Hydroxypropylmethylcellulose (HPMC), seanowanzo shandiswa hydrophilic polymer muindasitiri yemishonga, inoshandiswa zvakanyanya mukuputira mapiritsi, inodzorwa kuburitsa magadzirirwo uye mamwe masisitimu ekutumira zvinodhaka.Chimwe chezvinhu zvakakosha zveHPMC kugona kwayo kuchengetedza mvura, izvo zvinokanganisa kushanda kwayo semushonga wemishonga.Muchikamu chino, tichaongorora zvinhu zvakakosha zvinokanganisa kuchengetwa kwemvura kweHPMC, kusanganisira uremu hwemamorekuru, rudzi rwekutsiva, kutarisisa, uye pH.
molecular uremu
Huremu hwehuremu hweHPMC hunoita basa rakakosha mukuona kugona kwayo kuchengetedza mvura.Kazhinji, yakakwirira molecular uremu HPMC yakawanda hydrophilic pane yakaderera molecular uremu HPMC uye anogona kutora mvura yakawanda.Izvi zvinodaro nekuti yakakwira molecular uremu HPMCs ine cheni dzakareba dzinogona kupinza uye kugadzira network yakakura, ichiwedzera huwandu hwemvura inogona kubatwa.Nekudaro, zvinofanirwa kucherechedzwa kuti yakawandisa molecular uremu HPMC ichakonzera matambudziko akadai seviscosity uye kugadzirisa matambudziko.
imwe nzira
Chimwe chinhu chinokanganisa simba rekuchengetedza mvura reHPMC imhando yekutsiva.HPMC inowanzouya nemhando mbiri: hydroxypropyl-inotsiva uye methoxy-inotsiva.Iyo hydroxypropyl-inotsiva mhando ine yakakwirira yekunyudza mvura kupfuura iyo methoxy-inotsiva mhando.Izvi zvinodaro nekuti iyo hydroxypropyl boka riripo muHPMC molecule is hydrophilic uye inowedzera hukama hweHPMC yemvura.Kusiyana neizvi, iyo methoxy-inotsiva mhando ishoma hydrophilic uye saka ine yakaderera yekuchengeta mvura.Naizvozvo, mamwe marudzi eHPMC anofanirwa kunyatsosarudzwa zvichienderana nezvinodiwa zvechigadzirwa chekupedzisira.
fungisisa
Iko kusungirirwa kweHPMC kunokanganisawo simba rekuchengetedza mvura.Pakudzika kwakadzika, HPMC haigadziri gel-yakafanana chimiro, saka simba rayo rekuchengetedza mvura rakaderera.Sezvo kuwanda kweHPMC kwakawedzera, mamorekuru epolymer akatanga kukochekera, achigadzira gel-sechimiro.Iyi gel network inotora uye inochengeta mvura, uye simba rekuchengetedza mvura reHPMC rinowedzera nekudzikamisa.Nekudaro, zvinofanirwa kucherechedzwa kuti yakanyanya kuwanda kweHPMC inotungamira kumatambudziko ekugadzira senge viscosity uye kugadzirisa matambudziko.Naizvozvo, iko kusungirirwa kweHPMC inoshandiswa kunofanirwa kuvandudzwa kuti iwane yaunoda kuchengetedza mvura uku uchidzivirira matambudziko ataurwa pamusoro.
PH kukosha
Iyo pH kukosha kwenzvimbo iyo HPMC inoshandiswa ichakanganisawo simba rekuchengetedza mvura.Iyo HPMC chimiro chine anionic mapoka (-COO-) uye hydrophilic ethylcellulose mapoka (-OH).Iyo ionization ye-COO- mapoka inotsamira pH, uye ionization yavo degree inowedzera nepH.Naizvozvo, HPMC ine yakakwira yekuchengetera mvura simba pane yakakwirira pH.Pa pH yakaderera, iyo -COO- boka rinoitwa protonated uye hydrophilicity yaro inodzikira, zvichikonzera kuderera kwekuchengetedza mvura.Naizvozvo, iyo pH yezvakatipoteredza inofanirwa kuvandudzwa kuti iwane inodiwa kuchengetedza mvura yeHPMC.
mukupedzisa
Mukupedzisa, simba rekuchengetedza mvura reHPMC chinhu chakakosha chinokanganisa kushanda kwayo semushonga wemishonga.Zvinhu zvakakosha zvinokanganisa kuchengetedza kwemvura kweHPMC zvinosanganisira huremu hwemamorekuru, rudzi rwekutsiva, kutarisisa uye pH kukosha.Nekunyatso gadzirisa zvinhu izvi, simba rekuchengetedza mvura reHPMC rinogona kuvandudzwa kuti rizadzise zvinodiwa zvechigadzirwa chekupedzisira.Pharmaceutical researchers nevagadziri vanofanirwa kutarisisa kune izvi zvinhu kuti ive nechokwadi chemhando yepamusoro uye kushanda kweHPMC-based drug formulations.
Nguva yekutumira: Aug-05-2023