Hydroxyethylcellulose (HEC) isiri-ionic, inonyungudika nemvura polima inotorwa kubva muselulosi. Yayo yakasarudzika kemikari chimiro uye zvimiro zvinoita kuti ive chinhu chinogoneka nekushandisa kwakasiyana mumaindasitiri akadai semishonga, zvekuzora, chikafu, uye kutarisirwa wega. Imwe yeayo inocherechedzwa hunhu ndeye yakanakisa kumiswa zvimiro, izvo zvinotora basa rakakosha mune akawanda maumbirwo.
Chimiro uye Zvivakwa zveHEC
HEC inotorwa kubva ku cellulose, inova inongoitika polima inowanikwa muchirimwa sero madziro. Kuburikidza nenhevedzano yemaitiro emakemikari, mapoka ehydroxyethyl anounzwa pane cellulose musana, zvichikonzera polima inonyungudika nemvura ine zvimiro zvakasiyana.
Mushonga Wemakemikari: Chimiro che cellulose chinosanganisira kudzokorora zvikamu zveglucose zvakabatanidzwa pamwe chete ne β-1,4-glycosidic bonds. MuHEC, mamwe emapoka e-hydroxyl (-OH) pazvikamu zveglucose anotsiviwa nemapoka e-hydroxyethyl (-OCH2CH2OH). Kutsiva uku kunopa kunyungudika kwemvura kune polymer uku ichichengeta musana weiyo cellulose.
Kunyungudika kweMvura: HEC inonyungudika zvakanyanya mumvura, ichigadzira mhinduro dzakajeka, dze viscous. The degree of substitution (DS), iyo inoratidza avhareji yenhamba yemapoka ehydroxyethyl paglucose unit, inokanganisa kunyungudika kwepolymer nezvimwe zvinhu. Huwandu hweDS hwepamusoro hunowanzokonzera kunyungudika kukuru kwemvura.
Viscosity: HEC mhinduro dzinoratidza pseudoplastic maitiro, zvichireva kuti viscosity yavo inoderera pasi pekunetseka kweshear. Ichi chivakwa chinobatsira mukushandisa senge machira uye zvinonamira, uko zvinhu zvinoda kuyerera zviri nyore panguva yekushandisa asi chengetedza viscosity kana uchizorora.
Firimu Kugadzira: HEC inogona kuumba akajeka, anochinjika mafirimu kana akaomeswa, ichiita kuti ive yakakodzera kushandiswa semugadziri wekugadzira firimu mumashandisirwo akasiyana siyana.
Kumiswa Zvivakwa zveHEC
Kuturika (Suspension) zvinoreva kugona kwechinhu chakasimba kuramba chakaparadzirwa zvakaenzana mukati memvura inoyerera pasina kugadzika nekufamba kwenguva. HEC inoratidza yakanakisa kumiswa zvivakwa nekuda kwezvinhu zvakati wandei:
Hydration uye Kuzvimba: Kana HEC zvimedu zvaparadzirwa mukati memvura, inonyudza uye kuzvimba, ichigadzira matatu-dimensional network inoteya nekumisa zvimedu zvakasimba. Iyo hydrophilic chimiro cheHEC inofambisa kukwira kwemvura, zvichiita kuti iwedzere viscosity uye yakagadziridzwa kumiswa kugadzikana.
Particle Size Distribution: HEC inogona kunyatso kumisa huwandu hwakasiyana hwemasikirwo saizi nekuda kwekugona kwayo kugadzira network ine akasiyana mesh saizi. Izvi zvakasiyana-siyana zvinoita kuti zvive zvakakodzera kumisa zvese zvakanaka uye zvakakasharara zvimedu mumhando dzakasiyana siyana.
Thixotropic Behaviour: HEC mhinduro dzinoratidza thixotropic maitiro, zvichireva kuti viscosity yavo inoderera nekufamba kwenguva pasi pekugara kushear kunetseka uye kupora kana kushushikana kwabviswa. Ichi chivakwa chinobvumira kudururira nyore uye kushandisa uku uchichengetedza kugadzikana uye kumiswa kwezvimedu zvakasimba.
pH Kugadzikana: HEC yakagadzikana pamusoro pehuwandu hwepH hutsika, ichiita kuti ive yakakodzera kushandiswa mune acidic, neutral, uye alkaline formulations pasina kukanganisa maitiro ayo ekumisa.
Zvikumbiro zveHEC muKumiswa Mafomu
HEC yakanakisa kumiswa zvivakwa inoita kuti ive chinhu chakakosha muzvigadzirwa zvakawanda mumaindasitiri akasiyana:
Paints uye Coatings: HEC inoshandiswa seyakakora uye inomisa mumiriri mumvura-yakavakirwa pendi uye machira kudzivirira kugadzika kwe pigment uye zvinowedzera. Iyo pseudoplastic maitiro inofambisa yakatsetseka application uye yunifomu kufukidzwa.
Personal Care Zvigadzirwa: Mushamposi, kugezeswa kwemuviri, uye zvimwe zvigadzirwa zvekutarisira zvemunhu, HEC inobatsira kumisa zvidimbu zvemukati senge exfoliants, pigments, uye mabheji anonhuhwirira, kuve nechokwadi kunyangwe kugovera uye kugadzikana kwekuumbwa.
Pharmaceutical Formulations: HEC inoshandiswa mukumiswa kwemishonga kumisa zvinhu zvinoshanda uye kuvandudza kunaka uye kugadzikana kweoral liquid dosage mafomu. Kuenderana kwayo neyakasiyana siyana yeAPIs (Active Pharmaceutical Ingredients) uye excipients inoita kuti ive sarudzo yakasarudzika yevagadziri.
Chikafu uye Chinwiwa Zvigadzirwa: HEC inoshandiswa mumashandisirwo echikafu senge saradhi madhirezi, sosi, uye zvinwiwa kumisa zvisinganyunguriki senge herbs, zvinonhuwira, uye pulp. Hunhu hwayo husina hwema uye husina kunaka hunoita kuti ive yakakodzera kushandiswa mukugadzira chikafu pasina kukanganisa hunhu.
Hydroxyethylcellulose (HEC) i polymer inoshanda zvakasiyana-siyana ine yakasarudzika kumiswa zvivakwa, zvichiita kuti ive chinhu chakakosha muhuwandu hwakasiyana hwekuumbwa mumaindasitiri. Kugona kumisa zvimedu zvakasimba zvakaenzana mumidhiya yemvura, pamwe chete nezvimwe zvinodikanwa senge kunyungudika kwemvura, viscosity control, uye pH kugadzikana, zvinoita kuti zvive zvakakosha kune vanogadzira vari kutsvaga kuwana zvakagadzikana uye zvemhando yepamusoro zvigadzirwa. Sezvo kuedza nekusimudzira kuri kuramba kuchienderera mberi, mashandisirwo eHEC mukumisa mafomu anotarisirwa kuwedzera mberi, kutyaira hunyanzvi uye kuwedzera kushanda kwechigadzirwa muzvikamu zvakasiyana.
Nguva yekutumira: Chivabvu-09-2024