Hydroxypropyl methylcellulose (HPMC) i polymer inoshanda zvakasiyana-siyana iyo inoshandiswa zvakanyanya muindasitiri yemishonga, kunyanya mukugadzira mapiritsi.Sekubuda kweselulosi, HPMC ine huwandu hwezvinhu zvinoshanda izvo zvinopa kune yakazara piritsi kuita.Iyo komputa inotorwa kubva kune cellulose kuburikidza neakatevedzana emakemikari ekugadzirisa, zvichikonzera zvigadzirwa zvine yakasarudzika zvivakwa zvakakodzera kune akasiyana maapplication.Mukugadzirwa kwehwendefa, HPMC ine kushandiswa kwakasiyana-siyana, kusanganisira kudzora kuburitswa kwezvinodhaka, kuvandudza kubatana kwehwendefa, uye kuwedzera kugadzikana kwese kwefomu redosi.
1. Binders uye granulating agents:
HPMC inoshanda sebhainda mukuumbwa kwepiritsi, ichibatsira kusunga zvinosanganiswa pamwe chete uye kudzivirira kuparara kwehwendefa risati rasvika.Inoshandiswawo senge granulating agent panguva yekugadzira, kubatsira mushonga uye excipient musanganiswa kugadzira granules.
2. Matrix ekugadzira maajenti ekusunungurwa kunodzorwa:
Imwe yemabhenefiti makuru ekushandisa HPMC mukuumbwa kwehwendefa kugona kwayo kudzora kuburitswa kwezvinodhaka.Kana ichishandiswa seyaimbova matrix, HPMC inoumba gel-senge matrix payakasangana nemvura, ichibvumira kuchengetedzwa uye kudzorwa kuburitswa kwemushonga.Izvi zvinonyanya kukosha kune zvinodhaka zvine mahwindo ekurapa akamanikana kana zvinoda kuita kwenguva refu.
3. Disintegrant:
Pamusoro pebasa rayo sebhainda, HPMC inoshandawo senge disintegrant mukugadzira piritsi.Kana piritsi racho rasangana negastric juices, HPMC inoputika uye inovhiringidza chimiro chehwendefa, ichikurudzira kusunungurwa kwemishonga nokukurumidza.Izvi zvinonyanya kubatsira kune kukurumidza kuburitswa mafomu.
4. Kupfekedzwa kwefirimu:
HPMC inowanzo shandiswa papiritsi firimu coating.HPMC inoumba mafirimu anowedzera kutaridzika kwemapiritsi, anopa dziviriro kubva kune zvakatipoteredza zvinhu, uye anogona zvakare kushandiswa kuravira masking.Iyo firimu yekuputira maitiro ndeyekuisa HPMC mhinduro pamusoro pemahwendefa uye kuumba yunifomu uye yakajeka yekupfeka mushure mekuoma.
5. Kudzora porosity uye permeability modifiers:
Mapiritsi anogona kuda chaiyo porosity uye permeability hunhu kuti uwane yaunoda dissolution profile.HPMC inogona kushandiswa kushandura porosity uye permeability yemapiritsi, zvichikanganisa kuburitswa kwezvinodhaka.Izvi zvakakosha kuti uwane inodiwa pharmacokinetic mbiri yemushonga.
6. Tablet Lubricant:
HPMC inoshanda semafuta ekuzora papiritsi, ichideredza kupokana pakati pemahwendefa uye nzvimbo dzekugadzira michina panguva yekugadzira.Izvi zvinogonesa inoshanda kugadzirwa kwepiritsi uye inovimbisa kuti mahwendefa haanamatira kumidziyo.
7. Mucoadhesives:
Mune mamwe magadzirirwo, kunyanya kune buccal kana oral mucosal zvinodhaka kuendesa, HPMC inogona kushandiswa semucoadhesive agent.Inobatsira kuwedzera nguva yekugara yedoseji fomu pane mucosal pamusoro, nekudaro ichiwedzera kutora zvinodhaka.
8. Kugadzikana kwekusimudzira:
HPMC inobatsira kuvandudza kugadzikana kwemapiritsi ekugadzira nekudzivirira kunwa kwemwando uye kudzivirira mushonga kubva kune zvakatipoteredza.Izvi zvinonyanya kukosha kune zvinodhaka zvinonzwisisika kune unyoro kana kuti zvinowanzosvibiswa.
9. Kugarisana nevamwe vabatsiri:
HPMC ine kugarisana kwakanaka neyakasiyana-siyana excipients inowanzoshandiswa mukugadzira piritsi.Uku kugarisana kunofambisa kuumbwa kuri nyore kwemapiritsi ane zvakasiyana siyana zvezvinodhaka uye zvimwe zvinongedzo.
Hydroxypropyl methylcellulose (HPMC) inoita basa rakakosha mukuumbwa kwepiritsi, ichipa akawanda mabasa anobatsira kuvandudza kuita kwese uye kushanda kwefomu redosi.Zvishandiso zvinotangira kubva kumabhainda uye granulating agents kune anodzorwa kuburitsa matrix ekare, firimu rekupfekedza zvinhu, mafuta ekuzora uye kugadzikana ekuwedzera.Iko kushandiswa kwakasiyana-siyana kweHPMC kunoita kuti ive chinhu chakakosha mukugadzirwa kwemishonga, uye kuenderera kwayo kushandiswa kunoratidza kukosha kwayo mukuwana mhedzisiro inodiwa yekuunza zvinodhaka.
Nguva yekutumira: Zvita-25-2023