Kunyungudutsa Hydroxypropyl Methylcellulose (HPMC) mumvura chinhu chinowanzoitwa mumaindasitiri akasiyana siyana, kusanganisira zvemishonga, chikafu, zvizorwa, uye kuvaka.HPMC ndeye cellulose inotorwa inoumba yakajeka, isina ruvara, uye viscous mhinduro kana yakasanganiswa nemvura.Iyi mhinduro inoratidza yakasarudzika zvivakwa senge kukora, kusunga, kugadzira firimu, uye kusimudzira kuburitswa kwezvinhu zvinoshanda.Kuparara kweHPMC mumvura kunosanganisira matanho chaiwo ekuona kupararira kwakanaka uye kufanana.
Nhanganyaya kuHPMC:
Hydroxypropyl Methylcellulose (HPMC) isiri-ionic cellulose ether inotorwa kubva kune yakasikwa polymer cellulose.Inogadzirwa nekurapa cellulose nepropylene oxide uye methyl chloride.HPMC inoshandiswa zvakanyanya mumaindasitiri akasiyana nekuda kweakanakisa kugadzira firimu, kukora, kudzikamisa, uye kuchengetedza mvura.Iwo ekutanga mashandisirwo eHPMC anosanganisira:
Pharmaceuticals: Inoshandiswa sebhainda, firimu rekare, viscosity modifier, uye inodzorwa-inoburitsa mumiriri mumapiritsi, capsules, mafuta ekuzora, uye kumiswa.
Indasitiri Yechikafu: Inoshandiswa seyakakora, inodzikamisa, emulsifier, uye inochengetedza hunyoro muzvigadzirwa zvekudya zvakaita sesosi, mukaka, uye zvinhu zvakabikwa.
Kuvaka: Inoshanda sechinhu chinochengeta mvura, chinonamira, uye chikobvu mune simende-based zvinhu, gypsum-based plasters, uye mataira anonamira.
Cosmetics: Inoshanda seyakakora, firimu rekare, uye emulsion stabilizer mune lotions, makirimu, shampoos, uye zvigadzirwa zvekuchengeta munhu.
Dissolution process yeHPMC mumvura:
Kunyungudutsa HPMC mumvura kunosanganisira akati wandei matanho ekuwana yunifomu uye yakagadzikana mhinduro:
Kusarudzwa kweHPMC Giredhi: Sarudza giredhi rakakodzera reHPMC zvichibva pane inodiwa viscosity, particle size, uye substitution level.Magiredhi akasiyana anopa madhigirii akasiyana eviscosity uye solubility maitiro.
Kugadzirira kweMvura: Shandisa mvura yakacheneswa kana yakasvibiswa kugadzirira mhinduro.Unhu hwemvura hunogona kukanganisa zvakanyanya kuparara kwemaitiro uye maitiro ekupedzisira mhinduro.Dzivisa kushandisa mvura yakaoma kana mvura ine tsvina inogona kukanganisa kuparara.
Kuyera uye Kuyera: Kuyera nemazvo huwandu hunodiwa hweHPMC uchishandisa chiyero chedhijitari.Iyo yakakurudzirwa kusungirirwa kweHPMC mumvura inosiyana zvichienderana neyakagadzirirwa kushandiswa.Kazhinji, kutarisisa kubva pa0.1% kusvika ku5% w/w kwakajairika kune akawanda maapplication.
Hydration Stage: Mwaya yakayerwa HPMC zvishoma nezvishoma uye zvakaenzana pamusoro pemvura uchitenderedza uchienderera.Dzivisa kuwedzera HPMC muzvikamu zvakakura kudzivirira kuumbwa kwemapundu kana agglomerates.Bvumira HPMC kuti hydrate uye kupararira zvishoma nezvishoma mumvura.
Kusanganisa uye Kubvongodza: Shandisa yakakodzera midziyo yekusanganisa senge magineti inosimudzira, propeller mixer, kana high-shear mixer kufambisa yunifomu kupararira kwezvikamu zveHPMC mumvura.Chengetedza kubvongodza zvinyoro kudzivirira kupupuma furo kana kupinda nemhepo.
Temperature Kudzora: Tarisa uye kudzora tembiricha panguva yekuparara.Muzviitiko zvakawanda, tembiricha yekamuri (20-25 ° C) inokwana pakunyungudutsa HPMC.Nekudaro, kukurumidza kunyungudika kana kuumbwa kwakananga, tembiricha yakakwira inogona kudiwa.Dzivisa kupisa, sezvo inogona kukanganisa iyo polymer uye kukanganisa mhinduro zvivakwa.
Nguva yeDisolution: Kuparara kwakazara kweHPMC kunogona kutora maawa akati wandei, zvichienderana negiredhi, saizi yechikamu, uye kusimba kwekushushikana.Ramba uchikurunga kusvika mhinduro yave pachena, pachena, uye isina zvidimbu zvinooneka kana agglomerates.
pH Kugadziriswa (kana zvichidikanwa): Mune mamwe magadzirirwo, pH kugadziridzwa kungave kuri madikanwa kukwirisa kugadzikana uye kuita kweiyo HPMC mhinduro.Shandisa yakakodzera buffering agents kana gadzirisa pH uchishandisa maasidhi kana mabhesi maererano nezvinodiwa chaizvo.
