Hydroxypropyl methyl cellulose HPMC isiri-ionic cellulose yakavhenganiswa ether mune zvakasiyana-siyana uye ionic methyl carboxymethyl cellulose yakasanganiswa ether, haina kuita nesimbi inorema.Imwe okisijeni radicals nekuda kweiyo hydroxypropyl methyl cellulose yemukati uye chikamu chakasiyana cheiyo hydroxypropyl yemukati uye viscosity, yakava mhando dzakasiyana pakuita, semuenzaniso, yakakwira methoxyl yemukati uye yakaderera yemhando yehydroxypropyl, kuita kwayo kuri padyo nemethyl cellulose uye yakaderera methoxyl. zvemukati uye zvakakwirira zvemhando dzehydroxypropyl, uye kuita kwayo kuri padyo neiyo hydroxypropyl methyl cellulose inogadzirwa.Asi mune imwe neimwe yakasiyana-siyana, kunyange zvazvo iine zvishoma zvishoma zvehydroxypropyl kana zvishoma zvemethoxy, iyo solubility mu organic solvents kana flocculation tembiricha mune aqueous mhinduro, pane musiyano mukuru.
1, hydroxypropyl methyl cellulose solubility
Hydroxypropyl methyl cellulose mumvura solubility ye hydroxypropyl methyl cellulose ichokwadi rudzi rwepropylene oxide (methyl oxypropyl ring) yakagadziridzwa methyl cellulose, saka ichine zvakafanana nemethyl cellulose mvura inotonhora inonyungudika uye inopisa isinganyunguke hunhu hwemvura.Nekudaro, tembiricha yegelation yemodified hydroxy propyl yakakwira zvakanyanya kupfuura yemethyl cellulose mumvura inopisa.Semuyenzaniso, viscosity yehydroxypropyl methylcellulose aqueous solution ine 2% methoxy content DS=0.73 uye hydroxypropyl content MS=0.46 is 500 mpa at 20℃.Iyo tembiricha yegel yechigadzirwa cheS iri padyo ne100 ℃, nepo iyo yemethyl cellulose yetembiricha imwe chete ingangoita 55 ℃.Kana iri kunyungudika kwayo mumvura, zvakare yakagadziridzwa zvakanyanya, semuenzaniso, mushure mekupwanya kwehydroxypropyl methylcellulose (zviyo chimiro 0.2 ~ 0.5mm pa 20 ℃ 4% aqueous viscosity ye2pA? S zvigadzirwa zvinogona kunyungudika nyore mumvura pasina kutonhora mukamuri tembiricha. .
(2) Hydroxypropyl methyl cellulose mu organic solvents solubility yehydroxypropyl methyl cellulose mune organic solvents solubility, zvakare iri nani pane methyl cellulose, methyl cellulose inoda mune methoxy substitution degree ye2.1 kana zvimwe zvigadzirwa, uye ine hydroxypropyl MS = 1.5 ~ 1.8 uye methoxy uye methoxy DS=0.2 ~ 1.0, High viscosity hydroxypropyl methyl cellulose ine yakazara substitution degree pamusoro pe1.8 inonyungudika muanhydrous methanol uye ethanol mhinduro, uye ine thermoplastic uye mvura solubility.Inonyungudika zvakare mu chlorinated hydrocarbons senge dichloromethane uye trichloromethane, uye organic solvents senge acetone, isopropyl doro, uye diacetone doro.Kunyungudika kwayo mumaorganic solvents kunopfuura kunyungudika kwemvura.
2, hydroxypropyl methyl cellulose viscosity yezvinhu zvinofurira
Hydroxypropyl methylcellulose viscosity factors hydroxypropyl methylcellulose standard viscosity determination, uye imwe cellulose ether yakafanana, iri pa20 ℃ ine 2% aqueous solution seyakajairwa kutsunga.Iyo viscosity yechigadzirwa chimwe chete, nekuwedzera kwekutarisisa uye kuwedzera, iyo yakafanana yekusangana kweakasiyana mamorekuru uremu zvigadzirwa, molecular uremu hwechigadzirwa yakakwirira viscosity.Hukama hwayo nekupisa hwakafanana neyemethyl cellulose.Kana kutonhora kuchikwira, viscosity inotanga kuderera, asi kana yasvika kune imwe tembiricha, viscosity inongoerekana yasimuka uye gelation inoitika.Iyo tembiricha yegelation yezvigadzirwa zvine yakaderera viscosity yakakwira kupfuura yezvigadzirwa zvine high viscosity.Chiyero cheiyo gel point, kuwedzera kune yakakwirira uye yakaderera viscosity ye ether, asiwo ne ether methoxy uye hydroxypropyl boka rekugadzira reshiyo uye iyo yakazara dhigirii yekutsiva yakabatana.Zvinofanira kucherechedzwa kuti hydroxypropyl methylcellulose zvakare pseudoplastic;mhinduro yayo yakagadzikana kana yakachengetwa mukamuri tembiricha uye hairatidze chero kuderedzwa kwe viscosity kunze kwekugona kwe enzymatic degradation.
