Hydroxypropyl methylcellulose (HPMC) ipolymer inoshandiswa zvakasiyana-siyana ine zvakasiyana-siyana zvekushandisa mumaindasitiri akasiyana anosanganisira mishonga, chikafu, kuvaka uye zvizorwa.Iyo mikuru yemidziyo inoshandiswa kugadzira HPMC i cellulose uye propylene oxide.
1. Cellulose: hwaro hweHPMC
1.1 Pfupiso ye cellulose
Cellulose ndiyo yakaoma carbohydrate inova chikamu chikuru chezvakasvibirira masero emadziro.Iyo ine mutsara cheni dzeglucose mamorekuru akabatanidzwa pamwechete ne β-1,4-glycosidic bond.Kuwanda kwemapoka e-hydroxyl mu cellulose inoita kuti ive yakakodzera kutanga zvinhu zvekubatanidza zvakasiyana-siyana zvema cellulose zvinobva, kusanganisira HPMC.
1.2 Kutenga cellulose
Cellulose inogona kutorwa kubva kune zvakasiyana zvirimwa zvemiti, senge pulp yehuni, machira ekotoni, kana zvimwe zvinomera zvine fibrous.Huni pulp inzvimbo yakajairika nekuda kwekuwanda kwayo, kudhura-kushanda, uye kusimba.Kubviswa kwe cellulose kunowanzo sanganisira kuputsa tambo dzezvirimwa kuburikidza nenhevedzano yemechanical uye kemikari maitiro.
1.3 Kuchena uye maitiro
Hunhu uye kuchena kwe cellulose kwakakosha pakuona hunhu hweHPMC yekupedzisira chigadzirwa.Yakakwirira-kuchena cellulose inova nechokwadi chekuti HPMC inogadzirwa ine inowirirana zvivakwa senge viscosity, solubility uye kugadzikana kwekupisa.
2. Propylene oxide: kuiswa kweboka re hydroxypropyl
2.1 Nhanganyaya yepropylene oxide
Propylene oxide (PO) musanganiswa une makemikari formula C3H6O.Iyo epoxide, zvichireva kuti ine atomu yeokisijeni yakasungirirwa kune maviri ari padyo neatomu kabhoni.Propylene oxide ndiyo kiyi mbishi zvinhu zvekugadzirwa kwehydroxypropyl cellulose, inova yepakati pakugadzirwa kweHPMC.
2.2 Hydroxypropylation maitiro
Iyo hydroxypropylation process inosanganisira kuita kwe cellulose nepropylene oxide kuunza mapoka ehydroxypropyl pamusana we cellulose.Kuita uku kunowanzoitwa pamberi pechinhu chinokonzeresa.Mapoka eHydroxypropyl anopa yakagadziridzwa solubility uye zvimwe zvinodikanwa zvivakwa kune cellulose, zvichitungamira mukuumbwa kwehydroxypropyl cellulose.
3. Methylation: Kuwedzera methyl mapoka
3.1 methylation maitiro
Mushure mehydroxypropylation, nhanho inotevera muHPMC synthesis ndeye methylation.Maitiro acho anosanganisira kuunzwa kwemapoka emethyl pane cellulose musana.Methyl chloride inowanzoshandiswa reagent kune iyi maitiro.Iyo dhigirii yemethylation inokanganisa zvimiro zvekupedzisira HPMC chigadzirwa, kusanganisira viscosity yayo uye gel maitiro.
3.2 Dhigirii yekutsiva
Iyo dhigirii yekutsiva (DS) ndiyo yakakosha parameter yekuenzanisa nhamba yeavhareji yezvinotsiva (methyl uye hydroxypropyl) pane anhydroglucose unit mucheni ye cellulose.Maitiro ekugadzira anodzorwa nekuchenjera kuti awane kuita kwaunoda kweHPMC zvigadzirwa.
4. Kucheneswa uye Kudzora Kwehutano
4.1 Kubviswa kwezvakagadzirwa
Iyo synthesis yeHPMC inogona kukonzera kuumbwa kwezvigadzirwa zvakaita semunyu kana mareagents asina kubatwa.Matanho ekuchenesa anosanganisira kugeza uye kusefa anoshandiswa kubvisa tsvina iyi uye kuwedzera kuchena kwechigadzirwa chekupedzisira.
4.2 Matanho ekudzora kunaka
Yakasimba mhando yekudzora matanho anoitwa mukati mekugadzira maitiro kuti ave nechokwadi chekuenderana uye mhando yeHPMC.Maitiro ekuongorora akadai se spectroscopy, chromatography uye rheology anoshandiswa kuongorora paramita senge molecular uremu, dhigirii rekutsiva uye viscosity.
