Hydroxypropyl methylcellulose (HPMC), seyakajairwa cellulose derivative, inoshandiswa zvakanyanya mukuvaka, mishonga, chikafu, makemikari ezuva nezuva uye mamwe maindasitiri. Hunhu hweHPMC hunonyanya kutongwa kubva kuzvinhu zvemuviri uye zvemakemikari zvivakwa, mashandiro ekuita uye mashandiro ekushandisa.
1. Chitarisiko uye ruvara
HPMC kazhinji chena kana kure-chena upfu kana granules. Kana paine shanduko yakakosha yemuvara, senge yero, kuchena, nezvimwewo, zvinogona kureva kuti kuchena kwayo hakuna kukwirira kana kusvibiswa. Pamusoro pezvo, kuenzana kwehukuru hwechikamu kunoratidzawo huwandu hwekutonga kwemaitiro ekugadzira. Yakanaka HPMC zvimedu zvinofanirwa kugovaniswa zvakaenzana pasina agglomeration iri pachena kana tsvina.
2. Solubility test
HPMC ine mvura yakanaka solubility, inova chiratidzo chakakosha chekutonga kunaka kwayo. Kuburikidza neyedzo yakapusa yekunyungudika, kunyungudika kwayo uye viscosity inogona kuongororwa. Matanho acho ndeaya:
Tora hupfu hushoma hweHPMC, zvishoma nezvishoma uwedzere kumvura inotonhora kana tembiricha yekamuri mvura, uye cherechedza maitiro ayo ekunyungudika. Yepamusoro-mhando HPMC inofanirwa kuparadzirwa zvakaenzana munguva pfupi pasina zviri pachena kunaya kwemvura, uye pakupedzisira kuumba yakajeka kana zvishoma turbid colloidal mhinduro.
Mwero wekuparara weHPMC une hukama neyakaomesesa chimiro, dhigirii rekutsiva, uye kuchena kwemaitiro. Hunhu husina kunaka HPMC inogona kunyungudika zvishoma nezvishoma uye nyore kuita magwara anonetsa kuora.
3. Viscosity kuyerwa
Viscosity ndiyo imwe yeanonyanya kukosha paramita kune HPMC mhando. Viscosity yaro mumvura inokanganiswa nehuremu hwemamorekuru uye dhigirii rekutsiva, uye inowanzoyerwa neinotenderera viscometer kana capillary viscometer. Iyo chaiyo nzira ndeyekunyungudutsa imwe chiyero cheHPMC mumvura, kugadzirira mhinduro yeimwe yekusangana, uyezve kuyera viscosity yemhinduro. Zvinoenderana neiyo viscosity data, inogona kutongwa kuti:
Kana iyo viscosity yakakosha yakanyanya kuderera, zvinogona kureva kuti molecular uremu idiki kana yakave yakaderedzwa panguva yekugadzira maitiro;
Kana iyo viscosity kukosha yakanyanya, zvinogona kureva kuti molecular uremu hwakanyanya kana kutsiva hakuna kuenzana.
4. Kuonekwa kwakachena
Kuchena kweHPMC kuchakanganisa kushanda kwayo. Zvigadzirwa zvine kuchena kwakaderera kazhinji zvine zvimwe zvisaririra kana tsvina. Mutongo wekutanga unogona kuitwa nenzira dzinotevera dziri nyore:
Residue bvunzo pakupisa: Isa shoma shoma yeHPMC sampuli muchoto chepamusoro-soro uye uipise. Huwandu hwezvakasara hunogona kuratidza zviri mukati meinorganic munyu uye simbi ions. Yepamusoro-mhando HPMC masara anofanirwa kunge ari madiki.
pH kukosha bvunzo: Tora huwandu hwakakodzera hweHPMC woinyungudutsa mumvura, uye shandisa pH bvunzo bepa kana pH mita kuyera pH kukosha kwemushonga. Mumamiriro ezvinhu akajairwa, iyo HPMC aqueous solution inofanira kunge iri pedyo nekusarerekera. Kana iine acidic kana alkaline, tsvina kana ne-zvigadzirwa zvinogona kuvapo.
