Hydroxypropylmethylcylosellose (HPMC), sekujairika inoshandiswa hydrophilic polymer muindasitiri yemishonga, inoshandiswa zvakanyanya muzvimiro zvebiritsi, zvakadzorwa kuburitswa uye zvimwe zvekutumira zvinodhaka. Imwe yeiyo yakakosha zvivakwa zveHPMC ndeyekuchengetedza mvura, iyo inokanganisa mashandiro aro seye mishonga yekunyora. Munyaya ino, isu tichazotarisa zvinhu zvakakosha zvinokanganisa kuchengetwa kwemvura kweHPMC, kusanganisira molecular uremu, kutsiva mhando, kusangana, uye Ph.
sreek inoremerwa
Kurema kwemanyorerwe kweHPMC kunoita basa rakakosha mukuona huwandu hwayo hwekutenderwa kwemvura. Muzhinji, yakakwira molecular uremu hpmc iri hydrophilic pane yakaderera molecular uremu hpmc uye inogona kutora yakawanda mvura. Izvi zvinodaro nekuti yakakwira molecular uremu hpmc Nekudaro, zvinofanirwa kucherechedzwa kuti yakanyanya kukwirisa molecular uremu HPMC ichakonzera matambudziko akadai seVisaStosity uye kugadzirisa matambudziko.
imwe nzira
Chimwe chinhu chinobata chinokonzeresa mvura yekuchengetwa kweHPMC ndiyo mhando yekutsiva. HPMC inowanzouya mumhando mbiri: hydroxyprusyl-yakatsiva uye nzira-yakatsiviwa. Iyo hydroxypruppropyl-yakatsiviwa mhando ine yakakwira mvura yekukwana kwekuwedzera pane iyo nzira-yakatsanangurwa mhando. Izvi zvinodaro nekuti iyo hydroxypruspropyl boka riripo muHPMC Molecule uye inowedzera kushamwaridzana kweHPMC yemvura. Mukupesana, iyo nzira-yakatsanangurwa mhando ishoma hydrophilic uye saka ine yakadzika mvura yekuchengetwa kwemvura. Naizvozvo, dzimwe nzira dzeHPMC dzinofanirwa kusarudzwa zvakanyatsonaka zvichienderana nezvinhu zvaunoda zvechigadzirwa chekupedzisira.
isa pfungwa
Iko kusvinura kweHPMC kunobatawo mari yayo yekuchengeta mvura. Pakukona kwakaderera, HPMC haigadzike chimiro chemagindu, saka kuchengetwa kwemvura kwaro kwakaderera. Sezvo kusangana kweHPMC kwakawedzera, mamalecha emolymer akatanga kupinda, achigadzira chimiro cheGel. Iyi gel network inobata uye inochengetedza mvura, uye iyo yekuchengetwa kwemvura yeHPMC inowedzera neyekusimbisa. Nekudaro, zvinofanirwa kucherechedzwa kuti yakanyanya kujairika yeHPMC inotungamira kumatambudziko ekuumbwa senge viscosity uye kugadzirisa matambudziko. Naizvozvo, kusunganidzwa kweHPMC inoshandiswa kunofanirwa kuve yakagadzirirwa kuzadzisa iyo inodiwa mvura yekuchengetwa kwekuchengetedza paunenge uchidzivirira matambudziko ataurwa pamusoro apa.
Ph kukosha
Iyo PH Kukosha kwenzvimbo iyo HPMC inoshandiswa zvakare ichakanganisawo mvura yayo yekuchengeta mvura. Iyo HPMC chimiro ine anonic mapoka (-coo-) uye hydrophilic etylcellose mapoka (-OOOH). Iyo ionization ye-mapoka- mapoka ari pH anoenderana, uye degree ravo reIonization rinowedzera nePH. Naizvozvo, HPMC ine yakakwira mvura yekuchengetwa yakakwira pakakwirira pH. Pakaderera pH, iyo-boka rinojekeswa uye hydrophilicity yakaderera, zvichikonzera mune yakadzika mvura yekuchengetedza mvura. Naizvozvo, iyo phim yakanamatira inofanirwa kuve yakagadzirirwa kuzadzisa iyo inodiwa mvura yekuchengetwa kweHPMC.
mumhedziso
Mukupedzisa, iyo mvura yekuchengetwa kwemvura yeHPMC chinhu chakakosha chinokanganisa mashandiro azvo semishonga yemishonga. Zvinhu zvakakosha zvine chekuita nekuchengetwa kwemvura kweHPMC inosanganisira iyo molecular uremu, kutsiva mhando, kusunganidzwa uye ph kukosha. Nekunyatsogadzirisa zvinhu izvi, iyo mvura yekuchengetwa kweHPMC inogona kuve yakagadzirirwa kuzadzisa zvivakwa zvemagumo zvechigadzirwa chekupedzisira. Vagadziri venhau vanowana uye vagadziri vanofanirwa kutarisisa zvinhu izvi kuti vaone zvakakwirira uye kuita kweHPMC-yakavakirwa zvinogadzirwa zvinodhaka.
Kutumira Nguva: Aug-05-2023