Ko hypromellose acid inodzivirira here?

Hypromellose, inozivikanwawo se hydroxypropyl methylcellulose (HPMC), haisati yagara acid-resistant. Nekudaro, iyo acid kuramba yehypromellose inogona kukwidziridzwa kuburikidza neakasiyana maitiro ekugadzira.

Hypromellose inonyungudika mumvura asi haina kunyungudika muorganic solvents uye isiri-polar zvinwiwa. Naizvozvo, munzvimbo dzine acidic, senge mudumbu, hypromellose inogona kunyungudika kana kuzvimba kune imwe nhanho, zvichienderana nezvinhu zvakaita sehuwandu hweasidhi, pH, uye nguva yekuratidzwa.

Kuti uvandudze kupikisa kweasidhi ye hypromellose mukugadzirwa kwemishonga, maitiro ekugadzira enteric anowanzo shandiswa. Enteric coatings inoshandiswa pamapiritsi kana capsules kuti ivadzivirire kubva munzvimbo ine acidic yemudumbu uye inobvumira kuti ipfuure munzvimbo isina kwayakarerekera yemukati mudiki isati yaburitsa zvinhu zvinoshanda.

Enteric coatings inowanzogadzirwa kubva kumapolymers anoramba gastric acid, senge cellulose acetate phthalate (CAP), hydroxypropyl methylcellulose phthalate (HPMCP), kana polyvinyl acetate phthalate (PVAP). Aya mapolymers anoumba chipingamupinyi chekudzivirira chakatenderedza piritsi kana capsule, kudzivirira kupera nguva isati yakwana kana kudzikira mudumbu.

Muchidimbu, nepo hypromellose pachayo isiri asidi-resistant, acid yayo kuramba inogona kukwidziridzwa kuburikidza nemaitiro ekugadzira senge enteric coating. Aya matekiniki anowanzo shandiswa mukugadzirwa kwemishonga kuti ive nechokwadi chekuunza kunoshanda kwezvishandiso zvinoshandiswa kunzvimbo inotarirwa kuita chiito mumuviri.