Hydroxyprupyl methylcellose (HPMC) Iyo inowanzoshandiswa polymer yakajairika, inoshandiswa zvakanyanya mukuvaka, mishonga, chikafu uye mamwe maindasitiri. Semukati memvura-sollummer polymer, HPMC ine yakanakisa kudzokorora kwemvura, firimu-inoumba, inokonzeresa uye inofungidzira zvivakwa. Kuchengetwa kwemvura kwayo ndeimwe yezvivakwa zvaro mune zvakawanda zvekushandisa, kunyanya muzvinhu zvakadai sedanda, mucheche mune yekuvaka maindasitiri, iyo inogona kunonoka kubuda kwemvura uye kuvandudza mashandiro ekuvaka uye kunaka kwechigadzirwa chekupedzisira. Nekudaro, kuchengetwa kwemvura kweHPMC kwakanyatsoenderana nekushisa kwekudziya munzvimbo dzekunze, uye kunzwisisa hukama uhu kwakakosha kuchishandiswa kwayo muminda dzakasiyana.
1. Kuchengeterwa uye kuchengetwa kwemvura kweHPMC
HPMC inogadzirwa nemakemikari yekugadziridzwa kwechisikigo cellulose, kunyanya nekutanga kwehydroxypropyl (-c3h7Oh) uye methyl (-ch3) mapoka muCellulose Chain, iyo inopa iyo yakanaka yekunyaradza uye yekutonga zvinhu. Iyo hydroxyl mapoka (-OOH) muHPMC mamorekuru inogona kuumba hydrogen zvisungo zvine mamorekuru. Naizvozvo, HPMC inogona kutora mvura uye kusanganisa mvura, kuratidza kuchengetwa kwemvura.
Kuchengetwa kwemvura kunoreva kugona kwechinhu kuti chengetedze mvura. Kune HPMC, zvinonyanya kuratidzwa mukukwanisa kwayo kuchengetedza zvemvura muhurongwa hwekuita hydration, kunyanya mukudziya kwakanyanya, izvo zvinokanganisa zvinobudirira kurasikirwa kwemvura uye chengetedza iyo yakanyorova yezvinhu. Sezvo hydration muHPMC mamorekuru inoenderana neyakawirirana neyaro molecular chimiro, shanduko dzekutonga dzinozokanganisa zvakananga kuti mvura isingawedzere uye kuchengetwa kwemvura yeHPMC.
2. Mhedzisiro ye tembiricha pakuchengetwa kwemvura yeHPMC
Hukama pakati penzvimbo yemvura yeHPMC uye tembiricha inogona kukurukurwa kubva pane zviviri zvikamu: Imwe ndiyo mhedzisiro yekushisa pane iyo solubl yeHPMC, uye imwe mhedzisiro yekushisa pane yayo manyorosi uye hydration.
2.1 Mhedzisiro ye tembiricha pane iyo solubility yeHPMC
Iyo solubility yeHPMC mumvura ine chekuita nekushisa. Kazhinji, iyo solubility yeHPMC inowedzera nekuwedzera tembiricha. Kana tembiricha ikatiza, mamorekuru emvura anowana simba rinowedzera simba, rikakonzerwa nekusagadzikana kwekudyidzana pakati pemamorekuru emvura, nokudaro anokurudzira kupaza kwe Hpc. Kune HPMC, kuwedzera tembiricha kunogona kuita kuti zvive nyore kuumba mhinduro ye collodal, nekukasira kuchengetwa kwemvura yaro mumvura.
Nekudaro, zvakanyanyisa kupisa tembiricha inogona kuwedzera iyo visikopa yeHPMC solution, inokanganisa zvivakwa zvaro uye kuparadzaniswa. Kunyangwe mhedzisiro iyi iri yakanaka yekuvandudzwa kwekunyanyisa, kwakanyanya kupisa kunogona kuchinja kugadzikana kweiyo molecular chimiro uye kutungamira kuderera kwekuchengetwa kwemvura.
2.2 Mhedzisiro ye tembiricha pane iyo molecular chimiro cheHPMC
Muchimiro cheMOLECAR Sezvo tembiricha inowedzera, simba reiyo hydrogen chisungo chingachinja, zvichikonzera kushaya simba kwesimba rekusunga pakati peHPMC mamorekuru uye nekukonzera kuchengetwa kwaro kwemvura. Kunyanya, kuwedzera kwe tembiricha kuchakonzera iyo hydrogen zvisungo muHPMC molecule yekuparadzanisa, nekudaro ichidzora mvura yayo uye nekuchengetwa kwemvura.
