Hydroxypropyl Methylcellulose (HPMC) i polymer inoshanda zvakasiyana-siyana inoshandiswa mumaindasitiri akasiyana siyana anosanganisira mishonga, kuvaka, chikafu, uye zvekuzora.Inotorwa kubva ku cellulose, yakasikwa polymer inowanikwa mumiti.HPMC inofarirwa zvakanyanya nekuda kwekugadzira firimu, kukora, kudzikamisa, uye kuchengetedza mvura.Muindasitiri yemishonga, inowanzo shandiswa semubatsiri wemishonga mumuromo mafomu emushonga, gadziriro dzemaziso, maumbirwo epamusoro, uye masystem anodzorwa-anoburitsa zvinodhaka.
HPMC inogona kuverengerwa zvichibva pane akati wandei ma paramita anosanganisira ayo mamorekuru huremu, dhigirii rekutsiva, uye saizi yechikamu.Heino tarisiro yemhando dzakasiyana dzeHPMC zvichibva pane aya paramita:
Kubva pane Molecular Weight:
Yakakwira Molecular Weight HPMC: Rudzi urwu rweHPMC ine huremu hwepamusoro hwemamorekuru, zvinotungamira kune yakawedzera viscosity uye firimu-kugadzira zvivakwa.Inowanzo kufarirwa mumashandisirwo apo yakakwirira viscosity inodiwa, senge mune inodzorwa-kuburitswa maumbirwo.
Low Molecular Weight HPMC: Zvikasadaro, yakaderera molecular uremu HPMC ine yakaderera viscosity uye inoshandiswa muzvishandiso uko yakaderera viscosity uye nekukurumidza kunyungudika kunodiwa.
Kubva pane Dhigirii reKutsiva (DS):
High Substitution HPMC (HPMC-HS): HPMC ine dhigirii yakakwira yekutsiva kazhinji inoratidza kunyungudika kuri nani mumvura uye inogona kushandiswa mumiumbirwo inoda kukurumidza kunyungudika.
Medium Substitution HPMC (HPMC-MS): Iyi mhando yeHPMC inopa chiyero pakati pekunyungudika uye viscosity.Inowanzoshandiswa mumishonga yakasiyana-siyana yemishonga.
Low Substitution HPMC (HPMC-LS): HPMC ine dhigirii yakaderera yekutsiva inopa inononoka kunyungudika mazinga uye yakakwirira viscosity.Inowanzo shandiswa mune inoenderera-kuburitsa dosage mafomu.
Kubva pane Particle Size:
Yakanaka Particle Size HPMC: HPMC ine diki diki saizi inopa zvirinani kuyerera zvivakwa uye inowanzofarirwa mune yakasimba dosage mafomu senge mahwendefa nemakapisi.
Coarse Particle Size HPMC: Coarser zvimedu zvakakodzerwa nekushandisa uko kunodzorwa kuburitswa kana kurebesa-kuburitsa zvivakwa kunodiwa.Ivo vanowanzoshandiswa mumatrix mahwendefa uye pellets.
Specialty Grades:
Enteric HPMC: Rudzi urwu rweHPMC rwakanyatsogadzirirwa kudzivirira gastric fluid, ichiita kuti ipfuure nemudumbu isina kusimba uye kuburitsa mushonga muura.Inowanzo shandiswa kumishonga inobata gastric pH kana kune yakanangwa kuendesa.
Sustained Release HPMC: Aya magadzirirwo akagadzirirwa kuburitsa iyo inoshanda musanganiswa zvishoma nezvishoma pamusoro penguva yakawedzerwa, zvichitungamira mukurebesa kuita kwezvinodhaka uye kuderedzwa dosing frequency.Iwo anowanzo shandiswa mumamiriro asingaperi apo kuchengetedza nguva dzose mazinga emishonga muropa kwakakosha.
Combination Grades:
HPMC-Acetate Succinate (HPMC-AS): Iyi mhando yeHPMC inobatanidza zvinhu zveHPMC nemapoka e-acetyl, zvichiita kuti zvive zvakakodzera kune enteric coatings uye pH-sensitive drug delivery systems.
HPMC-Phthalate (HPMC-P): HPMC-P iph-inotsamira polima inowanzoshandiswa muenteric coatings kudzivirira mushonga kubva kune acidic mamiriro mudumbu.
Customized Blends:
Vagadziri vanogona kugadzira masanganiswa akajairwa eHPMC nemamwe mapolymer kana maexcipients kuti awane zvakanangana magadzirirwo anodikanwa senge akagadziridzwa maprofile ekuburitsa zvinodhaka, kusimba kwakawedzera, kana zvirinani kuravira-kumisa zvivakwa.
zvinhu zvakasiyana-siyana zveHPMC zvinobvumira kushandiswa kwayo mune zvakasiyana-siyana zvekugadzirwa kwemishonga, imwe neimwe yakarongedzerwa kusangana nezvinodiwa zvakadai sekunyungudika, viscosity, kusunungurwa kinetics, uye kugadzikana.Kunzwisisa marudzi akasiyana eHPMC nehunhu hwawo kwakakosha kuti vagadziri vagadzire masisitimu ekupa zvinodhaka anoshanda uye akakwenenzverwa.
Nguva yekutumira: Mar-19-2024