules, mwero wekunyunguduka weHPMC capsules unononoka zvishoma, asi uchiri mukati mechikamu chinogamuchirwa chedumbu remunhu. Kazhinji, zvinodhaka kana mishonga inogona kukurumidza kusunungurwa uye kubatwa mushure mokunge capsule yanyungudutswa, kuve nechokwadi che bioavailability yezvinhu zvinoshanda.
2. Zvinhu zvinokanganisa chiyero chekuparara kweHPMC capsules
pH kukosha uye tembiricha
HPMC capsules ine zviri nani solubility munzvimbo dzine acidic uye dzisina kwayakarerekera, saka dzinogona kunyungudika nekukurumidza mudumbu. Iyo pH kukosha yemudumbu kazhinji iri pakati pe1.5 ne3.5, uye iyi acidic nharaunda inobatsira HPMC capsules kuparara. Panguva imwecheteyo, kutonhora kwemuviri wemuviri wemunhu (37 ° C) kunogona kukurudzira kukurumidza kupera kwema capsules. Naizvozvo, munzvimbo ine acid yemudumbu, HPMC capsules inogona kunyungudika nekukurumidza uye kuburitsa zviri mukati.
HPMC capsule madziro ukobvu uye density
Ukobvu hwemadziro ecapsule hunokanganisa zvakananga nguva yekuparara. Madhuri akakora emadziro anotora nguva yakawanda kunyungudika zvachose, nepo matete capsule madziro anonyungudika nekukurumidza. Uye zvakare, kuwanda kweiyo HPMC capsule inozokanganisa chiyero chayo chekuparara. Denser capsules inotora nguva yakareba kuti iparadze mudumbu.
Rudzi uye chimiro chezviri mukati
Izvo zvinongedzo zvakatakurwa mukati mecapsule zvakare zvine imwe mhedzisiro payero yekuparara. Semuenzaniso, kana zviri mukati zvine acidic kana soluble, iyo capsule ichanyungudika nekukurumidza mudumbu; nepo kune zvimwe zvinhu zvine mafuta, zvinogona kutora nguva yakareba kuti zviparare. Mukuwedzera, iyo yekuparara kwehuwandu hwehupfu uye hwemvura huri mukati hwakasiyanawo. Kugoverwa kwemukati memvura kwakawedzera yunifomu, iyo inobatsira kukurumidza kuparara kweHPMC capsules.
Capsule size
HPMCcapsules ezvinyorwa zvakasiyana-siyana (zvakadai seNo. Kazhinji, macapsules madiki anotora nguva pfupi kunyungudika, nepo macapsules makuru ane madziro akakora uye zvimwe zviri mukati, saka anotora nguva yakati rebei kunyungudika.
Kugadzirira nzira
Munguva yekugadzirwa kweHPMC capsules, kana mapurasitiki akashandiswa kana zvimwe zvinongedzo zvichiwedzerwa, maitiro ekunyungudika emakapisi anogona kuchinjwa. Semuyenzaniso, vamwe vagadziri vanowedzera muriwo glycerin kana zvimwe zvinhu kuHPMC kuti iwedzere kusimba kwemakapisi, izvo zvinogona kukanganisa kuparara kwemakapisi kusvika kumwero wakati.
Humidity uye kuchengetedza mamiriro
HPMC capsules inonzwa kune hunyoro uye kuchengetedza mamiriro. Kana akachengetwa munzvimbo yakaoma kana yakakwirira tembiricha, macapsules anogona kuita brittle, nekudaro achichinja chiyero chekunyungudika mudumbu remunhu. Naizvozvo, HPMC capsules kazhinji inoda kuchengetwa munzvimbo yakadzika tembiricha uye yakaoma nharaunda kuti ive nechokwadi chekugadzikana kwehuwandu hwekunyungudika uye kunaka.
