Dunhu: Kuunganidza Zvinhu; Membrane zvinyorwa; Kumhanya-kwakadzorwa polymer zvinhu zvekugadzirira zvishoma-zvishoma nezvishoma; Kusimbisa mumiririri; Kumiswa rubatsiro, piritsi piritsi; Yakasimbiswa ADhishenion mumiriri.
1. Chigadzirwa Nhanganyaya
Ichi chigadzirwa chisiri-ionic cellelose ether, kunze kwekunze kweupfu hwechena, kusavimbika uye kusarongeka mumvura uye kuzvimba kwemvura inotonhora kuti uzive kana zvishoma turbided courlidal solution. Iyo mhinduro yemvura ine nzvimbo yemusoro, yakakwira transparency uye yakagadzikana kuita. HPMC ine pfuma yeiyo inopisa gel. Mushure mekupiswa, iyo yekugadzirisa mhedzisiro mhinduro inoumba maGel chairo, uye wozonyungudika mushure mekutonhora. Tembiricha yegwenzi redzidziso dzakasiyana dzakasiyana. Solubility Shanduko neViscosity, Viscosity Zhao Low, iyo Solubility yeHPMC Zvivakwa zvine mamwe mutsauko, HPMC yakanyungudutswa mumvura haina kukanganiswa ne pH kukosha.
Iko kusarudzika kwekushambadzira tembiricha, kusununguka kwakasununguka, yechokwadi density uye girazi tembiricha yaive 360 ℃, 0731g / cm3, cm3 uye 170 ~ 180 ℃, zvichiteerana. Mushure mekupenga, inoshandura brown pa190 ° C uye Burns pa 225 ~ 230 ° C.
HPMC iri kuda kusakwana mu chloroform, ethanol (95%), uye difethyl erthanol naMethyrol uye methylene chloride, uye musanganiswa wemvura uye ethanol. Mamwe maungira eHPMC anonyura mumabhodhi eacetone, methlelene chloride, uye 2-pranan, pamwe mune mamwe organic sol.
Tafura 1: Tekiniki Zviratidzo
chirongwa
Gauge,
60 GD (2910).
65GD (2906)
75gd (2208)
Madaro%
28.0-32.0
27.0-30.0
19.0-24.0
Hydroxyprisheni%
7.0-12.0
4.0-7.5
4.0-12.0
Gel tembirity ℃
56-64.
62.0-68.0
70.0-90.0
Viscosity mpa s.
3,5,6,15,50,4000
50400 0
100400 0150 00100 000
Dry uremu kurasikirwa%
5.0 kana zvishoma
Kupisa zvakasara%
1.5 kana zvishoma
pH
4.0-8.0
Simbi inorema
20 kana zvishoma
Arsenic
2.0 kana zvishoma
2. Zvigadzirwa zvechigadzirwa
2.1 Hydroxyprupropyl methylcellose inopera mumvura inotonhora kuti iite viscous coolution. Chero bedzi ichiwedzerwa kumvura inotonhora uye zvishoma zvakamutswa, zvinogona kunyimwa mumhinduro inoonekera. Kusiyana neizvozvo, zvakanyatsonaka mumvura inopisa pamusoro 60 × uye inogona kungozvimba. Mukugadzirira kwehydroxyprusyl methicellose mhinduro yemvura, zvakanyatsonaka
22
2.3 HYDROXYPROPYL MetHylcellose ine yakasimba anti-kunzwa kwekunzwa, uye nekuwedzera kwekutsiva kwemanyorerwo mumanyorerwo, anti-sensitivity anowedzerwa. Zvinodhaka uchishandisa HPMC SEZVINHU ZVINOGONESESA ZVINHU ZVINOGONESESA ZVIMWE ZVAKAWANDA ZVIMWE ZVIMWE ZVINOGONA KUPEDZISIRA ZVIMWE ZVAKAITWA (Starch, Dextrin, Shuga yePow).
