HydroxyPropyl methylcellose (HPMC) inzira inoverengeka inoshandiswa zvakanyanya mumasango akasiyana siyana nekuda kwezvivakwa zvaro zvakasarudzika. Semunhu cellulose derivative, HPMC inotorwa kubva kune yakasikwa cellulose uye ine hydroxypruppropyl uye methyl mapoka akasungirirwa kune cellulose backbone. Uku kushandurwa kunopa HPMC Kunobatsira Zvivakwa, Kuiita Izvo Zvakakodzera Kuti Urambe Zvakashandiswa Zvekushandisa, kusanganisira mishonga yemishonga, kuvaka, chikafu, uye zvigadzirwa zvekutarisira.
Kusarudza giredhi rakakodzera reHPMC kwakashora kuti uzadzise mashandiro anodikanwa mune chaiyo application. Zvinhu zvinoverengeka zvinokonzeresa hpmc kusarudzwa, kusanganisira viscosity, methxy uye hydroxypruspropyl zvemukati, kutsiva mhando, uye size. Mune iyi nhaurirano, isu tichaongorora zvinhu izvi uye tiongorore kuti vanokanganisa sei Hpmc kusarudzwa kwezvinhu zvakasiyana.
1. Viscosity:
Imwe yeiyo mainonyanya kufunga kana ichisarudza HPMC ndeye zvavakaita. Viscosity zvinoreva kupokana kwemvura kuyerera. MuHPMC, viscosity chiyero chekobvu kana kusawirirana kwemhinduro. ZvakasiyanaENT Zvikumbiro zvinoda akasiyana viscosity mamakisi eHPMC. Semuyenzaniso:
Pharmaceuticals: MuMishonga Formacal Formons, HPMC inowanzoshandiswa seyakakora uye ine ganda mumiririri. Sarudzo yegirini giredhi rinoenderana neyekuda kugadzirwa kwechigadzirwa chekupedzisira, kungave mahwendefa, makapini kana mafomu ekugadzira.
Kuvaka: Muindasitiri yekuvaka, HPMC inoshandiswa zvakanyanya mumusanganiswa wakaoma musanganiswa. Iyo viscosity yeHPMC inobata kuchengetwa kwemvura, kushanda uye kushandira kudzikisira kwemutya. Vertical zvikumbiro zvinowanzo sarudza yepamusoro viscosity mamakisi ekudzivirira sag.
2. Nzira uye hydroxyprupyl zvemukati:
Dhigirii rekutsiva Dzakasiyana DS Changes inogona kutungamira to shanduko mukunyura, gelation, uye zvimwe zvinhu. Kufungisisa kunosanganisira:
Mafirimu ekutenderera mumishonga: HPMC ine yakaderera metroxl zvemukati zvinowanzoda zvezvipenga zvefirimu mune mishonga yemishonga nekuti inovandudza midziyo yemafirimu uye inoderedza zvivakwakuitirwa kumamiriro ekunze.
3. Rimwe mhando:
Tsiva rudzi chimwe chinhu chakakosha. HPMC inogona kunyungudutsira nekukurumidza (zvakare inonzi "kukurumidza hydration") kana kunyungudusa zvishoma nezvishoma. Sarudzo inoenderana neiyo yekuburitsa chimiro inodiwa mune iyo mishonga application. Semuyenzaniso:
Kudzoserwa Kuburitswa Kuburitswa: Kwekudzorwa Kuburitswa Kwemakamuri, Kunonoka Kuparadza mamakisi eHPMC kunogona kuve kwakasarudzwa kuti uwane kusunungurwa kusunungurwa kweiyo inoshanda pharmaceutical ingreNDIVIRI.
4.
Saizi yechikuru inokanganisa kupararira uye solubility yeHPMC mumhinduro. Finer zvidimbu zvinowanzonyungudza zviri nyore, zvichikanganisa maitiro ese mune dzakasiyana siyana dzekushandisa:
Indasitiri yechikafu: Mune indasitiri yekudya, HPMC inoshandiswa mukushandisa zvakadai sekuremerwa uye kusimbisa. Zvakanaka-zviyoEd HPMC inowanzofarirwa neyakakurumidza hydration uye kupararira zvivakwa mukudya kwekudya.
5. Kuenderana nezvimwe zvinoshandiswa:
Kuenderana kweHPMC pamwe nezvimwe zvinongedzo mukuumbwa kwakakosha kuita kwayo. Izvi zvinosanganisira kuenderana neiyo inoshanda mishonga mishonga (APSI) mumishonga kana kuenderana nezvimwe zvinowedzera mukuvakwa.
Zvigadzirwa zvinodhaka: HPMC inofanira be inoenderana neAPI kuti ive nechokwadi chekugadzikana uye yunifomu kugoverwa mukati meiyo dosge fomu.
6. Regulatory kutevedzera:
Kune mishonga yechechi uye zvekudya, kutevedzera kutevedzera kwakakosha. Iyo HPMC giredhi rakasarudzwa rinofanira kutevedzera neiyo yakakodzera pharmacoopeia kana chikafu chinowedzera.
Zvinodhaka uye Chikafu: Kuteerana nezvematanho ezvimedu (semuenzaniso, USP, EP, JP) kana chikafu chinowedzerans (semuenzaniso, fda mitemo) yakakosha kuve nechokwadi chekuchengetedza uye kushanda.
7. Kufunga nezve:
Mutengo kurangarira kunoshanda mune chero maindasitiri ekushandisa. Paunenge uchisarudza giredhi rekurudyi reHPMC, kuyera maitiro ekuita uye zvinofungidzirwa mutengo zvakadzora.
Indasitiri yekuvaka: Mune indasitiri yekuvaka, HPMC inoshandiswa zvakanyanya mune yakaoma musanganiswa mafomu ekugadzira, uko kushanda kwemutengo kwakakosha kufunga.
Kusarudzwa kwakakodzera kwehydroxyprupyletl methylcellose kunoda kunyatsofungisisa zvinhu zvakasiyana, kusanganisira viscosity, sizeypropropyl yezvinyorwa, sizexypropropyl. Chishandiso chimwe nechimwe chine zvinodiwa chaizvo, uye kusarudza iyo chaiyo HPMC giredhi inosimbisa kuita kwayo uye inodiwa hunhu hwechigadzirwa chekupedzisira. Zvinokurudzirwa kushanda nevatengesi uye vagadziri vanogona kupa tsigiro yehunyanzvi uye nhungamiro yekukubatsira iwe kusarudza iyo HPMC giredhi rakanyatsokodzera chikumbiro chako chaicho.
Kutumira Nguva: Jan-02-2024