HydroxyPropyl methylcellose (HPMC) ishandare yakati wandei inoshandiswa zvakanyanya muindasitiri yemishonga yemishonga, kunyanya mukugadzira piritsi. Semunhu cellulose derivative, HPMC ine huwandu hwenzvimbo dzinoshanda dzinobatsira pakuita patafura. Iyo compound inotorwa kubva ku cellulose kuburikidza neyekutevedzana kwemakemikari ekugadziridzwa, zvichikonzera zvigadzirwa zvine zvimiro zvakasarudzika zvakakodzera kune dzakasiyana siyana dzekushandisa. Muchipamara piritsi, HPMC ine mashandisiro akasiyana, kusanganisira kudzora zvinodhaka, kuvandudza piritsi yekubatanidzira, uye kuvandudza kugadzikana kwakazara kweiyo dosge fomu.
1. Binders uye magonts egrander:
HPMC inoita kunge binder mune piritsi mafomu, ichibatsira kusunga izvo zvinoshandiswa pamwe uye kudzivirira piritsi risati ratanga. Izvo zvinoshandiswawo semumiriri wegirini panguva yekugadzira, ichibatsira mushonga uye musanganiswa wekushandisa kuti ugadzire granules.
2. Matrix achiumba vamiririri kuti abatsirwe:
Chimwe chezvakakura zvakanakira kushandisa HPMC mukuumbwa kwe piritsi ndiko kugona kwayo kudzora kusunungurwa kwezvinodhaka. Kana ichishandiswa sematrix yaimbova, HPMC inoumba gel-yakaita matrix pamusoro pekuonana nemvura, ichibvumira kuburitswa kwekusunungurwa uye kudzorwa kwemushonga. Izvi zvinonyanya kukosha kuti zvinodhaka neanotetepa mawindocic windows kana izvo zvinoda kwenguva refu chiito.
3. Kuparadzanisa:
Kuwedzera kune basa rayo seye binder, HPMC zvakare inoita sekuparadzaniswa mukugadzirisa piritsi. Kana iyo piritsi ichisangana nejira rine gastric juices, hpmc clyns uye inokanganisa iyo piritsi chimiro, ichikurudzira kukurumidza kusunungurwa kwezvinodhaka. Izvi zvinonyanya kubatsira pakureba kwekuburitswa.
4. Firimu kuunganidza:
HPMC inowanzo shandiswa kune piritsi firimu yekuvhara. HpMC mafomu mafirimu anowedzera kutaridzika kwemapiritsi, ipa kuchengetedzwa kubva kune zvakatipoteredza zvinhu, uye zvinogona zvakare kushandiswa nekuda kwekuravira. Iyo firimu inobatanidza maitiro ndeyekushandisa HPMC Solution pane pamusoro pematafura uye gadzira yunifomu uye yakajeka yekuvhara mushure mekuoma.
5. Dzora porosity uye permeabilgi modifiers:
Mahwendefa anogona kuda zvakanyatso porosity uye fungidziro maitiro ekuzadzisa iyo yaunoda dissolution profile. HPMC inogona kushandiswa kushandura iyo porosity uye kugadzikana kwehwendefa, kubata kusunungurwa kwezvinodhaka. Izvi zvakakosha kuti uwane iyo inodiwa pharmacokineticic profile yemushonga.
6. Piritsi Lubricant:
HPMC inoita sehwendefa yebhiramu, ichidzora kupokana pakati pemahwendefa uye kugadzirisa michina nzvimbo panguva yekugadzira. Izvi zvinopa mari inobudirira piritsi yekugadzira piritsi uye mahwendefa akasimbisa haanamatire kumidziyo.
7. Mucoadhemes:
Mune mamwe mafambiro, kunyanya kune buccal kana omarara mucosal zvinodhaka, HPMC inogona kushandiswa seye mucoadhesive mumiririri. Iyo inobatsira kuwedzera iyo nguva yekugara yeiyo dosge fomu pane mucosal pamusoro, nekudaro inosimudzira zvinodhaka.
8. Kugadzikana Enhancer:
HPMC inobatsira kuvandudza kugadzikana kwekugadziriswa kwe piritsi nekudzivirira kunyorova kwekunyorova uye kuchengetedza mushonga kubva kune zvakatipoteredza zvinhu. Izvi zvinonyanya kukosha kune zvinodhaka izvo zvine hanya nekunyorova kana kufungidzira kusvibiswa.
9. Kuenderana nevamwe vaenzanisa:
HPMC ine zvakanaka zvinoenderana nemhando dzakasiyana-siyana dzezvisikwa zvinowanzoshandiswa mukugadzira piritsi. Uku kuwirirana kunoita kuti zvive nyore kuumbwa kwemahwendefa zvine zvinhu zvakasiyana-siyana zvezvinodhaka uye zvimwe zvinoshandiswa.
HydroxyPropyl methylcellose (HPMC) inoita basa rakakosha mukugadzirisa piritsi, kupa mabasa akawanda anobatsira kuvandudza maitiro ese uye kushanda kweiyo dosge fomu. Zvikumbiro zvinobva kune binders uye magonendi egirini ekudzora kudzorwa matrix matsari, firimu inovhara zvinhu, lubricants uye kugadzikana kuvanzwisisa. Iko kuwanda kweHPMC kunoita kuti ive yakakosha muzvimiro zvechinangwa, uye kushandiswa kwayo kwakaramba kuchiratidza kukosha kwayo mukuzadzisa zvinodikanwa zvinodhaka zvinodhaka.
Kutumira Nguva: Dec-25-2023