5. Hunhu hweHydroxypropyl Methylcellulose (HPMC)
5.1 Zvimiro zvemuviri
HPMC ihupfu huchena kusvika kuchena, husina hwema hune hunyoro hwekugadzira firimu.Iyo hygroscopic uye inoumba nyore gel yakajeka kana yakapararira mumvura.Kunyungudika kweHPMC kunoenderana nehuwandu hwekutsiva uye kukanganiswa nezvinhu zvakaita setembiricha uye pH.
5.2 Chimiro chemakemikari
Iyo kemikari chimiro cheHPMC ine cellulose musana ine hydroxypropyl uye methyl substituents.Chiyero chezvitsivi izvi, chinoratidzwa muchiyero chekutsiva, chinotarisa chimiro chemakemikari ese uye nekudaro zvimiro zveHPMC.
5.3 Viscosity uye rheological properties
HPMC inowanikwa mumagiredhi akasiyana ane akasiyana viscosity renji.Iyo viscosity yeHPMC mhinduro chinhu chakakosha mumashandisirwo akadai semishonga, uko inokanganisa kuburitswa kwemushonga, uye mukuvaka, uko kunokanganisa kushanda kwemateki nemapaste.
5.4 Kugadzira firimu uye kukora zvivakwa
HPMC inoshandiswa zvakanyanya seyaimbova firimu mumachira emishonga uye seyakakora mumiriri mumhando dzakasiyana dzemagadzirirwo.Hunyanzvi hwayo hwekugadzira firimu hunoita kuti ive yakakosha mukugadzirwa kweanodzorwa-kuburitsa madhiragi ekuputira masisitimu, nepo kukora kwayo kunowedzera kuumbwa nekugadzikana kwezvigadzirwa zvakawanda.
6. Kushandiswa kwehydroxypropyl methylcellulose
6.1 Indasitiri yemishonga
Muindasitiri yemishonga, HPMC inoshandiswa kugadzira oral solid dosage mafomu akadai semapiritsi nemakapisi.Inowanzoshandiswa sebhainda, disintegrant uye firimu coating agent.Izvo zvinodzorwa-kuburitswa zvivakwa zveHPMC zvinofambisa kushandiswa kwayo mukuenderera-kuburitswa mafomati.
6.2 Indasitiri yekuvaka
Muchikamu chekuvaka, HPMC inoshandiswa sechinhu chinochengetedza mvura, chikobvu uye chinonamira muzvigadzirwa zvine simende.Inokwidziridza kushanda kwedhaka, inodzivirira kudonha mumashandisirwo akatwasuka, uye inonatsiridza kuita kwese kwechinhu chekuvaka.
6.3 Indasitiri yezvokudya
HPMC inoshandiswa muindasitiri yechikafu seyakakora, stabilizer uye emulsifier.Kugona kwayo kugadzira gels pakadzika kudzika kunoita kuti ive yakakodzera kune akasiyana maapplication, anosanganisira sosi, madhirezi uye madhiri.
6.4 Zvizoro uye zvigadzirwa zvekuchengeta wega
Muzvizora uye zvigadzirwa zvekuchengeta munhu, HPMC inowanikwa mune dzakasiyana siyana magadzirirwo anosanganisira makirimu, lotions uye shampoos.Inobatsira kuvandudza maitiro, kugadzikana uye kushanda kwese kwezvigadzirwa izvi.
6.5 Mamwe maindasitiri
HPMC's versatility inosvika kune mamwe maindasitiri, anosanganisira machira, pendi uye anonamira, kwaanogona kushandiswa seye rheology modifier, mvura yekuchengetedza mvura uye thickener.
7. Mhedziso
Hydroxypropylmethylcellulose i polymer inoshanda zvakasiyana-siyana ine akawanda maapplication.Kuumbwa kwayo kunoshandisa cellulose uye propylene oxide sechinhu chikuru chemidziyo, uye cellulose inogadziriswa kuburikidza nehydroxypropylation uye methylation maitiro.Kudzora kutonga kwezvinhu izvi mbishi uye maitiro ekuita zvinogona kuburitsa HPMC ine yakagadziridzwa zvivakwa kuti isangane nezvakada indasitiri zvinodiwa.Naizvozvo, HPMC inoita basa rakakosha mukuvandudza mashandiro uye mashandiro ezvigadzirwa mumaindasitiri ese.Kuenderera mberi kwekuongorora kwezvishandiso zvitsva uye kuvandudzwa kwemaitiro ekugadzira kunobatsira HPMC kuramba ichiita basa rakakosha mumusika wepasi rose.
Nguva yekutumira: Zvita-28-2023