Firimu yekuputira idanho rakakosha mukugadzira mishonga, umo mutete wepolymer unoiswa pamusoro pemapiritsi kana macapsules.Uku kupfekedza kunoshanda zvinangwa zvakasiyana, zvinosanganisira kuvandudza chitarisiko, kuravira masking, kuchengetedza inoshanda yemishonga yemishonga (API), kudzora kuburitswa, uye kufambisa kumedza.Hydroxypropyl Methylcellulose (HPMC) ndeimwe yemapolima anonyanya kushandiswa mukuputira firimu nekuda kwemaitiro ayo akasiyana.
1.Zvinhu zveHPMC:
Hydroxypropyl Methylcellulose (HPMC) inonzi semi-synthetic polymer inotorwa kubva muselulosi.Iyo inoratidzirwa nekunyungudika kwayo kwemvura, kugona kugadzira firimu, uye kuenderana kwakanakisa neakasiyana emishonga zvigadzirwa.Izvo zvimiro zveHPMC zvinogona kugadziridzwa nekugadzirisa maparamendi akadai semamorekuru uremu, dhigirii rekutsiva, uye viscosity.
Firimu Kugadzira Kugona: HPMC ine yakanakisa firimu-yekugadzira zvimiro, inogonesa kuumbwa kweyunifomu uye yakatsetseka yakapfava pamusoro peiyo mishonga dosage mafomu.
Kunyungudika kweMvura: HPMC inoratidzira kunyungudika kwemvura, ichibvumira kunyungudika kwepolymer mumhinduro dzine aqueous panguva yekuputira.Ichi chivakwa chinovimbisa kugoverwa kwakafanana kwepolymer uye inofambisa kuumbwa kwehomogeneous coating layer.
Adhesion: HPMC inoratidza kunamatira kwakanaka kumusoro kwemapiritsi kana capsules, zvichikonzera machira akasimba anonamira zvakanaka kune substrate.
Zvipingamupinyi Zvivakwa: HPMC inopa chipingamupinyi kurwisa zvakatipoteredza zvinhu zvakaita sehunyoro, okisijeni, uye mwenje, nekudaro ichidzivirira kutendeseka kwefomu redosi uye kuwedzera kugadzikana.
2.Kufunga nezveKugadzira:
Mukugadzira mhinduro yefirimu-yekuputira uchishandisa HPMC, zvinhu zvakati wandei zvinofanirwa kutariswa kuti zvizadzise zvinodiwa zvekupfeka maitiro uye kuita.
Polymer Concentration: Iyo yekumisikidzwa kweHPMC mune yekubikira mhinduro inokanganisa ukobvu uye mechaniki zvimiro zvefirimu.Yakakwira polymer yakatarisana inokonzeresa machira akakora ane anowedzeredzwa zvipingamupinyi zvivakwa.
Plasticizers: Kuwedzerwa kweplasticizers yakadai se polyethylene glycol (PEG) kana propylene glycol (PG) inogona kuvandudza kushanduka uye elasticity yekuputira, zvichiita kuti irege kupera uye inopesana nekuputika.
Solvents: Kusarudzwa kweakakodzera zvinonyungudutsa kwakakosha kuti ive nechokwadi chekunyungudika kweHPMC uye kuumbwa kwakakodzera kwemafirimu.Kazhinji zvinonyungudutsa zvinosanganisira mvura, ethanol, isopropanol, uye musanganiswa wayo.
Pigments uye Opacifiers: Kuiswa kwe pigment uye opacifiers mu coating kugadzirwa kunogona kupa ruvara, kunatsiridza chitarisiko, uye kupa mwenje dziviriro kumishonga inonzwisisika.
3. Zvishandiso zveHPMC muFirimu Coating:
HPMC-based coatings inowana mashandisirwo akawandisa mumaindasitiri emishonga uye nutraceutical nekuda kwekuita kwavo kwakasiyana-siyana uye kukodzera kwemafomu akasiyana-siyana.
Pakarepo Release Coatings: HPMC machira anogona kushandiswa kupa kukurumidza kuburitswa kwemishonga nekudzora kuparara uye kuparara kwemazinga emapiritsi kana capsules.
Yakagadziridzwa Release Coatings: HPMC-yakavakirwa maumbirwo anowanzo shandiswa muakagadziridzwa kuburitsa dosage mafomu, kusanganisira yakawedzera-kuburitswa uye enteric-yakavharidzirwa maumbirwo.Nekugadzirisa viscosity uye ukobvu hwejasi, iyo yekuburitsa chimiro chemushonga inogona kugadzirwa kuti iwane kuburitswa kwakasimba kana kwakanangwa.
Ravira Masking: HPMC machira anogona kuvhara kuravira kusingafadzi kwemishonga, kuvandudza kutevedza kwemurwere uye kugamuchirwa kwemafomu emumuromo.
Kudzivirirwa Kwemvura: HPMC machira anopa hunyoro kudzivirira hunyoro, kunyanya kune hygroscopic mishonga inokonzeresa kana yasangana nehunyoro.
Kuwedzera Kugadzikana: HPMC machira anopa chipingamupinyi chekudzivirira kubva kune zvakatipoteredza zvinhu, nekudaro kuwedzera kugadzikana uye pasherufu-hupenyu hwezvigadzirwa zvemishonga.
Hydroxypropyl Methylcellulose (HPMC) inoita basa rakakosha mumafirimu ekuputira maapplication muindasitiri yemishonga.Hunhu hwayo hwakasiyana, hunosanganisira kugona kugadzira firimu, kunyungudika kwemvura, kunamatira, uye zvipingamupinyi zvivakwa, zvinoita kuti ive sarudzo yakanaka yekugadzira machira ane akasiyana mashandiro.Nekunzwisisa magadzirirwo ekufunga uye mashandisirwo eHPMC mukuputira firimu, vagadziri vemishonga vanogona kugadzira mafomu emushonga nekuwedzera kuita, kugadzikana, uye kugamuchirwa kwemurwere.
Nguva yekutumira: Mar-07-2024