3, hydroxypropyl methyl cellulose asidhi uye alkaline kuramba
Hydroxypropyl methylcellulose acid alkali hydroxypropyl methylcellulose acid uye alkali, kazhinji yakagadzikana, mu ph PH2 ~ 12 mutsara haina kukanganiswa, inogona kumira imwe huwandu hweasidhi yakaoma, yakadai se formic acid, acetic acid, citric acid, succinic acid, phosphoric. asidhi, boric asidhi, etc. Asi iyo yakanyanyisa asidhi ine mhedzisiro yekuderedza viscosity.Alkali yakadai se caustic soda, caustic potassium uye lime mvura haina mhedzisiro pairi, asi mhedzisiro yekuwedzera zvishoma viscosity yemushonga inoderera zvishoma nezvishoma mune ramangwana.
4, hydroxypropyl methyl cellulose inogona kusanganiswa
Hydroxypropyl methyl cellulose mhinduro inogona kusanganiswa nemvura-inonyungudika polymer komisheni, uye ive yunifomu yakajeka mhinduro ine yakakwira viscosity.Izvi zvakakwirira zvemamolecular compounds polyethylene glycol, polyvinyl acetate, polysilicone, polymethyl vinyl siloxane uye hydroxyethyl cellulose uye methyl cellulose, etc. Natural polymer compounds yakadai segum Arabic, mhashu yebhinzi gum, minzwa yemuti gum uye zvichingodaro zvakare ine musanganiswa wakanaka neayo. mhinduro.Hydroxypropyl methyl cellulose inogonawo kusanganiswa ne stearic acid kana palmitic acid mannitol ester kana sorbitol ester, asiwo ne glycerol, sorbitol uye mannitol, izvi zvinosanganiswa zvinogona kushandiswa se hydroxypropyl methyl cellulose plasticizer.
5, hydroxypropyl methyl cellulose insoluble mvura inonyungudika
Hydroxypropyl methyl cellulose insoluble water-soluble cellulose ether, inogona kuva pamusoro-inosangana nealdehydes, uye ichiita kuti mvura inonyungudika ether inonaya mumushonga, isanyungudika mumvura.Uye kugadzira hydroxypropyl methylcellulose insoluble aldehyde, formaldehyde, glyoxal, succinaldehyde, dialdehyde, nezvimwewo, kushandiswa kwe formaldehyde kunofanirwa kutarisisa kukosha kwePH yemhinduro, umo glyoxal inokurumidza kuita, saka mukugadzirwa kwemaindasitiri kunowanzoshandiswa glyoxal semuchinjikwa. -kubatanidza mumiririri.Muyero werudzi urwu rwe crosslinking agent mumhinduro i 0.2% ~ 10% ye ether mass, yakanakisisa i 7% ~ 10%, sekushandiswa kweglyoxal ne 3.3% ~ 6% ndiyo inonyanya kukodzera.Iyo yakawanda yekurapa tembiricha ndeye 0 ~ 30 ℃, nguva iri 1 ~ 120min.Iyo yekuyambuka-inobatanidza reaction inoda kuitwa pasi pemamiriro e acidic.Kazhinji, inorganic yakasimba asidhi kana organic carboxylic acid inowedzerwa kune mhinduro kugadzirisa iyo PH yemhinduro kusvika 2 ~ 6, zviri nani pakati pe 4 ~ 6, uyezve aldehydes inowedzerwa kune muchinjiko-inobatanidza kuita.Maasidhi anoshandiswa hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, hydroxy acetic acid, succinic acid kana citric acid, pakati peiyo formic acid kana acetic acid ndiyo yakanyanya kunaka, nepo formic asidhi ndiyo yakanyanya kunaka.Acids uye aldehydes zvinogonawo kuwedzerwa panguva imwe chete kubvumira mhinduro kuti ienderane-yakabatanidzwa muhuwandu hunodiwa hwePH.Izvi zvinowanzo shandiswa mukugadzirisa kwekupedzisira kwe cellulose ether kugadzirira, kuitira kuti cellulose ether irege kuparara, nyore kushandisa 20 ~ 25 ℃ mvura kushambidza uye kuchenesa.Kana chigadzirwa chikashandiswa, alkaline zvinhu zvinogona kuwedzerwa kune mhinduro yechigadzirwa kugadzirisa PH yemhinduro kuti ive alkaline, uye chigadzirwa chinokurumidza kunyungudutswa mumhinduro.Iyi nzira inogonawo kushandiswa kana cellulose ether mhinduro inoshandiswa kugadzira firimu uye ipapo firimu rinorapwa kuti riite firimu risinganyunguriki.
