Kugadzirira Hydroxypropyl Methylcellulose (HPMC) coating solution inzira yakakosha mumaindasitiri emishonga uye ezvekudya.HPMC inowanzo shandiswa polima mukugadzira mafomati nekuda kweakanakisa ekugadzira firimu zvimiro, kugadzikana, uye kuenderana neakasiyana anoshanda zvinhu.Coating mhinduro dzinoshandiswa kupa zvidziviriro, kudzora kuburitsa profiles, uye kunatsiridza kutaridzika uye kushanda kwemapiritsi, capsules, uye mamwe akasimba dosage mafomu.
1. Zvishandiso Zvinodiwa:
Hydroxypropyl Methylcellulose (HPMC)
Solvent (kazhinji mvura kana musanganiswa wemvura nedoro)
Plasticizer (kusarudza, kuvandudza kushanduka kwefirimu)
Zvimwe zvinowedzera (zvichida, senge colorants, opacifiers, kana anti-tacking agents)
2. Midziyo Inodiwa:
Kusanganisa mudziyo kana mudziyo
Stirrer (mechanical kana magnetic)
Kuyera mwero
Heating source (kana zvichidikanwa)
Sieve (kana zvichidiwa kubvisa mapundu)
pH mita (kana pH kugadzirisa kuchidikanwa)
Chengetedzo giya (magirovhosi, gogi, lab jasi)
3. Maitiro:
Danho 1: Kuyera Zvisungo
Edza huwandu hunodiwa hweHPMC uchishandisa huremu chiyero.Huwandu hunogona kusiyana zvichienderana nekusarudzika kwaidiwa kweiyo coating solution uye saizi yebatch.
Kana uchishandisa plasticizer kana zvimwe zvinowedzera, yera huwandu hunodiwa zvakare.
Danho 2: Kugadzirira kwe Solvent
Sarudza rudzi rwekunyungudutsa kunoshandiswa zvichienderana nekushandiswa uye kuenderana neanoshanda zvinhu.
Kana ukashandisa mvura sechinhu chinonyungudutsa, ita shuwa kuti ndeyekuchena kwepamusoro uye zvichida yakasvibiswa kana kuti deionized.
Kana ukashandisa musanganiswa wemvura nedoro, sarudza chiyero chakakodzera chinoenderana nekunyungudika kweHPMC uye hunhu hunodiwa hwekugadzirisa.
Danho rechitatu: Kusanganisa
Isa mudziyo wekuvhenganisa pamushonga uye wobva wawedzera solvent.
Tanga kubvongodza zvinonyungudutsa zvine mwero.
Zvishoma nezvishoma wedzera iyo pre-yakayerwa HPMC hupfu mune inomutsa inonyungudutsa kuti usapinda.
Ramba uchikurudzira kusvika iyo HPMC poda yaparadzirwa zvakafanana musolvent.Iyi nzira inogona kutora nguva, zvichienderana nekusangana kweHPMC uye kugona kwemudziyo unomutsa.
Nhanho 4: Kupisa (kana zvichidikanwa)
Kana iyo HPMC ikasanyungudika zvachose pakupisa kwekamuri, kudziyisa zvinyoro kungave kuri madikanwa.
Pisa musanganiswa uchikurudzira kusvika HPMC yanyungudika zvachose.Chenjera kuti usapisa, sezvo tembiricha yakawandisa inogona kukanganisa HPMC kana zvimwe zvikamu zvemhinduro.
Nhanho 5: Kuwedzera kwePlasticizer uye Zvimwe Zvinowedzerwa (kana zvichibvira)
Kana ukashandisa plasticizer, wedzera kune mhinduro zvishoma nezvishoma uchikurudzira.
Saizvozvo, wedzera chero zvimwe zvinodiwa zvekuwedzera senge colorants kana opacifiers panguva ino.
Nhanho 6: pH Kugadziriswa (kana zvichidikanwa)
Tarisa pH yemhinduro yekuputira uchishandisa pH mita.
Kana iyo pH iri kunze kweiyo yaidiwa renji yekugadzikana kana kuenderana zvikonzero, gadzirisa nekuwedzera zvidiki zvidiki zveasidhi kana zvakakosha mhinduro zvinoenderana.
Sungai mhinduro yacho zvakakwana mushure mekuwedzera kwega kwega uye ongorora zvakare pH kusvikira chiyero chaunoda chawanikwa.
Danho rechinomwe: Kusanganiswa kwekupedzisira uye kuyedzwa
Kana zvese zvikamu zvawedzerwa uye zvakanyatsosanganiswa, ramba uchikurudzira kwemamwe maminetsi mashoma kuti uone homogeneity.
Ita chero inodiwa yemhando bvunzo senge viscosity kuyerwa kana kutarisa kwekuona kune chero zviratidzo zvechikamu chechinhu kana kupatsanurwa kwechikamu.
Kana zvichidiwa, pfuudza mushonga nemusefa kuti ubvise mapundu asara kana zvidimbu zvisina kunyungudika.
Nhanho 8: Kuchengeta uye Packaging
Chinja iyo yakagadziriswa HPMC yekupotera mhinduro mumidziyo yekuchengetera yakakodzera, ingangoita amber mabhodhoro egirazi kana emhando yepamusoro midziyo yepurasitiki.
Nyora midziyo ine ruzivo rwakakosha senge batch nhamba, zuva rekugadzirira, kutarisisa, uye kuchengetedza mamiriro.
Chengetedza mhinduro munzvimbo inotonhorera, yakaoma yakachengetedzwa kubva kuchiedza uye unyoro kuchengetedza kugadzikana kwayo uye hupenyu hwesherufu.
4. Mazano uye Mafungiro:
Nguva dzose tevera maitiro akanaka emurabhoritari uye mirairo yekuchengetedza paunenge uchibata makemikari nemidziyo.
Chengetedza hutsanana uye sterility mukati megadziriro yekugadzirira kudzivirira kusvibiswa.
Edza kuenderana kwemhinduro yekuputira neyakagadzirirwa substrate (mahwendefa, makapu) pamberi pehombe-chiyero application.
Ita zvidzidzo zvekugadzikana kuti uongorore kushanda kwenguva refu uye kuchengetedza mamiriro ekugadzirisa kugadzirisa.
Nyora maitiro ekugadzirira uye chengeta zvinyorwa zvezvinangwa zvekutonga kwemhando uye kutevedza kwemitemo.
Nguva yekutumira: Mar-07-2024