Hydroxypropyl methylcellulose (HPMC) inowanzoshandiswa polymer compound, inoshandiswa zvakanyanya mukuvaka, mishonga, chikafu uye mamwe maindasitiri. Semvura inonyungudika polymer, HPMC ine yakanakisa kuchengetedza mvura, firimu-kuumba, kukora uye emulsifying zvivakwa. Kuchengetedzwa kwayo kwemvura ndechimwe chezvinhu zvayo zvakakosha mumashandisirwo mazhinji, kunyanya mune zvinhu zvakaita semende, dhaka uye machira muindasitiri yekuvaka, izvo zvinogona kunonoka kubuda kwemvura uye kuvandudza mashandiro ekuvaka uye kunaka kwechigadzirwa chekupedzisira. Nekudaro, kuchengetwa kwemvura kweHPMC kwakabatana zvakanyanya nekuchinja kwekushisa munzvimbo yekunze, uye kunzwisisa hukama uhu kwakakosha pakushandiswa kwayo munzvimbo dzakasiyana.
1. Mamiriro uye kuchengetedza mvura kweHPMC
HPMC inogadzirwa nekugadziriswa kwemakemikari echisikigo cellulose, kunyanya nekuiswa kwehydroxypropyl (-C3H7OH) uye methyl (-CH3) mapoka muketani ye cellulose, iyo inopa iyo yakanaka solubility uye zvigadziriso zvinhu. Mapoka ehydroxyl (-OH) ari muHPMC mamorekuru anogona kuumba mahydrogen bond nemamorekuru emvura. Naizvozvo, HPMC inogona kutora mvura uye kusanganisa nemvura, kuratidza kuchengetedza kwemvura.
Kuchengeta mvura zvinoreva kugona kwechinhu kuchengeta mvura. Kune HPMC, inonyanya kuratidzwa mukukwanisa kwayo kuchengetedza zvinyorwa zvemvura muhurongwa kuburikidza ne hydration, kunyanya mukupisa kwepamusoro kana kunyorova kwepamusoro, izvo zvinogona kudzivirira kuparara nokukurumidza kwemvura uye kuchengetedza kunyorova kwechinhu. Sezvo iyo hydration mumamorekuru eHPMC iri padhuze nekudyidzana kweiyo molecular chimiro, shanduko yetembiricha inokanganisa zvakananga kunyudza kwemvura uye kuchengetwa kwemvura kweHPMC.
2. Mhedzisiro yekushisa pakuchengetedza mvura kweHPMC
Hukama huri pakati pekuchengetedza mvura kweHPMC uye tembiricha inogona kukurukurwa kubva pamativi maviri: imwe mhedzisiro yetembiricha pane solubility yeHPMC, uye imwe ndiyo mhedzisiro yetembiricha pane yayo molecular chimiro uye hydration.
2.1 Mhedzisiro yekushisa pane solubility yeHPMC
Kunyungudika kweHPMC mumvura kunoenderana nekupisa. Kazhinji, iyo solubility yeHPMC inowedzera nekuwedzera tembiricha. Kana tembiricha yakwira, mamorekuru emvura anowana simba rinopisa rakawanda, zvichikonzera kupera simba kwekudyidzana pakati pemamorekuru emvura, nokudaro zvichikurudzira kuparara kwemvura. HPMC. Kune HPMC, kuwedzera kwekushisa kunogona kuita kuti zvive nyore kugadzira colloidal solution, nokudaro kuwedzera kuchengetwa kwayo kwemvura mumvura.
Nekudaro, yakanyanya kupisa tembiricha inogona kuwedzera viscosity yeHPMC mhinduro, inokanganisa rheological maitiro uye dispersibility. Kunyange zvazvo chiitiko ichi chiri chakanaka pakuvandudzwa kwekunyungudika, kutonhora kwakanyanya kunogona kuchinja kugadzikana kwemaitiro ayo emakemikari uye kutungamirira mukuderera kwekuchengetedza mvura.
2.2 Mhedzisiro yekushisa pane iyo molecular chimiro cheHPMC
Mumamolecular chimiro cheHPMC, ma hydrogen bond anonyanya kuumbwa nemamorekuru emvura kuburikidza nemapoka ehydroxyl, uye iyi hydrogen bond yakakosha pakuchengetedza mvura kweHPMC. Sezvo tembiricha inowedzera, simba rehydrogen bond rinogona kushanduka, zvichikonzera kupera simba kwesimba rinosunga pakati peHPMC molecule uye mvura molecule, zvichikanganisa kuchengetedza kwayo mvura. Kunyanya, kuwedzera kwekushisa kunokonzeresa kuti hydrogen zvisungo muHPMC molecule isiyane, nekudaro ichidzikisa kunyura kwayo kwemvura uye simba rekuchengetedza mvura.
