Hydroxypropylmethylcellulose (HPMC) i polymer inoshanda zvakasiyana-siyana iyo inoshandiswa zvakanyanya mumaindasitiri akasiyana siyana nekuda kwekusiyana kwayo. Mushonga uyu unobva ku cellulose, polima yemusikirwo inowanikwa mumadziro esero rezvirimwa. Iyo synthesis yeHPMC inosanganisira kurapa cellulose nepropylene oxide kuunza hydroxypropyl mapoka uye nemethyl chloride kuunza methyl mapoka. Iyo polymer inoguma inoratidza huwandu hwakasiyana hwemuviri uye makemikari zvimiro, zvichiita kuti ive yakakodzera kushandiswa mumishonga, kuvaka, chikafu uye mamwe maindasitiri.
1.Chemical chimiro uye kuumbwa:
Hydroxypropyl methylcellulose is a semi-synthetic polymer ine yakaoma makemikari chimiro. Musana wepolymer une cellulose, mutsara mutsara wemamorekuru eglucose akabatanidzwa ne β-1,4-glycosidic bond. Iro hydroxypropyl boka rinounzwa nekutsiva iyo hydroxyl boka (-OH) neboka repropyl, uye boka remethyl rinounzwa nenzira yakafanana. Iyo dhigirii yekutsiva (DS) inomiririra avhareji yenhamba yehydroxypropyl uye methyl mapoka paglucose unit uye inokanganisa kunyungudika, viscosity, uye kupisa kwezvinhu zvepolymer.
2. Solubility:
Imwe yeakasarudzika maficha eHPMC maitiro ayo ekumisa. Inonyungudika mumvura inotonhora uye inopisa, ichipa mabhenefiti akasiyana mumhando dzakasiyana dzekushandisa. Solubility inogona kugadziridzwa nekugadzirisa dhigirii rekutsiva uye huremu hwemamorekuru epolymer. Ichi chivakwa chinoita kuti HPMC ive yakanakisa mumiriri weanodzorwa-kuburitsa-anoburitsa zvinodhaka masisitimu, uko chiyero chekuparara chinoita basa rakakosha mukuburitsa zvinodhaka kinetics.
3. Viscosity:
Hydroxypropyl methylcellulose inowanikwa mumhando dzakasiyana-siyana dze viscosity, zvichienderana nezvinhu zvakadai sema molecular uremu, dhigirii rekutsiva, uye kugadzirisa kugadzirisa. Iyo viscosity yeHPMC mhinduro inovatendera kuti ishandiswe mune akawanda maindasitiri ekushandisa, kusanganisira mishonga yemishonga, seyakakora mune yemvura dosage mafomu, uye semafirimu-ekugadzira zvinhu zvekupfeka.
4. Kuita firimu-kugadzira:
Iyo firimu-kugadzira kugona kweHPMC yakakosha mumashandisirwo akadai sekuputira zvinodhaka, uko inoshandiswa kupa chidziviriro chekudzivirira kuvharidzira kuravira kwezvinodhaka, kudzora kuburitswa kwezvinodhaka, uye kugadzirisa kugadzikana. Mafirimu eHPMC akajeka uye anochinjika, uye zvimiro zvavo zvinogona kugadzirwa nekugadzirisa polymer concentration, molecular uremu uye plasticizer zvirimo.
5. Thermal performance:
Hydroxypropyl methylcellulose inoratidza kugadzikana kwakanaka kwekupisa mukati meiyo tembiricha yemhando. Thermal zvimiro zvinokanganiswa nezvinhu zvakaita sedhigirii rekutsiva, huremu hwemamorekuru, uye kuvapo kweplasticizers. Zvinhu izvi zvinoita kuti HPMC ikwane kune zvikumbiro uko kugadzikana kwekupisa kwakakosha, sekugadzirira kupisa-sensitive pharmaceutical formulations.
6. Biocompatibility:
Muminda yemishonga uye biomedical, biocompatibility chinhu chakakosha kutariswa kwezvinhu zvinoshandiswa muhurongwa hwekuunza zvinodhaka. Hydroxypropyl methylcellulose inowanzoonekwa yakachengeteka uye ine yakanaka biocompatibility. Inoshandiswa zvakanyanya mukugadzira mafomu emumuromo, maophthalmic mhinduro uye inodzorwa-inoburitsa dhizaini masisitimu.
7. Kuchengeta mvura uye kukora zvivakwa:
Kugona kweHPMC kuchengetedza mvura nekukora zvigadziriso zvinoita kuti ive yakakosha mumidziyo yekuvaka senge simende-based zvigadzirwa. Mumashandisirwo aya, HPMC inoshanda senge inochengetedza mvura, inovandudza mashandiro uye kudzivirira kuoma kwechinhu chacho nguva isati yakwana. Kukora zvivakwa zvinoshandiswawo mune dzakasiyana siyana zvigadzirwa zvechikafu kuti uwedzere kuumbwa uye muromo.
8. Kuendeswa kwezvinodhaka kunodzorwa:
Imwe yeakakosha mashandisirwo ehydroxypropyl methylcellulose iri mukugadzirwa kweanodzorwa-kuburitsa-anoburitsa zvinodhaka masisitimu. Iyo polymer's solubility, viscosity, uye firimu-kugadzira zvivakwa zvinogonesa kudzorwa kuburitswa kwezvinodhaka, zvichiita kuti zvinodhaka zvirambe zviripo uye zvakanangwa. Izvi zvinonyanya kubatsira pakuvandudza kutevedza kwevarwere uye kuderedza mhedzisiro inobatanidza nekukurumidza kuburitswa kwezvinodhaka.
9. Kugadzikana pasi pezvakasiyana pH nharaunda:
HPMC inoratidzira kugadzikana pamusoro pehupamhi pH renji, ichiita kuti ive yakakodzera kuumbwa kunoda kugadzikana pasi peacidic kana alkaline mamiriro. Ichi chivakwa chinobatsira mumishonga nekuti magadzirirwo emishonga anogona kusangana akasiyana pH nharaunda mudumbu remukati.
10. Rheological properties:
Iyo rheological maitiro eHPMC mhinduro akakosha kune maapplication uko kuyerera zvivakwa zvakakosha, senge mukugadzirira kwekupotera, zvinonamira uye gels. Iyo rheological zvimiro zvinogona kugadzirwa nekugadzirisa iyo yekumisikidza uye molecular huremu hweHPMC kuti iwane kuyerera maitiro anodiwa kune chaiyo e-control.
Hydroxypropyl methylcellulose yave yakakosha polima mumaindasitiri akasiyana nekuda kwemusanganiswa wayo wakasiyana wekunyungudika, viscosity, kugona kugadzira firimu uye biocompatibility. Kuita kwayo kwakasiyana-siyana kunoita kuti ive yakakodzera kushandiswa kwakasiyana-siyana, kubva kumishonga uye zvekuvaka kusvika kune zvekudya uye zvekuzora. Sezvo vaongorori vachiramba vachiongorora maumbirwo matsva uye mashandisirwo, zvimiro zvehydroxypropyl methylcellulose pasina mubvunzo zvichabatsira mukufambira mberi muminda dzakasiyana siyana, kuve nechokwadi chekuenderera kwayo kukosha mune zvesainzi uye indasitiri.
Nguva yekutumira: Jan-10-2024