Hydroxypropyl methylcellulose (HPMC) inowanzoshandiswa polima mumishonga, zvizorwa, zvigadzirwa zvekudya, uye mamwe akasiyana maindasitiri ekushandisa. Iyo inoshandiswa zvakanyanya nekuda kweiyo biocompatibility, isiri-chepfu, uye kugona kugadzirisa iyo rheological zvimiro zvemhinduro. Nekudaro, zvakakosha kuti unzwisise nzira yekunyungudutsa HPMC nemazvo kushandisa zvivakwa zvayo nemazvo.
Mvura: HPMC inonyungudika zvakanyanya mumvura, zvichiita kuti ive sarudzo yakasarudzika kune akawanda maapplication. Nekudaro, mwero wekuparara unogona kusiyana zvichienderana nezvinhu zvakaita setembiricha, pH, uye giredhi reHPMC rinoshandiswa.
Organic Solvents: Yakasiyana organic solvents inogona kunyungudutsa HPMC kune akasiyana siyana. Zvimwe zvakajairika organic solvents zvinosanganisira:
Doro: Isopropanol (IPA), ethanol, methanol, etc. Izvi zvinodhaka zvinowanzoshandiswa mukugadzirwa kwemishonga uye zvinogona kunyatsopedza HPMC.
Acetone: Acetone inonyungudutsa yakasimba inogona kunyungudutsa HPMC zvakanaka.
Ethyl Acetate: Ndiyo imwe organic solvent inogona kunyungudutsa HPMC zvinobudirira.
Chloroform: Chloroform inonyungudutsa ine hukasha uye inofanira kushandiswa nekuchenjerera nekuda kwehuturu hwayo.
Dimethyl Sulfoxide (DMSO): DMSO is polar aprotic solvent inogona kunyungudutsa zvakasiyana-siyana zvemakemikari, kusanganisira HPMC.
Propylene Glycol (PG): PG inowanzoshandiswa seco-solvent mukugadzirwa kwemishonga. Inogona kunyungudutsa HPMC zvinobudirira uye inowanzoshandiswa pamwe chete nemvura kana zvimwe zvinonyungudutsa.
Glycerin: Glycerin, inozivikanwawo se glycerol, inonyungudutsa yakajairika mumishonga uye zvizoro. Inowanzoshandiswa pamwe chete nemvura kuti iparadze HPMC.
Polyethylene Glycol (PEG): PEG ipolymer ine yakanakisa solubility mumvura uye akawanda organic solvents. Inogona kushandiswa kunyungudutsa HPMC uye inowanzo shandiswa mukusimudzira-kuburitswa mafomu.
Masurfactants: Mamwe ma surfactants anogona kubatsira mukuparara kweHPMC nekudzikisa kushushikana kwepasi nekuvandudza weti. Mienzaniso inosanganisira Pakati pe80, sodium lauryl sulfate (SLS), uye polysorbate 80.
Yakasimba Asidhi kana Mabhesi: Kunyange isingawanzo shandiswa nekuda kwekunetseka kwekuchengetedza uye kukanganisa kunogona kuitika kweHPMC, asidhi yakasimba (semuenzaniso, hydrochloric acid) kana mabhesi (semuenzaniso, sodium hydroxide) inogona kunyungudutsa HPMC pasi pemamiriro akakodzera. Nekudaro, yakanyanyisa pH mamiriro anogona kutungamira mukuderedzwa kwepolymer.
Complexing Agents: Mamwe maajenti akaomarara senge cyclodextrins anogona kuumba inclusion complexes neHPMC, achibatsira mukuparara kwayo uye kuwedzera kunyungudika kwayo.
Tembiricha: Kazhinji, tembiricha yepamusoro inosimudzira chiyero chekunyungudika cheHPMC mune zvinonyungudutsa semvura. Nekudaro, tembiricha yakakwira zvakanyanya inogona kukanganisa iyo polymer, saka zvakakosha kuti ushande mukati metembiricha yakachengeteka.
Mechanical Agitation: Kukurudzira kana kusanganisa kunogona kufambisa kuparara kweHPMC nekuwedzera kubatana pakati pepolymer uye solvent.
Particle Size: Finely powdered HPMC ichanyunguduka zviri nyore kupfuura zvidimbu zvakakura nekuda kwekuwedzera kwenzvimbo.
Izvo zvakakosha kuti uzive kuti sarudzo yezvinonyungudutsa uye kunyungudutswa mamiriro zvinoenderana neiyo chaiyo mashandisirwo uye inodiwa zvimiro zvechigadzirwa chekupedzisira. Kuenderana nezvimwe zvinongedzo, kufunga nezvekuchengetedza, uye zvinodikanwa zvekutonga zvakare zvinopesvedzera kusarudzwa kwezvinonyungudutsa uye nzira dzekunyungudutsa. Pamusoro pezvo, zvakakosha kuita zvidzidzo zvekuenderana uye kuyedzwa kwekugadzikana kuti ive nechokwadi chekuti nzira yekumisa haina kukanganisa kunaka kana kuita kwechigadzirwa chekupedzisira.
Nguva yekutumira: Mar-22-2024