Hydroxypropylmethylcellulose (HPMC) uye carboxymethylcellulose (CMC) marudzi maviri akasiyana emapolymers anoshandiswa mukudonha kwemaziso, anowanzo shandiswa kubvisa zviratidzo zvemaziso akaoma. Kunyangwe vachigovana zvimwe zvakafanana, maviri aya makomisheni ane mutsauko wakajeka muchimiro chavo chemakemikari, zvivakwa, mashandiro echiito, uye makiriniki ekushandisa.
Hydroxypropyl methylcellulose (HPMC) madonhwe eziso:
1.Chemical chimiro:
HPMC inogadzirwa kubva kune cellulose, yakasikwa polymer inowanikwa muchirimwa sero madziro.
Hydroxypropyl uye methyl mapoka anounzwa mune cellulose chimiro, ichipa HPMC yakasarudzika zvivakwa.
2. Viscosity uye rheology:
HPMC madonhwe eziso kazhinji ane viscosity yepamusoro kupfuura mamwe akawanda anozora madonhwe eziso.
Iyo yakawedzera viscosity inobatsira madonhwe kuramba ari pameso epamusoro kwenguva refu, achipa zororo renguva refu.
3. Nzira yekuita:
HPMC inoumba chidziviriro uye chekuzora pamusoro pemeso, kuderedza kukweshera uye kugadzirisa kubvarura firimu kugadzikana.
Inobatsira kudzikisira zviratidzo zvemaziso akaoma nekudzivirira kubuda kwakanyanya kwemisodzi.
4. Clinical application:
HPMC ziso madonhwe anowanzoshandiswa kurapa yakaoma eye syndrome.
Iwo anoshandiswawo mukuvhiya kwemaziso uye kuvhiyiwa kuchengetedza corneal hydration.
5. Zvakanakira:
Nekuda kweiyo viscosity yakakwirira, inogona kuwedzera nguva yekugara pane ocular pamusoro.
Zvinonyatsogadzirisa zviratidzo zvemaziso akaoma uye zvinopa nyaradzo.
6. Zvakaipa:
Vamwe vanhu vanogona kuona kusaona zvakanaka mushure mekuiswa nekuda kwekuwedzera viscosity.
Carboxymethylcellulose (CMC) madonhwe eziso:
1.Chemical chimiro:
CMC ndechimwe chinobva ku cellulose chakagadziridzwa nemapoka ecarboxymethyl.
Kuunzwa kweboka recarboxymethyl kunowedzera kunyungudika kwemvura, zvichiita kuti CMC ive polima inonyungudika nemvura.
2. Viscosity uye rheology:
CMC ziso madonhwe kazhinji ane yakaderera viscosity zvichienzaniswa HPMC ziso madonhwe.
Iyo yakaderera viscosity inobvumira kupinza nyore nyore uye nekukurumidza kupararira pamusoro peiyo ocular surface.
3. Nzira yekuita:
CMC inoita semafuta uye inonyorovesa, inovandudza kubvarura firimu kugadzikana.
Inobatsira kubvisa zviratidzo zvemaziso akaoma nekusimudzira kuchengetedza hunyoro paziso reziso.
4. Clinical application:
CMC ziso madonhwe anoshandiswa zvakanyanya kudzikisa yakaoma maziso zviratidzo.
Zvinowanzokurudzirwa kune vanhu vane nyoro kusvika pakati nepakati yakaoma eye syndrome.
5. Zvakanakira:
Nekuda kwekuderera kwayo viscosity, inopararira nekukurumidza uye iri nyore kudonha.
Zvinobudirira uye nekukurumidza kubvisa zviratidzo zvemaziso akaoma.
6. Zvakaipa:
Kuwedzera kazhinji dosing inogona kudikanwa kana ichienzaniswa nepamusoro viscosity magadzirirwo.
Dzimwe gadziriro dzinogona kunge dziine nguva diki yekuita pane yemaziso.
Kuenzanisa kuongorora:
1. Viscosity:
HPMC ine yakakwira viscosity, ichipa kuzorora-kwenguva refu uye kuchengetedzwa kwakasimba.
CMC ine yakaderera viscosity, inobvumira kukurumidza kupararira uye nyore kupinza.
2. Nguva yekuita:
HPMC inowanzopa nguva yakareba yekuita nekuda kwekukwira kwayo viscosity.
CMC ingangoda kuwanda kudzokororwa, kunyanya muzviitiko zveziso rakaomarara.
3. Kunyaradza nemurwere:
Vamwe vanhu vanogona kuona kuti HPMC ziso rinodonha pakutanga rinokonzera kudzima kwechinguvana kwekuona nekuda kwepamusoro viscosity.
CMC madonhwe eziso anowanzo kutenderwa zvakanaka uye anokonzera kushomeka kwekutanga kudzima.
4. Makiriniki ekurudziro:
HPMC inowanzokurudzirwa kune vanhu vane pakati kusvika kune yakaoma yakaoma eye syndrome.
CMC inowanzo shandiswa kune akapfava kusvika pakati nepakati akaoma maziso uye kune avo vanosarudza kushoma viscous formula.
Hydroxypropylmethylcellulose (HPMC) uye carboxymethylcellulose (CMC) madonhwe emaziso ese ari maviri akakosha sarudzo pakurapa yakaoma maziso zviratidzo. Chisarudzo pakati pezviviri izvi chinoenderana nezvido zvemurwere, kuoma kweziso rakaoma, uye nguva inodiwa yekuita. HPMC's high viscosity inopa dziviriro yenguva refu, nepo CMC yakaderera viscosity inopa zororo nekukurumidza uye inogona kunge iri sarudzo yekutanga kune vanhu vanonzwa nekusaona. Ophthalmologists uye varapi vekuchengetedza maziso vanowanzofunga nezvezvinhu izvi pavanenge vachisarudza madonhwe emeso ekuzora akakodzera kune varwere vavo, akagadzirirwa kukwidziridza nyaradzo uye zvinobudirira kubvisa yakaoma maziso zviratidzo.
Nguva yekutumira: Zvita-25-2023