2.4 hydroxypruppropyl methylcellose inoenderana nest. Semhando yemishonga yemishonga, haina metabolized kana kubatikana, saka haina kupa kupisa mune zvinodhaka uye chikafu. Iyo ine yakasarudzika yekushandisa kune yakaderera Calorific kukosha, munyu-wakasununguka, asiri-allergenic zvinodhaka uye chikafu cheshuga.
2.5HPMC ine chakagadzikana kune acids uye zvigadziko, asi kana ph inopfuura 2 ~ 11 uye inokanganiswa nekudziya kwakakwirira kana nguva yekuchengetedza, ichaderedza degree rekurera.
2.6 Hydroxyprusyl Methylcellose Soluce Solution inogona kupa mamiriro epasi, kuratidza mwero pamusoro uye nhengo dzehunyanzvi hwekunzwisisa. Iyo ine emulsifiti inoshanda mune maviri-chikamu system uye inogona kushandiswa seanobudirira stabilizer uye inodzivirira collid.
2.7 hydroxyprupylpropyl methylcellose mhinduro yemvura ine zvinhu zvakanakisa-zvinoumba-mafirimu ekuumba, uye zvinhu zvakanaka zvinovhara zvemahwendefa nemapiritsi. Iyo membrane yakaumbwa naro haina ruvara uye yakaoma. Kana glycerol inowedzerwa, mapurasitiki ayo anogona kuwedzerwa. Mushure mekurapwa kwepasi, chigadzirwa chakapararira mumvura inotonhora, uye chiyero chekunyungudutswa chinogona kudzorwa nekuchinja-pl nzvimbo. Iyo inoshandiswa mukugadziriswazve-kugadzirira gadziriro uye gadziriso-dzakasarudzika gadziriro.
3. Chigadzirwa Chigadzirwa
3.1. Inoshandiswa seanonamatira uye yekuzvidza mumiririri
HPMC inoshandiswa kusimudzira kudhakwa kwezvinodhaka uye degree rekusunungurwa, rinogona kunyungudutswa neHPMC rakanyungudutswa ZVINODA, iyo general ndeye 2% ~ 5%.
HPMC mhinduro yemhedzisiro uye imwe yekuvharirwa kwe ethanol kuita comosite yekubatanidza; MUFANANIDZO: 2% HPMC Mvura Mhinduro yakasanganiswa ne 55% Ethanol Solution yakashandiswa kune iyo yekuvheneka yeAmoxicillin Capsules Capsules yakawedzera kubva pamakumi matatu neshanu kusvika 90% isina HPMC.
HPMC inogona kugadzirwa nemanyoro inonamatira nekumisikidzwa kwakasiyana kwehunhu smarrry mushure mekuparadzwa; Iko kupaza kweErythromycin Enter-coated mapiritsi akawedzera kubva pamakumi matatu nemakumi matatu nemakumi matatu muzana kusvika ku97.38% kana 2% HPMC uye 8% starch yakasanganiswa.
2.2. Gadzira firimu kuunganidza zvinhu uye firimu kugadzira zvinhu
HPMC sechinhu-chema-soluble coating zvinhu zvine hunhu hunotevera: zvine mwero solution viscossity; Maitiro ekubatanidza ari nyore; Firimu rakanaka kugadzira zvinhu; Inogona kuchengeta chimiro chechikamu, kunyora; Inogona kunyorova; Inogona ruvara, kururamisa flon. Ichi chigadzirwa chinoshandiswa sefirimu-soluble firimu yekuvhara mahwendefa nemapiritsi neyakaderera viscosity, uye kune isina-mvura-based firimu yekuvhara neyekutanga viscosity, iyo mari yekushandisa ndeye 2% -5%.
2.3, seanomiririra mumiririri uye collidal dziviriro glue
HPMC yakashandiswa seyekukakavara ndeye 0.45% ~ 1.0%, inogona kushandiswa seyeziso madonhwe uye yekubvarura kubvaruka mumiririri; Inoshandiswa kuwedzera kugadzikana kwehydrophobic glue, kudzivirira kusvitsa chidimbu, chakasarudzika, iyo nguva yakajairwa ndeye 0.5% ~ 1.5%.
