Hydroxypropyl Methylcellulose (HPMC) yakakosha cellulose ether derivative yakashandiswa zvakanyanya muminda yakawanda yemaindasitiri nekuda kwekusiyana kwayo kwemuviri nemakemikari. Yayo viscosity zvimiro ndechimwe chezvinhu zvakakosha zveHPMC, inokanganisa zvakananga kuita kwayo mumashandisirwo akasiyana siyana.
1. Zvinhu zvakakosha zveHPMC
HPMC is nonionic cellulose ether inowanikwa nekutsiva chikamu chemapoka ehydroxyl (-OH) mumorekuru we cellulose nemapoka methoxy (-OCH3) uye hydroxypropyl mapoka (–OCH2CH(OH) CH3). Iyo ine yakanaka solubility mumvura uye zvimwe organic zvinonyungudutsa, zvichigadzira transparent colloidal mhinduro. Iyo viscosity yeHPMC inonyanya kutsanangurwa nehuremu hwayo hwemamorekuru, dhigirii rekutsiva (DS, Dhigirii reKutsiva) uye inotsiva kugovera.
2. Kutsunga kwe viscosity yeHPMC
Iyo viscosity yeHPMC mhinduro inowanzoyerwa pachishandiswa rotational viscometer kana capillary viscometer. Pakuyera, kutarisisa kunoda kubhadharwa kune kusungwa, tembiricha uye shear mwero wemhinduro, sezvo izvi zvinhu zvinogona kukanganisa zvakanyanya kukosha kweviscosity.
Solution concentration: Iyo viscosity yeHPMC inowedzera nekuwedzera kwekugadziriswa kwemhinduro. Kana iyo yekusangana kweHPMC mhinduro yakadzikira, kudyidzana pakati pemamorekuru kwakaderera uye viscosity yakaderera. Sezvo kusungirirwa kunowedzera, kusungirirwa uye kupindirana pakati pemamorekuru kunowedzera, zvichikonzera kuwedzera kukuru kwe viscosity.
Tembiricha: Iyo viscosity yeHPMC mhinduro inonzwa zvakanyanya kune tembiricha. Kazhinji, sezvo tembiricha inowedzera, viscosity yeHPMC mhinduro inoderera. Izvi zvinokonzerwa nekuwedzera tembiricha inotungamira kukuwedzera kwema molecular kufamba uye kuderera kwekudyidzana kweintermolecular. Zvinofanira kucherechedzwa kuti HPMC pamwe siyana madhigirii yokutsiva uye molecular uremu vane zvakasiyana kunzwa tembiricha.
Shear rate: HPMC solutions inoratidza pseudoplastic (shear thinning) maitiro, kureva kuti viscosity yakakwira pamutengo wakaderera wekugera uye inodzikira pamazinga akakwira ekugera. Maitiro aya anokonzerwa nemasimba ekugera anoenzanisa macheni emamorekuru padivi penzira yekugera, nekudaro kuderedza kusungirirwa uye kudyidzana pakati pemamorekuru.
3. Zvinhu zvinokanganisa HPMC viscosity
Molecular uremu: Huremu hwemamorekuru eHPMC ndechimwe chezvinhu zvakakosha zvinotaridza viscosity yayo. Kazhinji kutaura, kukura kwehuremu hwema molecular, kunowedzera viscosity yemhinduro. Izvi zvinodaro nekuti HPMC mamorekuru ane huremu hwemamorekuru anowanzo kuumba network dzakabatikana, nekudaro achiwedzera kukweshera kwemukati kwemhinduro.
Dhigirii yekutsiva uye inotsiva kugovera: Nhamba uye kugovera kwemethoxy uye hydroxypropyl zvinotsiva muHPMC zvinokanganisawo viscosity yayo. Kazhinji, iyo yakakwirira dhigirii yemethoxy substitution (DS), iyo inodzika iyo viscosity yeHPMC, nekuti kuiswa kwemethoxy substituents kunoderedza iyo hydrogen bonding simba pakati pemamorekuru. Iko kuiswa kwe hydroxypropyl substituents kuchawedzera intermolecular kupindirana, nekudaro kuwedzera viscosity. Mukuwedzera, kugoverwa kweyunifomu yezvinotsiva kunobatsira kuumba yakagadzikana yekugadzirisa hurongwa uye kuwedzera viscosity yemhinduro.
pH kukosha kwemushonga: Kunyangwe HPMC isiri-ionic polymer uye viscosity yayo haina hanya nekuchinja kwepH kukosha kwemhinduro, yakanyanyisa pH kukosha (yakanyanya acidic kana yakanyanya alkaline) inogona kukonzera kuderera kweiyo molecular chimiro. HPMC, nokudaro inokanganisa viscosity.
4. Nzvimbo dzekushandisa dzeHPMC
Nekuda kweakanakisa viscosity maitiro, HPMC inoshandiswa zvakanyanya muminda yakawanda:
Zvishandiso zvekuvakisa: Muzvivakwa zvekuvaka, HPMC inoshandiswa seyakakora uye inochengetedza mvura mumiriri kunatsiridza kuita kwekuvaka uye kuwedzera kutsemuka kuramba.
Indasitiri yemishonga: Muindasitiri yemishonga, HPMC inoshandiswa sebhainda remapiritsi, mumiriri wekugadzira firimu remakapisi uye mutakuri wemishonga inoburitswa.
Indasitiri yechikafu: HPMC inoshandiswa seyakakora uye inodzikamisa muindasitiri yechikafu kugadzira ice cream, jelly uye zvigadzirwa zvemukaka.
Zvigadzirwa zvemakemikari zvemazuva ese: Muzvigadzirwa zvemakemikari zvemazuva ese, HPMC inoshandiswa seyakakora uye inodzikamisa kugadzirwa kwe shampoo, gel yekugeza, mushonga wemazino, nezvimwe.
Iyo viscosity maitiro eHPMC ndiyo hwaro hwekuita kwayo kwakanakisa mumashandisirwo akasiyana siyana. Nekudzora huremu hwemamorekuru, dhigirii rekutsiva, uye mhinduro mamiriro eHPMC, viscosity yayo inogona kugadziridzwa kuti isangane nezvinodiwa zvakasiyana zvekushandisa. Mune ramangwana, kutsvagisa kwakadzama pahukama pakati peHPMC molecular chimiro uye viscosity kuchabatsira kugadzira zvigadzirwa zveHPMC nekuita zvirinani uye kuwedzera minda yayo yekushandisa.
Nguva yekutumira: Jul-20-2024