Hydroxypropyl methylcellulose, inowanzozivikanwa se HPMC, inogadzirwa ne cellulose inoshandiswa zvakanyanya mumaindasitiri akasiyana siyana, kusanganisira mishonga, chikafu, zvizorwa, kuvaka, nezvimwe. Chimwe chezvinhu zvinoshamisa zveHPMC kugona kwayo kuchengetedza mvura.HPMC inogona kutora uye kuchengetedza yakawanda yemvura, ichipa yakanakisa kukora, gelling uye kudzikamisa zvivakwa kune zvakawanda zvigadzirwa.Nekudaro, iyo mvura yekuchengetedza simba yeHPMC ine hukama kune akati wandei zvinhu, kusanganisira tembiricha.
Tembiricha ndechimwe chezvinhu zvakakosha zvinokanganisa kuchengetwa kwemvura kweHPMC.Iyo solubility uye viscosity yeHPMC inotsamira tembiricha.Kazhinji, HPMC inonyanya kunyungudika uye viscous pane tembiricha yepamusoro.Sezvo tembiricha ichiwedzera, maketani emolecular eHPMC anowedzera kufamba, uye mamorekuru emvura ane mukana wakakura wekudyidzana nenzvimbo dzehydrophilic dzeHPMC, zvichikonzera kuchengetedza kwemvura.Kusiyana neizvi, pakudzika kwakadzika, maketani emakemikari eHPMC akanyanya kuomarara, uye zvakaoma kuti mamorekuru emvura apinde muHPMC matrix, zvichikonzera kuderera kwemvura.
Tembiricha inokanganisawo kinetics yekupararira kwemvura muHPMCs.Nekuda kwekuwedzera kwemvura yemaketani eHPMC, kunyura kwemvura uye kutora kwemvura kweHPMC kwakakwira pakupisa kwepamusoro.Kune rimwe divi, mwero wekuburitswa kwemvura kubva kuHPMC unokurumidza pakudziya kwepamusoro nekuti tembiricha yepamusoro inowedzera simba rekupisa remamorekuru emvura, zvichiita kuti zvive nyore kwavari kutiza kubva kuHPMC matrix.Naizvozvo, tembiricha ine mhedzisiro yakakosha pane zvese kunyura kwemvura uye kuburitsa zvimiro zveHPMC.
Kuchengetwa kwemvura kweHPMC pane tembiricha dzakasiyana kune akati wandei maitiro.Muindasitiri yemishonga, HPMC inoshandiswa zvakanyanya sebhainda, disintegrant, uye kuburitsa-inodzora mumiriri mukugadzira piritsi.Kuchengetwa kwemvura kweHPMC kwakakosha kuti ive nechokwadi chekuenderana uye kwakaringana kuendesa zvinodhaka.Nekunzwisisa mashandiro etembiricha paHPMC kuchengetedza mvura, vagadziri vanogona kugadzira yakasimba uye inoshanda mahwendefa maumbirwo ayo anogona kumirisana nekusiyana kwekuchengetedza uye kutumira mamiriro.Semuenzaniso, kana piritsi racho rakachengetwa kana kutakurwa pasi pemamiriro ekushisa kwepamusoro, HPMC ine mvura yakakwirira yekuchengetedza inogona kusarudzwa kuderedza kurasikirwa kwemvura, iyo inogona kukanganisa kugadzikana uye kushanda kwehwendefa.
Muindasitiri yechikafu, HPMC inoshandiswa semulsifier, thickener uye stabilizer muzvigadzirwa zvakasiyana-siyana senge sosi, soups uye madhiri.Iyo yekuchengeta mvura zvivakwa zveHPMC zvinogona kukanganisa manyorerwo, viscosity uye kugadzikana kwezvigadzirwa zvekudya.Semuyenzaniso, HPMC ine yakakwirira kuchengetwa kwemvura inogona kupa aizikirimu ine yakatsetseka mameseji uku ichichengetedza kugadzikana kwayo panguva yekuchengetedza uye yekufambisa pane tembiricha dzakasiyana.Saizvozvowo, mukuumbwa kwezvizoro, HPMC inoshandiswa seyakakora, binder uye emulsion stabilizer.Kuchengetwa kwemvura kweHPMC kunogona kukanganisa zvakanyanya kuenderana, kupararira uye hupenyu hwesherufu hwezvigadzirwa zvekuzora.Naizvozvo, vanogadzira vanofanirwa kufunga nezve mhedzisiro yekushisa pane yekuchengeta mvura zvivakwa zveHPMC kuti ive nechokwadi chekuita kwakakwana uye kunaka kwechigadzirwa chekupedzisira.
Kuita kwekuchengetedza mvura kweHPMC kunokanganisa zvakanyanya nekupisa.Iyo solubility, viscosity, kunyura kwemvura uye kuburitsa zvimiro zveHPMC zvese zvinoshandurwa nekushanduka kwetembiricha, zvichikanganisa kuita kweHPMC mumashandisirwo akasiyana.Kunzwisisa tembiricha-inoenderana nekuchengetedza mvura zvivakwa zveHPMC kwakakosha pakugadzira inoshanda uye yakasimba maumbirwo emaindasitiri akasiyana.Naizvozvo, vaongorori nevagadziri vanofanirwa kufunga nezve mhedzisiro yetembiricha pane yekuchengeta mvura zvivakwa zveHPMCs kukwidziridza maapplication avo uye kuwedzera mabasa avo.
Nguva yekutumira: Aug-31-2023