Cellulose ether (Cellulose Ether) inhengo yepolymer yakatorwa kubva kune yakasikwa chirimwa cellulose uye inowanikwa kuburikidza nekugadzirisa kemikari. Kune mhando dzakawanda dze cellulose ether, pakati peiyo hydroxypropyl methylcellulose (HPMC) ndiyo inonyanya kuzivikanwa. HPMC ine yakanakisa kunyungudika kwemvura, kukora, kumiswa, kugadzira firimu uye kugadzikana, uye inoshandiswa zvakanyanya mukuvaka, mishonga, chikafu uye zuva nezuva zvigadzirwa zvemakemikari.
1. Muviri uye makemikari zvinhu zveHPMC
HPMC inotorwa nekutsiva iyo hydroxyl chikamu mu cellulose chimiro ne methoxy uye hydroxypropoxy. Iyo ine yakanaka solubility yemvura uye inogona kukurumidza kunyungudika mumvura inotonhora kuti iite yakajeka uye viscous colloidal mhinduro, uye mhinduro yayo inoratidza kumwe kugadzikana kwekupisa pakupisa kwakasiyana. Pakudzika kwakadzika, mhinduro yeHPMC inoita sepseudoplastic fluid, zvinoreva kuti ine rheological properties, uye viscosity inoderera kana ichikurudzira kana kushandisa kushushikana, asi viscosity inopora nokukurumidza mushure mokunge simba ramira.
Iyo viscosity yeHPMC inogona kudzorwa nekugadzirisa iyo molecular huremu uye dhigirii rekutsiva, izvo zvinoita kuti inyatso kuchinjika mukushandisa munzvimbo dzakasiyana. Panyaya yekuvandudza kugadzikana kwechigadzirwa, HPMC inogona kuita basa kuburikidza nenzira dzinotevera.
2. Nzira dzeHPMC dzekuvandudza kugadzikana kwechigadzirwa
Kukora uye rheological regulation
Seyakakora, HPMC inogona kuwedzera zvakanyanya viscosity yemhinduro kana slurries, nekudaro ichiwedzera iyo viscosity kugadzikana kweiyo system. Kune zvimwe zvigadzirwa zvinoda kudzora kuyerera, senge machira, zvizorwa, uye kumiswa kwemishonga, HPMC inogona kubatsira kudzivirira zvimedu zvakasimba kubva pakugadzirisa uye kuwedzera hupenyu hwesherufu yechigadzirwa. Mukuwedzera, iyo pseudoplasticity yeHPMC inobvumira chigadzirwa kuti chirambe chakagadzikana panguva yekuchengetedza nekufambisa, uye inofambisa kuyerera uye kushandiswa kana kuchishandiswa.
Kumiswa uye kupararira kugadzikana
Mune mamwe masisitimu akapararira, kudzikamiswa kweakasimba masisitimu kana madonhwe emafuta mune yemvura midhiya ndiyo kiyi yekukanganisa kunaka kwechigadzirwa. HPMC inogona kuumba yunifomu yetiweki chimiro mumvura kuburikidza nemhinduro yayo thickening uye hydrophilic mapoka mune yayo molecular chimiro, kuputira akapararira zvimedu kudzivirira particle agglomeration, sedimentation kana stratification, nokudaro zvichivandudza kugadzikana kweiyo yakapararira system. Izvi zvinonyanya kukosha kune zvigadzirwa senge emulsions, suspensions, uye coatings.
Firimu-kuumba zvivakwa uye inodzivirira layer mhedzisiro
Iyo firimu-inogadzira zvimiro zveHPMC inoita kuti iite yunifomu firimu pamusoro pechigadzirwa mushure mekuoma. Iyi firimu haingodzivise zvinhu zvinoshanda muchigadzirwa kubva pakuva oxidized kana kusvibiswa nenyika yekunze, asi inogonawo kushandiswa muminda yemishonga uye chikafu kudzora chiyero chekuburitswa kwezvinodhaka kana kuwedzera sherufu yehupenyu hwekudya. Pamusoro pezvo, iyo inodzivirira yakaumbwa neHPMC inogona zvakare kudzivirira kurasikirwa kwemvura uye kuvandudza kusimba mune zvekuvaka senge simende dhaka uye machira.
