Hydroxypropyl methylcellulose (HPMC) i polymer inoshanda zvakasiyana-siyana inoshandiswa zvakanyanya mumaindasitiri akasiyana siyana, kusanganisira mishonga, zvizorwa, chikafu, uye kuvaka.Kugona kwayo kugadzira gels, mafirimu, uye mhinduro kunoita kuti ive yakakosha kune akawanda maapplication.Hydration yeHPMC inhanho yakakosha mumatanho mazhinji, sezvo ichigonesa iyo polymer kuratidza yainoda zvimiro zvakanaka.
1. Kunzwisisa HPMC:
HPMC inobva ku cellulose uye inogadzirwa nekurapa cellulose nepropylene oxide uye methyl chloride.Iyo inoratidzirwa nekunyungudika kwayo kwemvura uye kugona kuumba pachena, thermally reversible gels.Iyo dhigirii yehydroxypropyl uye methoxyl inotsiva inokanganisa zvimiro zvayo, kusanganisira solubility, viscosity, uye gelation maitiro.
2. Kukosha kweHidration:
Hydration yakakosha kuvhura mashandiro eHPMC.Kana HPMC iine hydrated, inotora mvura uye inoputika, zvichiita kuti pave nekuumbwa kwemhinduro ye viscous kana gel, zvichienderana nekugadzirisa uye mamiriro.Iyi hydrated state inogonesa HPMC kuita mabasa ayo anodiwa, sekukora, gelling, kugadzira firimu, uye kuchengetedza kuburitswa kwezvinodhaka.
3. Nzira dzeHidration:
Pane nzira dzakati wandei dze hydrating HPMC, zvichienderana nekushandisa uye mhedzisiro yaunoda:
a.Kupararira kweMvura Inotonhora:
Iyi nzira inosanganisira kuparadzira HPMC hupfu mumvura inotonhora uchikurudzira zvinyoro.
Kupararira kwemvura inotonhora kunofarirwa kudzivirira clumping uye kuve nechokwadi cheuniform hydration.
Mushure mekupararira, mhinduro inowanzo tenderwa kuti iwedzere hydrate pasi pekusagadzikana kuti uwane viscosity inodiwa.
b.Kupararira kweMvura Inopisa:
Nenzira iyi, HPMC hupfu inoparadzirwa mumvura inopisa, kazhinji patembiricha iri pamusoro pe80 ° C.
Mvura inopisa inofambisa kukurumidza hydration uye kupera kweHPMC, zvichikonzera mhinduro yakajeka.
Kuchengetedza kunofanirwa kutorwa kudzivirira kupisa kwakanyanya, izvo zvinogona kukanganisa HPMC kana kukonzera bundu kuumbwa.
c.Neutralization:
Mamwe maapplication anogona kusanganisira kusarerekera HPMC mhinduro nealkaline agents se sodium hydroxide kana potassium hydroxide.
Neutralization inogadzirisa pH yemhinduro, iyo inogona kukanganisa viscosity uye gelation zvimiro zveHPMC.
d.Solvent Exchange:
HPMC inogona zvakare kuvezwa nemvura nekutsinhana kwe solvent, kwainoparadzirwa mumvura-miscible solvent senge ethanol kana methanol yobva yachinjaniswa nemvura.
Solvent exchange inogona kubatsira kune zvikumbiro zvinoda kunyatso kudzora pamusoro pe hydration uye viscosity.
e.Pre-Hydration:
Pre-hydration inosanganisira kunyudza HPMC mumvura kana solvent isati yaibatanidza mumigadziro.
Iyi nzira inovimbisa kunyatso hydration uye inogona kubatsira pakuwana mhedzisiro inowirirana, kunyanya mukuumbwa kwakaoma.
4. Zvinhu Zvinokanganisa Hydration:
Zvinhu zvinoverengeka zvinokanganisa hydration yeHPMC:
a.Particle Size: Yakanyatsogayiwa HPMC poda hydrates zviri nyore kupfuura coarse particles nekuda kwekuwedzera kwenzvimbo.
b.Tembiricha: Tembiricha yepamusoro inowanzo mhanyisa hydration asi inogona zvakare kukanganisa viscosity uye gelation maitiro eHPMC.
c.pH: Iyo pH ye hydration yepakati inogona kukanganisa iyo ionization mamiriro eHPMC uye nekudaro ayo hydration kinetics uye rheological properties.
d.Kusanganisa: Kusanganisa kwakaringana kana kubvongodza kwakakosha kune yunifomu hydration uye kupararira kwezvikamu zveHPMC mune zvinonyungudutsa.
e.Concentration: The concentration of HPMC in the hydration medium inokanganisa viscosity, gel simba, uye zvimwe zvinhu zvemhinduro kana gel.
5. Zvikumbiro:
Hydrated HPMC inowana zvikumbiro zvakasiyana mumaindasitiri akasiyana siyana:
a.Pharmaceutical Formulations: Mune mahwendefa ekuputira, anodzorwa-kuburitsa matrices, ophthalmic mhinduro, uye kumiswa.
b.Zvokudya Zvigadzirwa: Sezvinoita thickener, stabilizer, kana firimu-forming agent mumasosi, mapfekero, zvigadzirwa zvemukaka, uye confectionery.
c.Cosmetics: Mumafuta, lotions, gels, uye mamwe magadzirirwo ekugadzirisa viscosity uye emulsification.
d.Zvishandiso Zvekuvaka: Muzvigadzirwa-simende, zvinonamira mataira, uye zvinopa kuvandudza kushanda, kuchengetedza mvura, uye kunamatira.
6. Kudzora Hunhu:
Kushanda hydration yeHPMC yakakosha pakuita kwechigadzirwa uye kuenderana.Matanho ekudzora kunaka anogona kusanganisira:
a.Particle Size Ongororo: Kuve nechokwadi chekufanana kwekugovera saizi yechikamu kuti uwedzere hydration kinetics.
b.Viscosity Measurement: Kutarisisa viscosity panguva ye hydration kuti uwane iyo inodiwa kuenderana kune yakarongwa application.
c.pH Monitoring: Kudzora iyo pH ye hydration yepakati kukwirisa hydration uye kudzivirira kudzikisira.
d.Microscopic Examination: Kutariswa kwekuona kwema hydrated samples pasi pemaikorosikopu kuti iongorore kupararira kwechikamu uye kuvimbika.
7. Mhedziso:
Hydration inzira yakakosha mukushandisa zvivakwa zveHPMC kune akasiyana maapplication.Kunzwisisa nzira, zvinhu, uye nhanho dzekudzora mhando dzakabatanidzwa ne hydration kwakakosha pakugadzirisa kuita kwechigadzirwa uye kuve nechokwadi chekuenderana mukuumbwa.Nekuziva iyo hydration yeHPMC, vaongorori uye vanogadzira vanogona kuvhura kugona kwayo kuzere kune akasiyana maindasitiri, kutyaira hunyanzvi uye kugadzirwa kwechigadzirwa.
Nguva yekutumira: Mar-04-2024