Hypromellose, inozivikanwawo se hydroxypropyl methylcellulose (HPMC), inogoneka semi-synthetic polymer inotorwa kubva ku cellulose. Nekuda kweiyo yakasarudzika makemikari uye emuviri zvimiro, HPMC inowanzoshandiswa seyakakora, stabilizer uye inonamira mumishonga yemishonga, chikafu uye yekuchengeta maindasitiri. Muchikamu chino, tinokurukura chemistry yeHPMCs uye mashandisirwo azvo akakosha.
1. Solubility
Imwe yeanonyanya kukosha emakemikari zvimiro zveHPMC ndiko kunyungudika kwayo. HPMC inonyungudika mumvura uye akawanda organic zvinonyungudutsa, zvichiita kuti ive chinhu chakakodzera chekushandisa zvinodhaka masisitimu uye mamwe maapplication anoda kuparadzwa. Nekudaro, kunyungudika kweHPMC kunotemerwa zvakanyanya nedhigirii rayo rekutsiva (DS), iyo inotaridza huwandu hwehydroxypropyl uye methyl mapoka aripo mu polymer cheni. HPMCs ine yakakwira DS ine yakaderera solubility nekuda kwekuwedzera intermolecular kudyidzana.
2. Rheology
Imwe yakakosha kemikari pfuma yeHPMC maitiro ayo rheological. Kugona kweHPMC kugadzira gel-senetiweki pane hydration inogona kushandiswa kudzora viscosity uye kuyerera maitiro ekugadzira. HPMC inoratidzawo isiri-Newtonian kuyerera maitiro, zvichireva kuti viscosity yayo inoshanduka zvichienderana neyakaiswa shear rate. Ichi chivakwa chinogona kudzorwazve nekugadzirisa kusungwa kweHPMC uye DS mukugadzira.
3. Kuumbwa kwemafirimu
HPMC inoshandiswa zvakanyanya seyaimbova firimu nekuda kwekugona kwayo kuumba mayunifomu mafirimu kana akaiswa kune substrate. Iyo firimu-inogadzira zvimiro zveHPMC zvinoenderana neDS yayo, viscosity uye kuvapo kweplasticizers, iyo inogona kuvandudza elasticity uye kuchinjika kwefirimu. Mafirimu akagadzirwa kubva kuHPMC anowanzo shandiswa mukuendesa zvinodhaka nekuti anotendera kuburitswa kwakadzorwa kwezvinhu zvinoshanda.
4. Kugarisana
HPMC inonyatso enderana excipient uye inogona kushandiswa zvakasiyana-siyana maumbirwo. Inopindirana nemishonga yakawanda yemishonga, kusanganisira inoshanda yemishonga yemishonga (APIs) uye zvimwe zvinobatsira zvinowanzoshandiswa mukugadzirwa kwemishonga. HPMC inopindiranawo nezvakawanda zvekudya zvinongedzo, zvichiita kuti ive sarudzo yakakurumbira yekushandisa chikafu.
5. Kugadzikana kwemakemikari
HPMC ipolyme yakagadzikana inopikisa hydrolysis uye mamwe maitiro emakemikari. Kugadzikana uku kunoita kuti ive chinhu chakakodzera chekushandisa zvinodhaka masisitimu sezvo ichidzivirira iyo inoshanda musanganiswa kubva mukuora uye inowedzera bioavailability yayo. Nekudaro, kugadzikana kwemakemikari eHPMC kunogona kukanganiswa nekupisa kwakanyanya, humidity yakakwira, uye zvimwe zvinonyungudutsa, izvo zvinogona kukonzera iyo polymer kudzikisira uye kuderedza kushanda kwayo mukuumbwa.
6. Biocompatibility
Chekupedzisira, HPMC inonyatso biocompatible polymer iyo yakachengeteka kushandiswa mumishonga uye zvigadzirwa zvekuchengeta munhu. Iyo isiri-chepfu, isiri-immunogenic uye biodegradable, ichiita kuti ive yakanaka kune maumbirwo anoda kushoma muchetura uye yakanyanya kuchengetedzeka.
Muchidimbu, HPMC hypromellose ipolymer inoshanda yakawanda ine huwandu hwezvinhu zvakakosha zvemakemikari, kusanganisira solubility, rheology, firimu-kugadzira zvinhu, kuenderana, kugadzikana kwemakemikari, uye biocompatibility. Izvi zvivakwa zvinoita kuti ive yakanakira mukana wekushandisa zvinodhaka masisitimu uye zvimwe zvinoshandiswa mumaindasitiri ezvekudya uye ega ega. Sezvo tsvagiridzo ichienderera mberi nekuwedzera manzwisisiro edu eHPMCs, yavo yakasarudzika zvivakwa inogona kuwana yakakura mashandisiro mune ramangwana.
Nguva yekutumira: Jul-28-2023