Hydroxypropyl methylcellulose, inowanzozivikanwa seHPMC, inoshandiswa zvakanyanya mishonga yemishonga uye yekuwedzera chikafu.Nekuda kwekunyungudika kwayo kwakanakisa, kugona kusunga uye firimu-kugadzira zvivakwa, yakashandiswa zvakanyanya muindasitiri yemishonga.HPMC inowanzo shandiswa muindasitiri yechikafu seyakakora, emulsifier uye stabilizer.Kuchena kweHPMC kwakakosha kwakakosha mumaindasitiri emishonga uye ezvekudya sezvo zvichikanganisa kushanda nekuchengetedzeka kwechigadzirwa.Ichi chinyorwa chichakurukura kutsunga kweHPMC kuchena uye nzira dzayo.
Chii chinonzi HPMCs?
Hydroxypropylmethylcellulose (HPMC) is a cellulose ether inotorwa kubva kumethylcellulose.Huremu hwayo hwemamorekuru i10,000 kusvika 1,000,000 Daltons, uye ipfumbu chena kana isina-chena, isinganhuhwi uye isinganakidze.HPMC inonyungudika zviri nyore mumvura, uye zvakare inonyungudika mune zvimwe organic solvents senge ethanol, butanol, uye chloroform.Iyo ine zvimwe zvakasarudzika zvinhu zvakaita sekuchengetedza mvura, kukora uye kugona kusunga, izvo zvinoita kuti ive yakakodzera kune maindasitiri emishonga uye ezvekudya.
Kutsunga kweHPMC kuchena
Kuchena kweHPMC kunoenderana nezvakati wandei zvakaita sedhigirii rekutsiva (DS), hunyoro hwemukati uye madota.DS inomiririra huwandu hwemapoka ehydroxyl anotsiviwa nemapoka ehydroxypropyl mune cellulose molecule.Iyo yakakwira dhigirii yekutsiva inowedzera kunyungudika kweHPMC uye inovandudza kugona kugadzira firimu.Sezvineiwo, dhigirii yakaderera yekutsiva yaizokonzera kuderedzwa kunyungudika uye kushomeka kwekugadzira firimu.
HPMC Purity Determination Method
Pane nzira dzinoverengeka dzekuona kuchena kweHPMC, kusanganisira acid-base titration, elemental ongororo, yakakwira-performance liquid chromatography (HPLC), uye infrared spectroscopy (IR).Heano iwo tsanangudzo yeimwe neimwe nzira:
acid-base titration
Iyo nzira yakavakirwa pane neutralization reaction pakati peasidhi uye mapoka ekutanga muHPMC.Chekutanga, HPMC inonyungudutswa mune inonyungudutsa uye inozivikanwa vhoriyamu yeasidhi kana chigadziko chekugadzirisa inozivikanwa inowedzerwa.Titration yakaitwa kusvika pH yasvika kwayakarerekera.Kubva pahuwandu hweasidhi kana chigadziko chinopedzwa, chiyero chekutsiva chinogona kuverengerwa.
Elemental analysis
Elemental ongororo inoyera chikamu chechimwe nechimwe chinhu chiri mumuenzaniso, kusanganisira kabhoni, hydrogen, uye oxygen.Iyo dhigirii yekutsiva inogona kuverengerwa kubva kuhuwandu hwechimwe nechimwe chinhu chiripo mune HPMC sampuro.
Yakakwira Performance Liquid Chromatography (HPLC)
HPLC inzira inoshandiswa zvakanyanya yekuongorora iyo inoparadzanisa zvikamu zvemusanganiswa zvichienderana nekudyidzana kwavo neakamira uye nhare nhanho.MuHPMC, dhigirii rekutsiva rinogona kuverengerwa nekuyera reshiyo yehydroxypropyl kumapoka emamethyl mumuenzaniso.
Infrared Spectroscopy (IR)
Infrared spectroscopy inyanzvi yekuongorora inoyera kutorwa kana kutapurirana kwemwaranzi ye infrared nemuenzaniso.HPMC ine mapeaks ekunyudza akasiyana ehydroxyl, methyl uye hydroxypropyl, inogona kushandiswa kuona dhigirii rekutsiva.
Kuchena kweHPMC kwakakosha mumaindasitiri emishonga uye ezvekudya, uye kutsunga kwayo kwakakosha kuve nechokwadi chekuchengetedza uye kushanda kwechigadzirwa chekupedzisira.Nzira dzinoverengeka dziripo dzekuona kuchena kweHPMC, kusanganisira acid-base titration, elemental ongororo, HPLC, uye IR.Imwe neimwe nzira ine zvayakanakira nezvayakaipira uye inogona kusarudzwa zvinoenderana nezvinodiwa chaizvo zvekushandisa.Kuchengetedza kuchena kweHPMC, inofanirwa kuchengetwa munzvimbo yakaoma, inotonhorera kure nechiedza chezuva uye zvimwe zvinosvibisa.
Nguva yekutumira: Aug-25-2023