2.4, seblocker, inononoka kuburitsa zvinhu, inodzorwa kuburitswa mumiriri uye pore mumiririri
HPMC yakakwira viscosity modhi inoshandiswa kugadzirira mabhuruku uye anodzorwa vabati vamiriri akasanganiswa eSkeleton akasimbiswa masisitoni ekusimudzira mahwendefa uye hydrophilic gel sotlet sununguko dzakasimbiswa. Iyo yakadzika-vcosity modhi ndeyekudzikisira kwemazamu ekusunungurwa
2,5. Gel uye suppository matrix
Hydrogel suppositories uye gastric chinhambadziro gadziriro inogona kugadzirirwa nekushandisa hunhu hwe hydrogelumberi kugadzirwa kunowanzoshandiswa neHPMC mumvura.
2.6 Biological Anonalive Zvinhu
Metronidazole yaisanganiswa neHPMC uye Polycarboxyleylone 934 mumusanganiswa kuti iite mabhegi ekudzorwa ebioparled ane 250mg. Mu vitro dissolution bvunzo yakaratidza kuti kugadzirira nekukurumidza mumvura, uye kusunungurwa kwezvinodhaka kwakadzorwa nehana uye carbon keteni yekuzorora. Kuitwa kwemhuka kwakaratidza kuti iyo itsva inodhaka yekuburitsa system yaive yakakosha biological adhishsion gadziriso kuti ibuke muCofa Mucosa.
2.7, sekumiswa rubatsiro
Iyo yakakwira viscosity yechigadzirwa ichi chinhu chakanaka chekumiswa rubatsiro rwekumiswa kwemvura gadziriro, iyo nguva yayo yakajairwa ndeye 0.5% ~ 1.5%.
4. Kushandisa Mienzaniso
4.1 Firimu Coating Solution: HPMC 2KG 2KG 2KG 2kg, Castor Of 1000ml Pane nzira mbiri dzekuigadzira.
4.1.1 Gadzirira pigment yakanyungudutswa Sanganisa 80% yemhinduro (20% yekupukuta) ine huwandu hwakatemerwa hwechifuta chemafuta, pakati-pakati-80, uye profyleye glycol.
4.1.2 Kugadzirira kweInsoluble pigment (senge simbi oxidee) kuunganidzira mvura HPMC yakadzika mu95% Ethanol Overnight, uye mvura yakawedzerwa kuti iite 2% HPMC yakajeka mhinduro. 20% yemhinduro iyi yakabviswa pakupukuta, uye iyo inosara 80% mhinduro uye yesimbi yemhando yakagadzirirwa nemvura yekukuya, uyezve huwandu hwezvimwe zvinhu zvakawedzerwa uye zvakasanganiswa zvisina mwero zvekushandisa. Maitiro ekubatanidza emvura inovhara
4.2D-Interferon ziso membrane membrane 50μg yeiyo α-interferon yakavezwa muna 10ml0.01ml hydrochlor acid uye 00mlpmc, yakaiswa patsvimbo yegirazi inotenderera, yakaomeswa pa60 ℃ uye yakaoma mumhepo. Ichi chigadzirwa chinoitwa mune zvinyorwa zvefirimu.
4.3 COTRimoxazole Mahwendefa (0.4g ± 0.08g) Smz (80 Mesh) 40kg (8% HPMC Makwikwi 0.3kg) 8KG Nepfungwa dzakatarisirwa Ichi chigadzirwa chinonyanya kushandiswa sechibhoni. Iko kupaza mahwendefa yaive 96% / 20min.
4.4 PIPERATE PLILET (0.25G) PIPERATE 80 mesh 25kg, starch (120 mesh) 2.1kg, magnesium steatate yakakodzera huwandu. Nzira yayo yekugadzira ndeye kusanganisa Pipeoperec acid, starch, ne 20% Ethanol Zviyo, pamwe ne100m Circular belt izwi (PPA0.25) STAMPING MABHUKU. Nes starching mumiririri wekusatenderwa, iyo yekunyungudika yeiyo piritsi iri isiri pasi pe80% / 2min, iyo yakakwira kupfuura zvigadzirwa zvakafanana muJapan.
