Hydroxypropylmethylcellulose (HPMC) inotorwa selulosi inowanzoshandiswa mumaindasitiri akasiyana siyana, anosanganisira emishonga, kuvaka uye chikafu. Viscosity yayo inogona kusiyana zvichienderana nezvinhu zvakaita sehuremu hwayo hwemamorekuru, dhigirii rekutsiva, uye kugadzirisa kugadzirisa.
Nhanganyaya yeHydroxypropyl Methylcellulose (HPMC)
Hydroxypropyl methylcellulose is a semi-synthetic polymer inowanikwa nekemikari shanduko ye cellulose. Nekuda kwehunhu hwayo hwakasiyana, inoshandiswa zvakanyanya senge thickener, gelling agent, firimu rekare uye stabilizer mumashandisirwo akasiyana siyana.
Molecular chimiro uye kuumbwa
HPMC ine cellulose musana ine hydroxypropyl uye methoxy substituents. Iyo dhigirii yekutsiva (DS) inoreva avhareji nhamba yezvinotsiva pane anhydroglucose unit mucheni ye cellulose. Iyo chaiyo DS kukosha inokanganisa muviri uye makemikari zvimiro zveHPMC.
HPMC viscosity
Viscosity yakakosha parameter yeHPMC, kunyanya mumashandisirwo ayo anoshandisa kukora uye gelling zvivakwa.
Iyo viscosity yeHPMC mhinduro inobatwa nezvinhu zvakawanda:
1. Kurema kwema molecular
Iyo molecular huremu hweHPMC inokanganisa viscosity yayo. Kazhinji, yakakwirira molecular uremu HPMCs anowanzo kuburitsa yakakwirira viscosity mhinduro. Pane magiredhi akasiyana eHPMC pamusika, imwe neimwe iine yayo yakatarwa mamorekuru huremu renji.
2. Dhigirii rekutsinhanisa (DS)
Iwo maDS maitiro ehydroxypropyl uye methoxy mapoka anokanganisa kunyungudika uye viscosity yeHPMC. Yakakwirira DS tsika dzinowanzokonzera kuwedzera kunyungudika kwemvura uye zvigadziriso zvakakora.
3. Kuisa pfungwa
Iko kusungirirwa kweHPMC mune mhinduro chinhu chakakosha chinokanganisa viscosity. Sezvo kuisa pfungwa kunowedzera, viscosity inowanzowedzera. Hukama uhwu kazhinji hunotsanangurwa neKrieger-Dougherty equation.
4. Tembiricha
Tembiricha inokanganisawo viscosity yeHPMC mhinduro. Kazhinji kutaura, viscosity inoderera sezvo tembiricha inowedzera.
Nzvimbo dzekushandisa
Pharmaceuticals: HPMC inowanzoshandiswa mukugadzirwa kwemishonga, kusanganisira mahwendefa uye ophthalmic solutions, uko kunodzorwa kusunungurwa uye viscosity zvakakosha.
Kuvaka: Muindasitiri yekuvaka, HPMC inoshandiswa seyakakora muzvigadzirwa-simende kuvandudza kushanda uye kuchengetedza mvura.
Indasitiri Yechikafu: HPMC inoshandiswa seyakakora, stabilizer uye emulsifier mumashandisirwo echikafu.
Iyo viscosity yehydroxypropyl methylcellulose inzvimbo yakaoma inobatwa nezvakawanda zvinhu senge molecular uremu, dhigirii rekutsiva, kutarisisa uye tembiricha. Magiredhi akasiyana eHPMC anowanikwa kuti aenderane nemashandisirwo chaiwo, uye vagadziri vanopa tekinoroji data mapepa anotsanangura iyo viscosity renji yegiredhi rega rega pasi pemamiriro akasiyana. Vatsvagiri nevagadziri vanofanirwa kufunga nezvezvinhu izvi kuti vagadzirise zvivakwa zveHPMC kuti isangane nezvinodiwa zvezvavanoda kuita.
Nguva yekutumira: Jan-20-2024