5. Thermal properties uye kugadzikana kwekushisa
Nekupisa sampuli yeHPMC, kugadzikana kwayo kwekupisa kunogona kucherechedzwa. Yepamusoro-mhando yeHPMC inofanirwa kuve neyakagadzikana yekupisa panguva yekudziya uye haifanire kuora kana kukundikana nekukurumidza. Matanho akareruka ekupisa ekuita bvunzo anosanganisira:
Pisai sampuli shoma pandiro inopisa uye cherechedzai kunyunguduka kwayo uye tembiricha yekuora.
Kana iyo sampu ikatanga kuora kana kushandura ruvara pane yakaderera tembiricha, zvinoreva kuti kugadzikana kwayo kwekupisa kwakashata.
6. Kutsunga kwehunyoro
Kunyanya kuwanda kwehunyoro hweHPMC huchakanganisa kugadzikana kwayo uye kushanda kwayo. Hunyoro hwayo hunogona kutsanangurwa nehuremu nzira:
Isa sampuli yeHPMC muovheni woiomesa pa105 ℃ kuti irambe ichirema, wobva waverenga musiyano wehuremu usati waomesa uye mushure mekuomesa kuti uwane hunyoro hwemukati. Yepamusoro-soro HPMC inofanirwa kunge iine mwando yakaderera, kazhinji inodzorwa pasi pe5%.
7. Dhigirii rekutsvaga kwekutsiva
Dhigirii rekutsiva methoxy uye hydroxypropoxy mapoka eHPMC anokanganisa zvakananga kuita kwayo, senge solubility, tembiricha yegel, viscosity, etc. Dhigirii yekutsiva inogona kutsanangurwa nekemikari titration kana infrared spectroscopy, asi nzira idzi dzakanyanya kuoma uye dzinoda kuitwa munzvimbo yerabhoritari. Muchidimbu, HPMC ine yakaderera inotsiva ine murombo solubility uye inogona kugadzira isina kuenzana gels mumvura.
8. Gel tembiricha bvunzo
Iyo tembiricha yegel yeHPMC ndiyo tembiricha yainoumba gel panguva yekudziya. Yepamusoro-soro HPMC ine chaiyo tembiricha yegel, kazhinji iri pakati pe60°C ne90°C. Iyo nzira yekuyedza yekushisa kwegel ndeye:
Dissolve HPMC mumvura, zvishoma nezvishoma kuwedzera tembiricha, uye cherechedza tembiricha apo mhinduro inochinja kubva pachena kuti turbid, inova tembiricha gel. Kana tembiricha yegel ikatsauka kubva payakajairwa, zvinogona kureva kuti chimiro chayo chemolecular kana dhigirii yekutsiva haina kuenderana.
9. Kuongororwa kwekuita
Kuita kwekushandisa kweHPMC kwezvinangwa zvakasiyana kunogona kunge kwakasiyana. Semuenzaniso, muindasitiri yekuvaka, HPMC inowanzoshandiswa sechinhu chekuchengetedza mvura uye mukobvu. Yayo kuchengetedza mvura kuita uye kukora mhedzisiro inogona kuyedzwa kuburikidza nedhaka kana putty kuyedza. Mumaindasitiri emishonga uye ezvekudya, HPMC inoshandiswa seyaimbova firimu kana capsule zvinhu, uye firimu rayo rekugadzira maitiro uye colloidal zvimiro zvinogona kuyedzwa kuburikidza nekuyedza.
10. Kunhuwa uye Kusagadzikana Zvinhu
Yemhando yepamusoro HPMC haifanirwe kunge isina munhuwi unooneka. Kana sampuli ine kunhuhwirira kunhuwa kana kuravira kwekunze, zvinogona kureva kuti makemikari asingadiwi akaunzwa panguva yekugadzira kwayo kana kuti ine zvinhu zvinopisa zvakanyanya. Mukuwedzera, yepamusoro-soro HPMC haifaniri kubudisa magasi anogumbura pakupisa kwepamusoro.
Hunhu hweHPMC hunogona kutongwa nemiedzo yakapusa senge chitarisiko, solubility uye viscosity kuyerwa, kana nemakemikari nzira senge kuchena kuyedzwa uye kupisa kwekuita bvunzo. Kuburikidza nenzira idzi, mutongo wekutanga unogona kuitwa pamhando yeHPMC, nekudaro kuve nechokwadi chekuita kwayo kwakagadzikana mumashandisirwo chaiwo.
Nguva yekutumira: Sep-25-2024