Hydroxypropylmethylcellulose (HPMC) i polymer inoshanda yakawanda inoshandiswa zvakanyanya muindasitiri yemishonga.Iyo ndeyechikamu che cellulose ether uye inotorwa kubva kune yakasikwa cellulose.HPMC inogadzirwa nekurapa cellulose nepropylene oxide uye methyl chloride, zvichikonzera makomisheni ane kunyungudika nekunyungudika nezvimwe zvinodikanwa.Uyu mushonga wemishonga unoshandiswa zvakanyanya mukuvandudza nekugadzira mafomu akasiyana-siyana, kusanganisira mahwendefa, capsules, ophthalmic kugadzirira uye inodzorwa-kuburitsa zvinodhaka masisitimu.
Nhanganyaya yehydroxypropyl methylcellulose:
Kemikari chimiro uye zvivakwa:
Hydroxypropyl methylcellulose is semi-synthetic, inert, mvura-soluble polima.Chimiro chayo chemakemikari chinosanganisira hydroxypropyl uye methoxy mapoka akabatanidzwa kune cellulose musana.Huyero hwezvitsivi izvi hunogona kusiyana, zvichikonzera magiredhi akasiyana eHPMC ane akasiyana zvivakwa.Iyo yekutsiva pateni inokanganisa paramita senge viscosity, solubility, uye gel zvivakwa.
Manufacturing process:
Kugadzirwa kweHPMC kunosanganisira etherification ye cellulose ine propylene oxide uye methyl chloride.Iyo dhigirii yekutsiva (DS) yehydroxypropyl uye methoxy mapoka anogona kudzorwa panguva yekubatanidza, zvichibvumira kugadzirwa kweHPMC zvivakwa kune zvakatemwa zvekugadzira zvinodhaka zvinodiwa.
Zvikumbiro muindasitiri yemishonga:
Binders mukugadzirwa kwehwendefa:
HPMC inoshandiswa zvakanyanya sebhainda mukugadzira piritsi.Kusunga kwayo kunobatsira mukudzvanya hupfu kuita mahwendefa akasimba.Kudzorwa kusunungurwa kweanoshanda mishonga yemishonga (APIs) inogona kuwanikwa kuburikidza nekushandisa chaiwo mamakisi eHPMC ane viscosity yakakodzera uye mazinga ekutsiva.
Film coating agent:
HPMC inoshandiswa semushonga wekuputira firimu wemapiritsi nemagranules.Inopa yunifomu yekudzivirira yekudzivirira iyo inovandudza kutaridzika, kuravira masking uye kugadzikana kweyero mafomu.Uyezve, HPMC-based coatings inogona kuenzanisa maprofile ekuburitsa zvinodhaka.
Kusunungurwa kwakasimba uye kwakadzorwa:
Iyo hydrophilic chimiro chepolymer iyi inoita kuti ive yakakodzera kushandiswa mune inosimudzira- uye inodzorwa-kuburitsa magadzirirwo.Iyo HPMC matrix inobvumira inodzorwa kuburitswa kwezvinodhaka kwenguva yakareba, kuvandudza kutevedza kwevarwere uye kuderedza dosing frequency.
Kugadzirira kweOphthalmic:
Mune ophthalmic formulations, HPMC inoshandiswa kuwedzera viscosity yemadonhwe emeso, nekudaro ichipa nguva yakareba yekugara pane yemeso.Izvi zvinowedzera bioavailability yemushonga uye kurapa kwakanaka.
Kuwedzera stabilizer:
HPMC inoshandiswa seyakakora uye inodzikamisa mumvura uye semi-yakasimba maumbirwo akadai senge gels, makirimu uye kuturika.Inopa viscosity kune aya magadzirirwo uye inovandudza yavo yese rheological properties.
Zvinhu zvakakosha zveHPMC:
Solubility:
HPMC inonyungudika mumvura uye inoita mhinduro yakajeka, isina ruvara.Mwero wekuparara unokanganiswa nehuwandu hwekutsiva uye viscosity giredhi.
Viscosity:
Iyo viscosity yeHPMC mhinduro yakakosha pakuona mashandiro avo mumashandisirwo akasiyana siyana.Magiredhi akasiyana anowanikwa ane maviscosities akasiyana, achibvumira kunyatso kudzora kweiyo rheological maitiro ekuumbwa.
Thermal gelation:
Mamwe mamakisi eHPMC anoratidza thermogelling zvivakwa, achigadzira gels pakupisa kwakanyanya.Ichi chivakwa chinoshandiswa kugadzira zvigadziriso zvinonzwa kupisa.
kugarisana:
HPMC inofambirana neyakasiyana-siyana yemishonga yemishonga uye APIs, zvichiita kuti ive sarudzo yekutanga kune vanogadzira.Haiite pamwe kana kudzikisira zvinhu zvakawanda zvinoshanda.
Matambudziko uye kufunga:
Hygroscopicity:
HPMC is hygroscopic, zvichireva kuti inotora hunyoro kubva kunharaunda.Izvi zvinokanganisa kugadzikana uye kutaridzika kwekuumbwa, saka mamiriro ekuchengetedza akakodzera anodiwa.
Kuenderana nezvimwe excipients:
Kunyangwe kazhinji zvichienderana, vanogadzira vanofanirwa kufunga nezve kuenderana kweHPMC nezvimwe zvinobatsira kudzivirira kusangana kungangokanganisa mashandiro ekugadzira.
Mhedzisiro pa dissolution curve:
Sarudzo yegiredhi reHPMC inogona kukanganisa zvakanyanya kuparara kwemushonga.Mugadziri anofanirwa kunyatsosarudza giredhi rakakodzera kuti awane hunhu hwekuburitsa hunodiwa.
Regulatory kufunga:
HPMC inogamuchirwa zvakanyanya seyakachengetedzeka uye inoshanda yemishonga excipient.Iyo inosangana neyakasiyana-siyana yekutonga zviyero uye inosanganisirwa mune pharmacopoeias kutenderera pasirese.Vagadziri vanofanirwa kutevedzera Yakanaka Kugadzira Maitiro (GMP) kuve nechokwadi chemhando uye kuenderana kwezvigadzirwa zvemishonga zvine HPMC.
mukupedzisa:
Hydroxypropylmethylcellulose (HPMC), sechinhu chinogoneka uye chinoshandiswa zvakanyanya, inoita basa rakakosha muindasitiri yemishonga.Hunhu hwayo hwakasiyana hunoita kuti ive yakakodzera kushandiswa mumhando dzakasiyana dzeyero, kusanganisira mapiritsi, capsules uye ophthalmic kugadzirira.MaFormulators anobatsirwa nekukwanisa kugadzirisa zvimiro zveHPMC kuti isangane nezvinodiwa zvekuumbwa, senge kuburitswa kunodzorwa uye kugadzikana kwakagadziridzwa.Pasinei nezvimwe zvinonetsa, HPMC inoramba iri chinhu chakakosha mukugadzirwa kwezvigadzirwa zvemishonga zvemhando yepamusoro, zvichiita kuti kuchengetedzwa uye kushanda kwemishonga yakawanda.
Nguva yekutumira: Zvita-15-2023