Uye zvakare, iyo tembiricha senitivity yeHPMC inoratidzwa zvakare muchikamu chemaitiro emhinduro yayo. HPMC ine akasiyana mamolecular uremu uye akasiyana substituent mapoka ane akasiyana kupisa sensitivities. Kazhinji kutaura, yakaderera mamorekuru huremu HPMC inonyanya kunzwa tembiricha, nepo yakakwira molecular uremu HPMC inoratidza kuita kwakadzikama. Naizvozvo, mumashandisirwo anoshanda, zvinodikanwa kusarudza iyo yakakodzera HPMC mhando zvinoenderana neyakajeka tembiricha renji kuti ive nechokwadi chekuchengeta kwayo mvura patembiricha yekushanda.
2.3 Mhedzisiro yetembiricha pakubuda kwemvura
Munzvimbo yekupisa kwepamusoro, kuchengetwa kwemvura kweHPMC kunokanganiswa nekukasira kwemvura kubuda kunokonzerwa nekuwedzera kwekushisa. Kana tembiricha yekunze yanyanya kukwira, mvura iri muHPMC system inowanzobuda. Kunyangwe HPMC ichikwanisa kuchengetedza mvura kusvika pamwero wakati kuburikidza neyakaomesesa chimiro, yakanyanya kupisa tembiricha inogona kuita kuti sisitimu irasikirwe nemvura nekukurumidza kupfuura simba rekuchengetedza mvura reHPMC. Muchiitiko ichi, kuchengetwa kwemvura kweHPMC kunodziviswa, kunyanya munzvimbo yakakwirira yekupisa uye yakaoma.
Kuti kuderedze dambudziko iri, zvimwe zvidzidzo zvakaratidza kuti kuwedzera humectants yakakodzera kana kugadzirisa zvimwe zvikamu mufomura kunogona kuvandudza mhedzisiro yemvura yeHPMC munzvimbo yekupisa. Semuenzaniso, nekugadzirisa iyo viscosity modifier mune fomula kana kusarudza yakaderera-inoputika solvent, kuchengetwa kwemvura kweHPMC kunogona kuvandudzwa kune imwe nhanho, kuderedza mhedzisiro yekuwedzera tembiricha pakubuda kwemvura.
3. Kufurira zvinhu
Mhedzisiro yekushisa pakuchengetedza kwemvura kweHPMC haibvi chete pane ambient tembiricha pachayo, asiwo pahuremu hwemamorekuru, dhigirii rekutsinhanisa, kugadzirisa kugadzirisa uye zvimwe zvinhu zveHPMC. Semuyenzaniso:
Molecular uremu:HPMC ine huremu hwepamusoro hwemamorekuru kazhinji hune simba rekuchengetedza mvura, nekuti mambure etiweki akaumbwa nemacheni akareba eremu mumhinduro anogona kutora uye kuchengetedza mvura zvakanyanya.
Dhigirii rekutsinhanisa: Iyo dhigirii yemethylation uye hydroxypropylation yeHPMC ichakanganisa kusangana kwayo nemamorekuru emvura, nekudaro ichikanganisa kuchengetwa kwemvura. Kazhinji kutaura, dhigirii repamusoro rekutsiva rinogona kuwedzera hydrophilicity yeHPMC, nekudaro ichivandudza kuchengetwa kwayo kwemvura.
Solution concentration: Iko kusungirirwa kweHPMC kunokanganisawo kuchengetedza kwayo mvura. Kukwirira kwepamusoro kweHPMC mhinduro kunowanzo kuve nekuchengetedza mvura kuri nani, nekuti yakanyanya kuwanda kweHPMC inogona kuchengetedza mvura kuburikidza nekubatana kwakasimba kweintermolecular.
Pane hukama hwakaoma pakati pekuchengetedza mvura yeHPMCuye tembiricha. Kuwedzera tembiricha kunowanzo kusimudzira kunyungudika kweHPMC uye kunogona kutungamira mukunatsiridza kuchengetwa kwemvura, asi yakanyanya kupisa tembiricha ichaparadza mamolecular chimiro cheHPMC, kuderedza kugona kwayo kusunga kumvura, uye nekudaro kukanganisa kwayo kuchengetedza kwemvura. Kuti uwane yakanakisa kuchengetedza kwemvura kuita pasi pemamiriro ekushisa akasiyana, zvinodikanwa kusarudza yakakodzera HPMC mhando zvichienderana nezvinodiwa zvekushandisa uye kugadzirisa zvine musoro mamiriro ayo ekushandisa. Uye zvakare, zvimwe zvikamu mufomula uye tembiricha nzira dzekudzora tembiricha dzinogona zvakare kuvandudza kuchengetwa kwemvura kweHPMC munzvimbo dzakanyanya tembiricha kusvika pamwero wakati.
Nguva yekutumira: Nov-11-2024