4.5 Kubvaruka kweHPMC-4000, HPMC-4500 kana HPMC-5000 0.4G, Potassium 0.19% Ammonium chlorylammonium. Nzira yayo yeHPMC yakaiswa mumvura 15ML, pa80 ~ 90 【 C kusvika 8.6 ° C. Ichi chigadzirwa chinoshandiswa kubviswa kwemisodzi, chinomiririra kubvaruka kwemberi, kana uchishandiswa zvakafanira nzvimbo yechigadzirwa ichi, 0.7% ~ 1.5% yakakodzera.
4.6 MethtHorphan akadzora mabhatani meththorphan sald Yakagadzirirwa sematafura nenzira yakajairika. Ichi chigadzirwa chinoshandiswa sekudzorwa kwakadzorwa.
4.7 Yevantomycin ⅳ mahwendefa, 2149g Avantomycin Iyo yakaomeswa granules 52G hydroxypressLELLELLELLELELELELELELE, uyezve 7.5g Magnesium Stearate akawedzerwa kumahwendefa kuti aenderere mberi nekuburitswa kweVanguard Myings. Ichi chigadzirwa chinoshandiswa sekusunungura zvinhu zvishoma.
4.8 Nifedipine yakasimba-sununguko granules 1 chikamu nifrepine, 3 zvikamu hydroxpremyl methlose cellyl (ethanol: methanol Mari yekuburitsa zvinodhaka yekuburitsa haina kukanganiswa nekushandurwa kwePet uye yaive inononoka kupfuura iyo yekushambadzira magirazi anenge aripo. Mushure memaawa gumi nemaviri ekutonga kwemuromo, iro reropa revanhu raive gumi nemaviri (ml / ml, uye pakanga pasina mutsauko wega wega.
4.9 Purnhaol Hydrochloride yakasungirirwa SHEPULE CAPSUL HYDRANHAL HYDRANHAL HYDRANHALLE 60KG, Microcrystalline Cellulose 40KG, kuwedzera mvura ye50l kugadzira magirazi. HPMC1KG uye EC 9kg yaive yakasanganiswa solvent (methanol = methanol = 1: 1) Imwe neimwe capsule ine 160mg yePritranolol hydrochloride sperial sperical zvimedu.
4.10 NAPROLOL HCL SCLETON PALILETS yakagadzirirwa neSisming Naprolol HCL: HPMC: CMC-na kuRatio ye1: 0.25. Iyo yezvinodhaka yekuburitsa yaive padyo ne zero zero mukati maawa gumi nemaviri.
Zvimwe zvinodhaka zvinogona kugadzirwawo nemidziyo yakasanganiswa yeSkeoprolet, HPMC: CMC-Na Maererano na: 1: 1.25: 1.25; Allylprolol: HPMC maererano ne1: 2.8: 2.92 ratio. Iyo yezvinodhaka yekuburitsa yaive padyo ne zero zero mukati maawa gumi nemaviri.
4.11 Skeleton mahwendefa ezvekushandisa kweTetylamomosine akagadziriswa nenzira yakajairika ichishandisa micro yeiyo filda silica gel: Cmc-na: HPMC 1: 0.7: 4.3: 0.7: 4.3 Mushonga wacho unogona kusunungurwa kune gumi nevaviri mu vitro uye mu vivo, uye mutsara wekuburitsa muenzaniso waive necrelation yakanaka. Mhedzisiro yeiyo yakakurumidza kugadzikana bvunzo zvichienderana neFD Mitemo inofanotaura kuti hupenyu hwekuchengetedza hwechigadzirwa ichi kusvika pamakore maviri.
4.12 HPMC (50mpa · (5 zvikamu), HPMC (4000 Mpa · · · · · · · · ·) uye HPC1 yakavezwa muzvikamu mazana mashanu, Ichi chigadzirwa chine 80% yemushonga mukuru.
4.13 Theophylline Hydrophilic Gel Mahwendefa eSkeleteto akagadziridzwa,
Kutumira Nguva: Kukadzi-05-2020