Hydroxypropylmethylcellulose (HPMC) igadziriso yekugadzira cellulose, yakasikwa polymer inowanikwa muchirimwa sero madziro. Nepo HPMC pachayo isiri iyo biopolymer sezvo ichigadzirwa nemakemikari, inowanzoonekwa semi-Synthetic kana yakagadziridzwa biopolymers.
A. Nhanganyaya yehydroxypropyl methylcellulose:
Hydroxypropyl methylcellulose (HPMC):
Hydroxypropylmethylcellulose (HPMC) inobva kune cellulose, mutsara wepolymer inoumbwa nezvikamu zveglucose. Cellulose ndiyo inonyanya kuumbwa chikamu chechirimwa masero madziro. HPMC inogadzirwa nemakemikari ekugadzirisa cellulose nekuwedzera hydroxypropyl uye methyl mapoka.
B. Chimiro nekuita:
1.Chemical chimiro:
Iyo kemikari chimiro cheHPMC ine cellulose backbone units ine hydroxypropyl uye methyl mapoka. Degree of substitution (DS) inoreva avhareji yenhamba yehydroxypropyl uye methyl mapoka paglucose unit mucheni ye cellulose. Ichi chigadziriso chinoshandura chimiro chemuviri uye chemakemikari zvimiro zveselulosi, zvichikonzera kuwanda kweHPMC mamakisi ane akasiyana viscosities, solubility uye gel zvivakwa.
2.Physical properties:
Solubility: HPMC inonyungudika mumvura uye inogadzira mhinduro dzakajeka, zvichiita kuti ive chinhu chakakosha mukushandisa kwakasiyana siyana kunosanganisira mishonga, chikafu, uye kuvaka.
Viscosity: Iyo viscosity yeHPMC mhinduro inogona kudzorwa nekugadzirisa dhigirii rekutsiva uye huremu hwemamorekuru epolymer. Ichi chivakwa chakakosha kune zvikumbiro zvakaita semagadzirirwo emishonga uye zvekuvaka.
3. Basa:
Thickeners: HPMC inowanzoshandiswa seyakakora muzvikafu, mishonga, uye zvigadzirwa zvekuchengeta munhu.
Kugadzira Firimu: Inogona kuumba mafirimu uye inogona kushandiswa kuvhara mahwendefa emishonga uye makapisi, pamwe nekugadzira mafirimu ekushandisa kwakasiyana.
Kuchengeta Mvura: HPMC inozivikanwa nekuchengeta kwayo mvura, ichibatsira kuvandudza kushanda uye hydration yezvinhu zvekuvaka senge simende-based zvigadzirwa.
C. Kushandiswa kweHPMC:
1. Zvinodhaka:
Tablet Coating: HPMC inoshandiswa kugadzira machira emapiritsi kudzora kuburitswa kwezvinodhaka uye kugadzirisa kugadzikana.
Oral drug delivery: Iyo biocompatibility uye inodzorwa kuburitsa zvimiro zveHPMC inoita kuti ive yakakodzera kune yemuromo yekutumira zvinodhaka masisitimu.
2.Indasitiri yekuvaka:
Doka uye Simende Zvigadzirwa: HPMC inoshandiswa mukuvaka zvinhu kusimudzira kuchengetedza kwemvura, kushanda uye kunamatira.
3. Indasitiri yezvekudya:
Thickeners uye Stabilizers: HPMC inoshandiswa seyakakora uye inodzikamisa muzvikafu kuvandudza magadzirirwo uye kugadzikana.
4. Zvigadzirwa zvekuchengeta wega:
Cosmetic Magadzirirwo: HPMC inosanganisirwa mune zvizorwa magadzirirwo eiyo firimu-kugadzira uye kukora zvimiro.
5.Paints uye Coatings:
Mabhanhire emvura: Muindasitiri yekupfekedza, HPMC inoshandiswa mukugadzirwa kwemvura kuvandudza rheology uye kudzivirira pigment kugadzika.
6. Mafungiro ezvakatipoteredza:
Nepo HPMC pachayo isiri iyo yakazara biodegradable polymer, kwayakatangira cellulosic inoita kuti ive ine hushamwari hwezvakatipoteredza kana ichienzaniswa nemapolymer akazara ekugadzira. HPMC inogona biodegrade pasi pemamwe mamiriro, uye kushandiswa kwayo mune inoenderera uye biodegradable maumbirwo inzvimbo yekuenderera mberi kwekutsvaga.
Hydroxypropylmethylcellulose (HPMC) iine multifunctional semi-synthetic polymer inotorwa kubva ku cellulose. Hunhu hwayo hwakasiyana hunoita kuti ive yakakosha mumaindasitiri akasiyana siyana anosanganisira emishonga, kuvaka, chikafu, kuzvitarisira uye pendi. Kunyangwe isiri iyo yakasarudzika nzira yebiopolymer, mavambo ayo cellulose uye biodegradation inogona kuenderana nekukura kuri kudiwa kwezvinhu zvinogoneka mumashandisirwo akasiyana. Tsvagiridzo inoenderera mberi ichitsvaga nzira dzekusimudzira kuenderana kwezvakatipoteredza kweHPMC uye kuwedzera mashandisiro ayo mumagariro ane hushamwari maumbirwo.
Nguva yekutumira: Feb-07-2024