6, hydroxypropyl methyl cellulose anti-enzyme
Hydroxypropyl methyl cellulose enzyme kuramba kwe cellulose derivatives mune dzidziso, senge yega yega anhydroglucose mapoka senge pane yakasimba musanganiswa wekutsiva mapoka, kukukurwa kwema microorganisms haanyanyi kutapukirwa nehutachiona, asi chokwadi chigadzirwa chakapedzwa kutsiva kukosha kupfuura 1, uyewo nekuparara kwe enzyme, iyi ndiyo tsanangudzo yeboka rimwe nerimwe mu cellulose chain substitution degree haisi yunifomu, Microorganisms inogona kuparara pedyo nemapoka asina kuchinjwa eglucose akasvibiswa kuti aumbe shuga, iyo inogona kutorwa nema microorganisms sezvokudya.Naizvozvo, kana iyo etherification inotsiva dhigirii ye cellulose ikawedzera, kurwisa kwe cellulose ether kukukurwa kweenzymatic kuchawedzerwa.Zvinonzi pasi pemamiriro ezvinhu akadzorwa, iyo yakasara viscosity yehydroxypropyl methyl cellulose (DS = 1.9), methyl cellulose (DS = 1.83), methyl cellulose (DS = 1.66), uye hydroxyethyl cellulose (1.7%) yaiva 13.2%, 7.3%. , 3.8%, uye 1.7%, maererano.Hydroxypropyl methyl cellulose ine simba rekurwisa enzyme.Saka hydroxypropyl methylcellulose yakanakisa anti-enzyme, yakasanganiswa nekupararira kwayo kwakanaka, kukora uye kuumbwa kwemafirimu, inoshandiswa mu emulsion coatings, nezvimwewo, kazhinji haidi kuwedzera zvinodzivirira.Zvisinei, kuitira kudzivirira kuchengetwa kwenguva refu kwekugadzirisa kana kusvibiswa kunogona kuitika kubva kunze kwenyika, zvidziviriro zvinogona kuwedzerwa, izvo zvakasarudzwa zvinogona kugadziriswa maererano nezvinodiwa zvekupedzisira zvekugadzirisa.Phenylmercuric acetate uye manganese fluosilicate zvinochengetedza zvinobudirira, asi zvine muchetura uye zvinofanirwa kunyatsoshandiswa.Kazhinji, 1 ~ 5mg phenylmercuric acetate inogona kuwedzerwa kune rimwe nerimwe remhinduro.
7, hydroxypropyl methyl cellulose membrane kuita
Hydroxypropyl methyl cellulose film performance yehydroxypropyl methyl cellulose ine firimu rakanakisa, mhinduro yaro yemvura kana organic solvent solution, yakavharwa pandiro yegirazi, mushure mekuoma inova isina ruvara, yakajeka uye yakaoma firimu.Iine hunyoro hwakanaka hwekudzivisa uye inoramba yakasimba pakupisa kwepamusoro.Zvakadai sekuwedzera kwe hygroscopic plasticizer, inogona kukwidziridza kureba kwayo uye kuchinjika, kuvandudza flexure, glycerol uye sorbitol uye imwe plasticizer ndiyo inonyanya kukodzera.Iyo general solution yekumisikidza ndeye 2% ~ 3%, iyo plasticizer dosage i10% ~ 20% ye cellulose ether.Kana zvirimo zveplasticizer zviripo, iyo shrinkage phenomenon ye colloid dehydration inogona kuitika mukunyorova kwakanyanya.Kusimba kwekusimba kwefirimu yakawedzerwa plasticizer yakakura zvikuru kupfuura iyo isina kuwedzerwa, uye inowedzera nekuwedzera kwehuwandu hwekuwedzera, sezvo ye hygroscopicity yefirimu inowedzerawo nekuwedzera kwehuwandu hweplasticizer.
Nguva yekutumira: Sep-08-2022