suma:
Hydroxypropylmethylcellulose (HPMC) ipolymer inonyungudika nemvura inowanzoshandiswa mumaindasitiri akasiyana siyana uye mishonga yemishonga nekuda kwekunaka kwayo kuumba firimu, kusunga uye kukora zvivakwa. Pakati pezvakawanda zvekushandisa, HPMC inoshandiswa zvakanyanya muindasitiri yekuvaka nekuda kwekugona kwayo kuchengetedza mvura.
Kuchengetedzwa kwemvura chinhu chakakosha chinotaridza kushanda kwezvinhu zvekuvaka sedhaka, simende uye kongiri. Kana HPMC ichiwedzerwa kune izvi zvinhu, inogona kuwedzera zvakanyanya simba ravo rekuchengetedza mvura, zvichikonzera zvirinani processability, kuderedzwa shrinkage uye kuwedzera simba.
Nekudaro, zvinhu zvakati wandei zvinogona kukanganisa mvura yekuchengetedza zvivakwa zveHPMC. Ichi chinyorwa chinoongorora zvinhu izvi uye maitiro azvo pakuchengetedza mvura kweHPMC.
Zvinhu zvinokanganisa kuchengetwa kwemvura kweHPMC:
1. Huremu hweMolecular:
Huremu hwemamorekuru hweHPMC hunokanganisa zvakanyanya zvimiro zvayo zvekuchengetedza mvura. Yepamusoro mamorekuru huremu HPMCs kazhinji anoratidza zvirinani kuchengetedza kwemvura nekuda kwekukora kwawo zvivakwa.
Huremu hwemamorekuru eHPMC hunogona kudzorwa panguva yekugadzira, uye vagadziri vanogona kuburitsa mamakisi akasiyana eHPMC ane akasiyana mamorekuru maremu kuti asangane nezvinodiwa zvekushandisa.
2. Tembiricha:
Tembiricha ndechimwe chinhu chakakosha chinokanganisa simba rekuchengetedza mvura reHPMC. Pakudziya kwakadzika, simba rekuchengetedza mvura reHPMC rinodzikira, zvichikonzera kusashanda zvakanaka uye kuwedzera kuderera.
Kune rimwe divi, HPMC inoratidza kuchengetedzwa kwemvura kuri nani pakupisa kwakanyanya, zvichiita kuti ive yakakodzera kushandiswa munzvimbo dzinodziya uye muzhizha.
3. pH:
Iyo pH kukosha kwenzvimbo iyo HPMC inoshandiswa ichakanganisawo simba rekuchengetedza mvura. HPMC inoratidza kuchengetedzwa kwemvura kuri nani munzvimbo dzisina kwazvakarerekera kana zvishoma alkaline pH nharaunda.
Munzvimbo ine acidic, simba rekuchengetedza mvura reHPMC rinodzikira, zvichikonzera kusavakwa zvakanaka uye kuwedzera kuderera kwezvinhu zvekuvakisa.
4. Dosage:
Huwandu hweHPMC hwakawedzerwa kune chivakwa chekuvaka hunogona kukanganisa zvakanyanya simba rekuchengetedza mvura. Iyo yakakwana huwandu hweHPMC hunoenderana neiyo chaiyo application uye zvimwe zvezvinhu zvinhu.
Yakawandisa HPMC inozokonzera kuwedzera viscosity, kuderedzwa processability uye kuwedzera shrinkage. Kune rumwe rutivi, kusakwana kwehuwandu hweHPMC kunotungamirira kukuchengetedza kusina kunaka kwemvura, izvo zvinotungamirira kuderera kwesimba uye kuwedzera kwekuputika.
5. Nguva yekufambisa:
Iyo yekusanganisa nguva yeHPMC nezvinhu zvekuvaka inokanganisawo kugona kwayo kuchengetedza mvura. Yakakwana nguva yekusanganisa inogona kuita kuti yunifomu yekupararira kweHPMC zvimedu uye nani kuchengetedza mvura.
Kusakwana kusanganisa nguva kunogona kutungamira kune kushomeka kwechikamu chekugovera kweHPMC, izvo zvinogona kutungamira mukuderedzwa kwekuchengetedza mvura uye dzimwe nyaya dzekuita.
6. Rudzi rwezvinhu zvekuvaka:
Mhando yezvinhu zvekuvaka inoshandiswa muHPMC inokanganisawo kugona kwayo kubata mvura. Zvishandiso zvakasiyana zvinoda mazinga akasiyana ekuchengetedza mvura, uye HPMC inogona kugadzirwa kuti isangane nezvimwe zvinhu zvinodiwa.
Semuenzaniso, dhaka rinoda simba rekuchengetedza mvura yakawanda, nepo kongiri inoda huwandu hwekuchengetedza mvura. Naizvozvo, mamakisi akasiyana eHPMC akagadzirirwa akasiyana ekuvaka.
mukupedzisa:
Muchidimbu, kuchengetwa kwemvura inzvimbo yakakosha inosarudza kushanda kwezvinhu zvekuvaka. HPMC inzvimbo yakanakisa yekuchengetedza mvura, iyo inogona kuwedzera simba rekuchengetedza mvura simende, dhaka, kongiri uye zvimwe zvekuvaka.
Nekudaro, zvinhu zvakasiyana-siyana, senge mamorekuru huremu, tembiricha, pH, dosi, nguva yekusanganisa, uye rudzi rwezvinhu zvekuvaka zvinoshandiswa muHPMC, zvinogona kukanganisa zvimiro zvayo zvekuchengetedza mvura.
Vagadziri vanofanirwa kufunga nezvezvinhu izvi uye kugadzirisa zvivakwa uye huwandu hweHPMC kune chaiyo yekuvaka zvikumbiro kuti vawane yakakwana yekuchengetedza mvura uye mamwe mabhenefiti ekuita.
Nguva yekutumira: Aug-08-2023