3. Disolution process yeHPMC capsules
Iyo yekumisa maitiro eHPMC capsules inowanzo patsanurwa kuita matanho matatu:
Yekutanga nhanho yekunyudza mvura: Mushure mekudya, HPMC capsules inotanga kunwa mvura kubva mugastric juice. Pamusoro pe capsule inova yakanyorova uye zvishoma nezvishoma inotanga kupfava. Sezvo chimiro cheHPMC capsules chine imwe dhigirii yekunyura kwemvura, iyi nhanho inowanzo kukurumidza.
Kuzvimba uye kuparara nhanho: Mushure mekutora mvura, iyo capsule madziro zvishoma nezvishoma inoputika kuita gelatinous layer. Iri danga rinoita kuti capsule iwedzere kuparara, uye zviri mukati zvinobva zvafumurwa nekuburitswa. Iyi nhanho inotarisa chiyero chekuparara kwecapsule uye zvakare kiyi yekuburitswa kwemishonga kana chikafu.
Complete dissolution stage: Sezvo kuparara kunofambira mberi, iyo capsule inonyungudika zvachose, zviri mukati zvinosunungurwa zvizere, uye zvinogona kutorwa nemuviri wemunhu. Kazhinji mukati megumi kusvika makumi matatu maminetsi, HPMC capsules inogona kupedzisa maitiro kubva pakuparara kusvika kupedzisa kupera.
Kugadzirira nzira
Munguva yekugadzirwa kweHPMC capsules, kana mapurasitiki akashandiswa kana zvimwe zvinongedzo zvichiwedzerwa, maitiro ekunyungudika emakapisi anogona kuchinjwa. Semuyenzaniso, vamwe vagadziri vanowedzera muriwo glycerin kana zvimwe zvinhu kuHPMC kuti iwedzere kusimba kwemakapisi, izvo zvinogona kukanganisa kuparara kwemakapisi kusvika kumwero wakati.
Humidity uye kuchengetedza mamiriro
HPMC capsules inonzwa kune hunyoro uye kuchengetedza mamiriro. Kana akachengetwa munzvimbo yakaoma kana yakakwirira tembiricha, macapsules anogona kuita brittle, nekudaro achichinja chiyero chekunyungudika mudumbu remunhu. Naizvozvo, HPMC capsules kazhinji inoda kuchengetwa munzvimbo yakadzika tembiricha uye yakaoma nharaunda kuti ive nechokwadi chekugadzikana kwehuwandu hwekunyungudika uye kunaka.
3. Disolution process yeHPMC capsules
Iyo yekumisa maitiro eHPMC capsules inowanzo patsanurwa kuita matanho matatu:
Yekutanga nhanho yekunyudza mvura: Mushure mekudya, HPMC capsules inotanga kunwa mvura kubva mugastric juice. Pamusoro pe capsule inova yakanyorova uye zvishoma nezvishoma inotanga kupfava. Sezvo chimiro cheHPMC capsules chine imwe dhigirii yekunyura kwemvura, iyi nhanho inowanzo kukurumidza.
Kuzvimba uye kuparara nhanho: Mushure mekutora mvura, iyo capsule madziro zvishoma nezvishoma inoputika kuita gelatinous layer. Iri danga rinoita kuti capsule iwedzere kuparara, uye zviri mukati zvinobva zvafumurwa nekuburitswa. Iyi nhanho inotarisa chiyero chekuparara kwecapsule uye zvakare kiyi yekuburitswa kwemishonga kana chikafu.
Complete dissolution stage: Sezvo kuparara kunofambira mberi, iyo capsule inonyungudika zvachose, zviri mukati zvinosunungurwa zvizere, uye zvinogona kutorwa nemuviri wemunhu. Kazhinji mukati megumi kusvika makumi matatu maminetsi, HPMC capsules inogona kupedzisa maitiro kubva pakuparara kusvika kupedzisa kupera.
Nguva yekutumira: Nov-07-2024