Uye zvakare, iyo tembiricha yekunzwa yeHPMC inoratidzwawo muchikamu chechipfungawo chekugadzirisa kwayo. HPMC ine akasiyana ma molecular maseru uye akasiyana mapoka ekutsiva ane akasiyana ekuwaridza sensitive. Kazhinji kutaura, yakaderera molecular uremu hpmc iri kutarisisa kune tembiricha, nepo yakakwira molecular uremu HPMC inoratidzira yakawanda yakagadzikana kuita kwakasimba. Naizvozvo, mune zvinoshanda zvinoshandiswa, zvakakodzera kusarudza iyo yakakodzera HPMC mhando zvinoenderana neyakajeka tembiricha yekudziya kuti ive yekuchengetwa kwayo yekuchengetwa kwemvura kune yekudziya kwemvura.
2.3 Mhedzisiro yekupisa pakubuda kwemvura
Mune yakanyanya tembiricha, iyo yekuchengetwa kwemvura yeHPMC ichakanganiswa neyakakurumidza kubuda mvura yemvura inokonzerwa nekuwedzera kwekushisa. Kana iyo yekunze tembiricha yakanyanya kukwirira, mvura iri muHPMC System inowanzoita kuti udzokere. Kunyangwe HPMC inogona kuchengeta mvura kusvika kune imwe nzira yemanyorerwo, zvakanyanya kupisa kwakanyanya kunogona kukonzera iyo system yekukonzera mvura nekukurumidza kupfuura kuchengetedza kwemvura kune hpmc. Mune ino kesi, kuchengetwa kwemvura kweHPMC kunorambidzwa, kunyanya munzvimbo dzakanyanya tembiricha uye yakaoma nzvimbo.
Kuti uderedze dambudziko iri, zvimwe zvidzidzo zvakaratidza kuti kuwedzera zvikwata zvakakodzera kana zvimwe zvinhu zvakave nekugadziriswa mune formula zvinogona kuvandudza kuchengetwa kwemvura kweHPMC mune yakanyanya tembiricha yemamiriro ekunze. Semuenzaniso, nekugadzirisa iyo viscosity modifier mune formula kana kusarudza yakaderera solvent, iyo yekuchengetwa kwemvura yeHPMC inogona kuvandudzwa kune imwe nhanho, kudzora mhedzisiro yekuwedzera kwekubereka kwemvura.
3. Kufurira zvinhu
Mhedzisiro yekupisa kwemvura pane iyo HPMC inoenderana kwete chete pane iyo ambient tembiricha pachayo, asiwo pane iyo srea huremu, degree rekutsiva uye zvimwe zvinhu zveHPMC. Semuyenzaniso:
Solley Huremu:Hpc Nehuremu hwepamusoro hune huremu hunowanzove nekuchengetwa kwemvura zvine simba, nekuti dhizaini yematokisi yakaumbwa nemaketeni makuru emamolecular uremu mumhinduro inogona kutora uye kuchengetedza mvura zvakanyanya.
Dare rekutsiva: Iyo degree reMethylation uye hydroxypruslation yeHPMC ichakanganisa kudyidzana kwayo nemamolekora emvura, nekudaro anokanganisa kuchengetwa kwemvura. Kazhinji, danho repamusoro rekutsiva rinogona kusimudzira hydrophilicity yeHPMC, nekudaro achivandudza kuchengetwa kwemvura yayo.
Kugadzirisa mhinduro: Kusvina kweHPMC kunobatawo kuchengetwa kwaro kwemvura. Nzvimbo dzakakwirira dzeHPMC Solutions dzinowanzove nemvura yekuchengetwa kwemvura, nekuti yakanyanya kutarisisa yeHPMC inogona kuchengetedza mvura kuburikidza nekusimba kwekusimbisa kwekudyidzana.
Iko kune hukama hwakaoma pakati pekuchengetwa kwemvuraHpcuye tembiricha. Kuwedzera tembiricha kunowanzo kusimudzira solubility yeHPMC uye kunogona kutungamira pakuvandudza kuchengetedza kwemvura, asi kwakanyanyisa kupisa kuchaputsa chimiro cheHPMC, kuderedza kugona kusunga mvura, uye nekudaro kukanganisa mari yekuchengeta kwavo. Kuti uzadzise iyo yakanakisa mvura yekuchengetwa kwemvura pasi pemamiriro akasiyana ekushisa Uye zvakare, zvimwe zvikamu muFomula uye tembiricha yekudzidzira nzira zvinogona zvakare kuvandudza kuchengetwa kwemvura kweHPMC mune yakanyanya tembiricha kune imwe nhanho.
Kutumira Nguva: Nov-11-2024