Hydroxypropyl Methylcellulose Phthalate(HPMCP) yakagadziridzwa cellulose derivative iyo inowanzoshandiswa muindasitiri yemishonga. Inotorwa kubva kuHydroxypropyl Methylcellulose (HPMC) kuburikidza nekumwezve kugadziridzwa kwemakemikari nephthalic anhydride. Iyi gadziriso inopa yakasarudzika zvivakwa kune iyo polymer, ichiita kuti ive yakakodzera kune chaiwo mashandisirwo mukugadzira zvinodhaka.

Heano maitiro akakosha uye mashandisirwo eHydroxypropyl Methylcellulose Phthalate:

1. Enteric Coating:
   • HPMCP inoshandiswa zvakanyanya senge enteric coating material ye oral dosage mafomu akadai semapiritsi nemakapisi.
   • Enteric coatings yakagadzirirwa kuchengetedza mushonga kubva kune acidic nharaunda yemudumbu uye kufambisa kuburitswa munzvimbo ine alkaline yemukati mudiki.
2. pH-inotsamira Solubility:
   • Imwe yeakasarudzika maficha eHPMCP ndeye pH-inotsamira solubility. Iyo inoramba isinganyunguriki munzvimbo dzine acidic (pH pazasi 5.5) uye inonyungudika mumamiriro ealkaline (pH pamusoro pe6.0).
   • Ichi chivakwa chinobvumira iyo enteric-yakavharwa dosage fomu kuti ipfuure nemudumbu isina kuburitsa mushonga uye yobva yanyungudika muura nekuda kwekutora zvinodhaka.
3. Gastric Resistance:
   • HPMCP inopa gastric resistance, kudzivirira mushonga kuti uburitswe mudumbu umo unogona kuderedzwa kana kukonzera kushatirwa.
4. Kuburitswa Kunodzorwa:
   • Mukuwedzera kune enteric coating, HPMCP inoshandiswa mukudzorwa-kuburitswa kwemaitiro, zvichibvumira kunonoka kana kuwedzera kuburitswa kwemushonga.
5. Kuenderana:
   • HPMCP inowanzoenderana nemhando dzakasiyana dzemishonga uye inogona kushandiswa mumhando dzakasiyana dzemishonga.

Izvo zvakakosha kuti uzive kuti nepo HPMCP ichishandiswa zvakanyanya uye inoshanda enteric coating material, kusarudzwa kwe enteric coating kunoenderana nezvinhu zvakaita semushonga chaiwo, inodiwa kuburitsa chimiro, uye zvinodiwa nemurwere. Vagadziri vanofanirwa kufunga nezve physicochemical zvimiro zvezvese mushonga uye iyo enteric coating zvinhu kuti uwane inodiwa mhedzisiro yekurapa.

Sezvinoita chero chinhu chemishonga, zvimiro zvemitemo uye nhungamiro zvinofanirwa kuteverwa kuve nechokwadi chekuchengetedza, kushanda, uye kunaka kwechigadzirwa chekupedzisira chemishonga. Kana iwe uine mibvunzo chaiyo pamusoro pekushandiswa kweHPMCP mune imwe mamiriro ezvinhu, zvinokurudzirwa kubvunza nhungamiro yemishonga ine chekuita nemishonga kana vane masimba.