Hydroxypropyl methylcellulose (HPMC) inogoneka uye inoshandiswa zvakanyanya polymer mumaindasitiri akasiyana, inozivikanwa neyakasiyana zvivakwa uye mashandisirwo. Mushonga uyu unobva ku cellulose, polima yemusikirwo inowanikwa mumadziro esero rezvirimwa. Kuti unzwisise kuumbwa kwehydroxypropylmethylcellulose, zvinodikanwa kuti utarise muchimiro uye kuumbwa kweiyi cellulose derivative.
Chimiro che cellulose:
Cellulose i-carbohydrate yakaoma inosanganisira mutsara weketani ye-β-D-glucose units yakabatanidzwa ne-β-1,4-glycosidic bonds. Aya macheni eglucose anobatwa pamwechete nehydrogen zvisungo kuti aumbe mutsara wakaomarara chimiro. Cellulose ndiyo inonyanya kuumbwa chikamu chechirimwa masero madziro, ichipa simba uye kusimba kune kudyara maseru.
Zvinyorwa zveHydroxypropyl Methylcellulose:
Hydroxypropyl methylcellulose inogadzirwa nekemikari inoshandura cellulose uye kuunza hydroxypropyl uye methyl mapoka muketani huru ye cellulose. Kugadzirwa kazhinji kunosanganisira matanho anotevera:
Etherification reaction:
Methylation: Kurapa cellulose ine alkaline solution uye methyl chloride kuunza methyl mapoka (-CH3) mumapoka ehydroxyl (-OH) e cellulose.
Hydroxypropylation: Methylated cellulose inowedzera kuita nepropylene oxide kuunza hydroxypropyl mapoka (-CH2CHOHCH3) muchimiro che cellulose. Iyi nzira inowedzera kunyungudika kwemvura uye inoshandura chimiro chemuviri we cellulose.
kucheneswa:
Iyo yakagadziridzwa cellulose inobva yacheneswa kuti ibvise chero isina kubatwa reagents, ne-zvigadzirwa kana tsvina.
Kuomesa nekukuya:
Iyo yakacheneswa hydroxypropyl methylcellulose inoomeswa uye inogayiwa kuita hupfu hwakatsetseka hwakagadzirira kushandiswa mune dzakasiyana siyana.
Zvinoumba Hydroxypropyl Methylcellulose:
Iko kuumbwa kwehydroxypropyl methylcellulose kunoratidzwa nedhigirii rekutsiviwa, izvo zvinoreva dhigirii iro hydroxypropyl uye methyl mapoka anotsiva mapoka ehydroxyl mucheni ye cellulose. Akasiyana mamakisi eHPMC ane madhigirii akasiyana ekutsiva, anokanganisa kunyungudika kwavo, viscosity uye zvimwe zvivakwa.
Mushonga wekemikari wehydroxypropyl methylcellulose unogona kuratidzwa se (C6H7O2(OH)3-mn(OCH3)m(OCH2CH(OH)CH3)n)_x,apo m uye n inomiririra dhigirii rekutsiva.
m: dhigirii remethylation (methyl mapoka paglucose unit)
n: dhigirii rehydroxypropylation (hydroxypropyl mapoka paglucose unit)
x: nhamba yemayuniti eglucose mucheni ye cellulose
Features uye Applications:
Solubility: HPMC inonyungudika mumvura, uye dhigirii rekutsiva rinokanganisa hunhu hwayo hwekunyungudika. Inoumba mhinduro yakajeka uye yakasvibiswa mumvura, ichiita kuti ive yakakodzera kune zvakasiyana-siyana zvekugadzirisa.
Viscosity: Iyo viscosity yeHPMC mhinduro inoenderana nezvinhu zvakaita semamorekuru huremu uye dhigirii rekutsiva. Ichi chivakwa chakakosha kune zvikumbiro zvakaita semishonga inoda kudzorwa kuburitsa maumbirwo.
Kugadzira Firimu: HPMC inogona kugadzira mafirimu matete sezvo mhinduro ichioma, ichiita kuti ibatsire mukuputira mumishonga, chikafu uye mamwe maindasitiri.
Stabilizers uye Thickeners: Muindasitiri yechikafu, HPMC inoshandiswa seyakakora uye inodzikamisa mune zvakasiyana zvigadzirwa, zvinosanganisira sosi, madhiri, uye zvakabikwa zvinhu.
Pharmaceutical Applications: HPMC inoshandiswa zvakanyanya mukugadzirwa kwemishonga, kusanganisira mahwendefa, capsules, uye ophthalmic mhinduro, nekuda kwekutonga kwayo kuburitsa zvinhu uye biocompatibility.
Kuvaka uye machira: HPMC inoshandiswa mukuvaka zvinhu senge madhaka, mataira anonamira uye plasters. Iyo inoshandiswa zvakare seyakakora uye inodzikamisa mupende uye yekuputira maumbirwo.
Zvigadzirwa Zvekuchengeta Pamunhu: Muindasitiri yezvizoro uye yekuchengeta munhu, HPMC inowanikwa mune zvigadzirwa zvakaita semafuta, lotions uye shampoos, kwainopa magadzirirwo uye kugadzikana.
Hydroxypropyl methylcellulose inowanikwa nemethylation uye hydroxypropylation ye cellulose. Iyo yakawanda-chinangwa polymer ine huwandu hwakawanda hwekushandisa. Hunhu hwayo hwakasiyana hunoita kuti ive yakakosha mumaindasitiri akadai semishonga, chikafu, kuvaka uye kuzvitarisira. Kudzorwa kugadziridzwa kweselulosi kunogona kukwenenzvera zvivakwa zveHPMC, zvichiita kuti ive chinhu chakakosha chezvakawanda zvigadzirwa zvatinosangana nazvo muhupenyu hwedu hwezuva nezuva.
Nguva yekutumira: Jan-10-2024