HPMC inonzi hydroxypropyl methylcellulose.
HPMC chigadzirwa inosarudza yakanyanya yakachena donje cellulose seyakagadzirwa uye inogadzirwa neakakosha etherification pasi pemamiriro ealkaline. Iyo yese maitiro inopedzwa pasi pemamiriro eGMP uye otomatiki yekutarisa, pasina chero inoshanda zvinhu senge nhengo dzemhuka uye girizi.
HPMC zvivakwa:
HPMC chigadzirwa haisi-ionic cellulose ether, chitarisiko chichena chehupfu, chisina kunhuhwirira, chinonyungudika mumvura uye yakawanda polar organic solvents (senge dichloroethane) uye chikamu chakakodzera che ethanol / mvura, propyl doro / mvura, nezvimwewo. basa, kujeka kwepamusoro uye kushanda kwakagadzikana. HPMC ine zvimiro zveiyo thermal gel, mhinduro yemvura yechigadzirwa inodziya kuti igadzire gel kunaya, uye yozonyungudika mushure mekutonhora, zvirevo zvakasiyana zvechigadzirwa gel tembiricha zvakasiyana. Solubility inoshanduka ne viscosity, iyo yakadzika iyo viscosity, iyo yakakura kunyungudika, akasiyana mataurirwo eHPMC ane mutsauko muzvinhu zvayo, HPMC mumvura haina kukanganiswa nePH kukosha. Particle size: 100 mesh pass rate yakakura kupfuura 100%. Kuwanda kwehuwandu: 0.25-0.70g/ (kazhinji inenge 0.5g/), giravhiti chaiyo 1.26-1.31. Discoloration tembiricha: 190-200 ℃, carbonization tembiricha: 280-300 ℃. Kushushikana kwepamusoro: 42-56dyn / cm mu 2% mhinduro ine mvura. Nekuwedzera kwemethoxyl yemukati, iyo gel point yakadzikira, kunyungudika kwemvura kwakawedzera, uye chiitiko chepamusoro chakawedzerawo. HPMC ine hunhu hwekukora, salting, yakaderera madota, kugadzikana kwePH, kuchengetedza mvura, kugadzikana kwedimensional, yakanakisa firimu kuumba uye kuramba kwakanyanya kune enzyme, kupararira uye kubatana.
HPMC Applications:
1. Kuvhara kwehwendefa: HPMC inoshandiswa semafirimu ekuputira zvinhu mukugadzirira kwakasimba, inogona kuumba yakaoma, yakatsetseka uye yakanaka firimu, kushandiswa kwekushandiswa kwe2% -8%. Mushure mekuputira, kugadzikana kwemumiririri kune chiedza, kupisa uye humidity kunowedzera; Haina kunaka uye isinganhuhwi, iri nyore kutora, uye HPMC pigment, sunscreen, lubricant uye kumwe kuenderana kwakanaka kwezvinhu. Ordinary coating: mvura kana 30-80% ethanol kunyungudutsa HPMC, pamwe 3-6% mhinduro, achiwedzera ebetsero zvinhu (zvakadai: ivhu tembiricha -80, castor mafuta, PEG400, talc, etc.).
2. Enteric-soluble coating isolation layer: pamusoro pemapiritsi uye granules, HPMC yekuputira inotanga kushandiswa seyepasi yekuputira isolation layer, uye inoputirwa nehupamhi hweHPMCP enteric-soluble material. HPMC firimu inogona kuvandudza kugadzikana kweenteric-soluble coating agent mukuchengetedza.
3. Kugadziriswa-kusunungurwa kwekugadzirira: kushandisa HPMC se pore-inducing agent uye kuvimba ne ethyl cellulose se skeleton zvinhu, kusunungurwa-kusunungurwa kwenguva refu mahwendefa anogona kuitwa.
4. Thickening agent uye colloid inodzivirira inonamira uye madonhwe emeso: HPMC yehupfu inowanzoshandiswa kuungana kwe0.45-1%.
5. Adhesive: HPMC sebhinder general concentration ye2% -5%, inoshandiswa kuvandudza kugadzikana kwehydrophobic adhesive, inowanzoshandiswa 0.5-1.5%.
6. Kunonoka mumiririri, inodzorwa kuburitsa mumiriri uye mumiriri wekumisa. Suspension agent: yakajairika dosage yekumisa mumiriri ndeye 0.5-1.5%.
7. Zvokudya: HPMC semumiriri wekukora akawedzerwa kune zvakasiyana-siyana zvekunwa, zvigadzirwa zvemukaka, zvinonaka, zvokudya zvinovaka muviri, seagentining, binder, emulsifier, suspension agent, stabilizer, mvura yekuchengetedza mvura, excifer, nezvimwewo.
8. Inoshandiswa mune zvizorwa seadhesives, emulsifiers, film forming agents, nezvimwewo.
Nguva yekutumira: Jan-14-2022