Kusefa (kana zvichidiwa): Mushure mekunyungudika zvachose, sefa mhinduro yeHPMC kuburikidza nesefa yakanaka mesh kana sefa bepa kuti ubvise chero zvidimbu zvisina kunyungudika kana tsvina.Iyi nhanho inovimbisa kujeka uye homogeneity yemhinduro.
Kuchengetedza uye Kugadzikana: Chengetedza mhinduro yeHPMC yakagadzirwa mumidziyo yakachena, isina mweya kure nechiedza chezuva uye tembiricha yakanyanyisa.Mhinduro dzakachengetwa zvakanaka dzinoramba dzakagadzikana kwenguva yakareba pasina shanduko huru muviscosity kana zvimwe zvivakwa.
Zvinhu Zvinokanganisa Kuparara kweHPMC:
Zvinhu zvakati wandei zvinogona kukanganisa maitiro ekumisa uye zvimiro zveiyo HPMC mhinduro:
Particle Size uye Giredhi: Yakatsetseka magiredhi ehupfu eHPMC anonyungudika zviri nyore kupfuura zvidimbu zvakakasharara nekuda kwekuwedzera kwenzvimbo uye nekukurumidza hydration kinetics.
Tembiricha: Tembiricha yepamusoro inomhanyisa mwero wekunyungudika weHPMC asi zvakare inogona kutungamira mukurasikirwa kweviscosity kana kuderera mumamiriro akanyanya.
Agitation Speed: Kwakaringana kubvongodza kunovimbisa kupararira kwakafanana kweHPMC zvimedu uye inosimudzira kukurumidza kupera.Kunyanya kubvongodza kunogona kuunza mabhuru emhepo kana furo mumushonga.
Hunhu hwemvura: Hunhu hwemvura inoshandiswa pakunyungudutswa hunokanganisa kujeka, kugadzikana, uye viscosity yeHPMC mhinduro.Mvura yakacheneswa kana yakasvibiswa inosarudzwa kuderedza kusvibiswa uye ions zvinogona kukanganisa kupera.
pH: Iyo pH yemhinduro inogona kukanganisa kunyungudika uye kugadzikana kweHPMC.Kugadzirisa iyo pH mukati meiyo yakakwana renji yeiyo chaiyo giredhi yeHPMC inogona kuwedzera kuparara nekuita.
Ionic Simba: Yakanyanya kuwanda yemunyu kana ion mune mhinduro inogona kukanganisa HPMC kuparara kana kukonzera gelation.Shandisa mvura yakasvibiswa kana kugadzirisa munyu wemunyu sezvinodiwa.
Shear Forces: High-shear kusanganisa kana kugadzirisa mamiriro anogona kukanganisa rheological zvivakwa uye kuita kweiyo HPMC mhinduro, kunyanya mumaindasitiri ekushandisa.
Mazano ekugadzirisa matambudziko:
Kana iwe ukasangana nekuomerwa mukupedza HPMC kana kusangana nenyaya nemhando yemhinduro, funga anotevera matipi ekugadzirisa matambudziko:
Wedzera Kusarudzika: Wedzera kusanganisa kwakasimba kana shandisa yakasarudzika yekusanganisa michina kusimudzira kuri nani kupararira uye kuparara kweHPMC zvimedu.
Gadzirisa Tembiricha: Gadzirisa mamiriro ekushisa mukati meiyo yakakurudzirwa renji kuti ifambise nekukurumidza kupera pasina kukanganisa kugadzikana kwepolymer.
Chikamu Chekuderedza Saizi: Shandisa magiredhi akakwenenzverwa eHPMC kana shandisa nzira dzekudzikisa saizi senge milling kana micronization kuvandudza dissolution kinetics.
pH Kugadziriswa: Tarisa pH yemhinduro uye gadzirisa sezvinodiwa kuchengetedza mamiriro akakwana eHPMC solubility uye kugadzikana.
Hunhu hweMvura: Ita shuwa kuchena uye kunaka kwemvura inoshandiswa pakunyungudutswa nekushandisa kwakakodzera kusefa kana nzira dzekuchenesa.
Muedzo Wekuenderana: Ita zvidzidzo zvekuenderana nezvimwe zvekugadzira zvinongedzo kuona chero kudyidzana kana kusapindirana kunogona kukanganisa kupera.
Bvunza Manongedzo eVagadziri: Tarisa kune kurudziro dzemugadziri uye nhungamiro kune chaiwo mamakisi eHPMC maererano nemamiriro ekuparara, nzvimbo dzevasungwa, uye zano rekugadzirisa matambudziko.
Dissolving Hydroxypropyl Methylcellulose (HPMC) mumvura inhanho yakakosha mumaindasitiri akasiyana siyana, anosanganisira mishonga, chikafu, kuvaka, uye zvekuzora.Nekutevera maitiro akakurudzirwa uye nekutarisa zvinhu zvakakosha senge saizi, tembiricha, kusagadzikana, uye mhando yemvura, unogona kuwana yunifomu uye yakagadzikana HPMC mhinduro ine inodiwa rheological properties.Pamusoro pezvo, maitiro ekugadzirisa matambudziko uye nzira dzekugadzirisa dzinogona kubatsira kukunda matambudziko uye kuona kuparara kwakabudirira kweHPMC kune akasiyana maapplication.Kunzwisisa iyo disolution process uye yayo
Nguva yekutumira: Kurume-09-2024