Thermal kugadzikana uye tembiricha inopindura
HPMC inoratidza kugadzikana kwakanaka pane tembiricha dzakasiyana. Viscosity yaro mumushonga wemvura inonyanya kunzwisiswa nekuchinja kwekushisa, asi mhinduro viscosity inoramba ichingogara pamhepo tembiricha. Pamusoro pezvo, HPMC inopinda gelation inodzoreredzwa pane imwe tembiricha, izvo zvinoita kuti ive neyakagadzika yekudzikamisa maitiro mumasisitimu anoda kuve anonzwisisa tembiricha (sekudya uye mushonga).
3. Kushandiswa kweHPMC kuvandudza kugadzikana mune dzakasiyana siyana
Kushandiswa muzvinhu zvekuvaka
Muzvivakwa zvekuvaka senge simende dhaka uye mataira adhesive, HPMC inowanzoshandiswa kugadzirisa kuenderana kweiyo slurry uye kuwedzera fluidity uye kushanda panguva yekuvaka. Mukuwedzera, HPMC inonyatso kunonoka kubuda kwemvura nekugadzira firimu mushure mekuoma, kudzivisa kuputika kana kupfupisa nguva yekushanda panguva yekuvaka, nokudaro kuvandudza kugadzikana kwezvinhu uye unhu hwekuvaka.
Kushandiswa mukugadzirira kwemishonga
Mukugadzirira kwemishonga, HPMC inoshandiswa zvakanyanya seyakakora, firimu rekare uye rinodzorwa kuburitsa mumiriri. Iko kukora kwekuita kwayo kunogona kuvandudza kugadzikana kwezvinhu zvinoshanda mukumiswa kana emulsions uye kudzivirira stratification yezvinodhaka kana kunaya. Pamusoro pezvo, iyo firimu inodzivirira yakaumbwa neHPMC inogona kudzora kuburitswa kwezvinodhaka uye kuwedzera nguva yekushanda kwezvinodhaka. Kunyanya mukugadzirira-kuburitswa-kuburitswa, HPMC ndeimwe yeakajairika excipient.
Kushandisa muzvokudya
Muindasitiri yechikafu, HPMC inonyanya kushandiswa seyakakora uye emulsifier kuvandudza magadzirirwo uye kuravira kwechikafu. Iyo yakanakisa hydration kugona inogona kuchengetedza unyoro uye kuwedzera hupenyu hwesherufu hwezvigadzirwa. Semuyenzaniso, muzvinhu zvakabikwa, HPMC inogona kudzivirira mvura kuti isanyunguke nekukasira uye kunatsiridza fluffiness uye kupfava kwechingwa nemakeke. Uye zvakare, iyo firimu-yekugadzira pfuma yeHPMC inogona zvakare kushandiswa kupfekedza chikafu kudzivirira oxidation uye kuora.
Kushandiswa mune zvigadzirwa zvemakemikari zvemazuva ese
Muzvigadzirwa zvemazuva ese zvemakemikari senge dhizaini, shampoos, uye zvigadzirwa zvekuchengetedza ganda, HPMC inowanzoshandiswa seyakakora uye kudzikamisa. Inogona kuwedzera kuwirirana kwechigadzirwa, kuvandudza kufanana kwechimiro, kuita kuti emulsions kana gel zvigadzirwa zvive nyore kushandisa uye zvishoma zvingaita stratify kana precipitate. Panguva imwecheteyo, iyo moisturizing mhedzisiro yeHPMC inobatsirawo kuvandudza iyo moisturizing maitiro ezvigadzirwa zvekuchengetedza ganda.
Seyakakosha cellulose ether derivative, HPMC inoshandiswa zvakanyanya mumaindasitiri akasiyana nekuda kwekukora kwayo, kugadzira firimu, kumiswa uye kugadzikana kwekupisa, kunyanya mukuvandudza kugadzikana kwechigadzirwa. Zvingave mune zvekuvakisa, mushonga, chikafu kana zvigadzirwa zvemazuva ese zvemakemikari, HPMC inogona kuwedzera zvakanyanya hupenyu hwesevhisi yechigadzirwa uye kuvandudza mashandiro ayo kuburikidza nenzira dzakasiyana siyana sekusimudzira viscosity yehurongwa, kugadzirisa rheological properties, kuvandudza kumiswa uye kupararira kugadzikana, uye kugadzira firimu rinodzivirira. Mune ramangwana, nekufambira mberi kwetekinoroji uye nekuenderera mberi kwekuwedzera kwendima dzekushandisa, kugona kwekushandisa kweHPMC mune mamwe minda kucharatidzwa zvakare.
Nguva yekutumira: Sep-21-2024